Children with specific language impairment are more likely to reach motor milestones late

Diepeveen, F.B.; Dommelen, Paula van; Oudesluys‐Murphy, Anne Marie; Verkerk, P.H.

doi:10.1111/cch.12614

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…we observed that children with the developmental disorders have de cits in all domains assessed by the GDDS compared to normally developing children (indicated by high ratings of inadequate development as shown in Table 3). This observation is in accordance with the literature in which developmental disabilities, which are mainly manifested by cognitive, social, gross motor, and ne motor skills are reported for children with DLD [35,36,37] and ASD [38,39,40,41]. Moreover, we observed a negative low-to-moderate correlation between all domains of the GDDS (i.e., adaptive behavior, gross motor skills, ne motor skills, language abilities, and personal-social behavior) and severity of the autism spectrum disorder (operationalized by CARS score) in children with ASD implying a type of "doseresponse" relationship between disease severity and de cits in functional abilities.…”

Section: Discussionsupporting

confidence: 93%

Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China

Liu

Zou

Chen

et al. 2023

Preprint

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In children, both autism spectrum disorder (ASD) and developmental language disorder (DLD) are characterized by serious deficits in language development and have a certain overlap in their symptoms, it is often difficult to reach a clear diagnosis. In this study 3219 children with ASD and DLD were evaluated using the Gesell Developmental Diagnostic Scale (GDDS) and the Childhood Autism Rating Scale (CARS). We observed Children with ASD exhibited a lower score in five domains. And the CARS score shows negative low to moderate correlation with the five domains of the GDDS. Based on our findings, we deduce that GDDS combined with CARS assessment can be helpful for early screening and differential diagnosis of children with ASD and DLD.

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Section: Discussionsupporting

confidence: 93%

Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China

Liu

Zou

Chen

et al. 2023

Preprint

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“…62,63 Children with DLD systematically showed weaker performance on tests of gross and fine motor skills compared with their peers, 64 were impaired at tasks that required for them to synchronize tapping to a beat 65 ; and showed delayed motor development. 66 These observations were consistent with findings that developmental coordination disorder, which affects fine motor skills, was often comorbid with DLD. 5,[67][68][69] The other 2 sets of comorbidities that were associated with DLD were atopic disorders and sleep disorders.…”

Section: Discussionsupporting

confidence: 89%

Association of Developmental Language Disorder With Comorbid Developmental Conditions Using Algorithmic Phenotyping

et al. 2022

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ImportanceDevelopmental language disorder (DLD) is a common (with up to 7% prevalence) yet underdiagnosed childhood disorder whose underlying biological profile and comorbidities are not fully understood, especially at the population level.ObjectiveTo identify clinically relevant conditions that co-occur with DLD at the population level.Design, Setting, and ParticipantsThis case-control study used an electronic health record (EHR)–based population-level approach to compare the prevalence of comorbid health phenotypes between DLD cases and matched controls. These cases were identified using the Automated Phenotyping Tool for Identifying Developmental Language Disorder algorithm of the Vanderbilt University Medical Center EHR, and a phenome enrichment analysis was used to identify comorbidities. An independent sample was selected from the Geisinger Health System EHR to test the replication of the phenome enrichment using the same phenotyping and analysis pipeline. Data from the Vanderbilt EHR were accessed between March 2019 and October 2020, while data from the Geisinger EHR were accessed between January and March 2022.Main Outcomes and MeasuresCommon and rare comorbidities of DLD at the population level were identified using EHRs and a phecode-based enrichment analysis.ResultsComorbidity analysis was conducted for 5273 DLD cases (mean [SD] age, 16.8 [7.2] years; 3748 males [71.1%]) and 26 353 matched controls (mean [SD] age, 14.6 [5.5] years; 18 729 males [71.1%]). Relevant phenotypes associated with DLD were found, including learning disorder, delayed milestones, disorders of the acoustic nerve, conduct disorders, attention-deficit/hyperactivity disorder, lack of coordination, and other motor deficits. Several other health phenotypes not previously associated with DLD were identified, such as dermatitis, conjunctivitis, and weight and nutrition, representing a new window into the clinical complexity of DLD.Conclusions and RelevanceThis study found both rare and common comorbidities of DLD. Comorbidity profiles may be leveraged to identify risk of additional health challenges, beyond language impairment, among children with DLD.

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“…Furthermore, factors such as motor functioning or sensory processing may play a role in explaining the observed variation in the domain of repetitive and restricted behaviors ( Berry et al, 2018 ). Impairments in these domains have been reported in children with DLD ( Diepeveen et al, 2017 ) and in children with 22q11DS ( Van Aken et al, 2009 ). Future studies would need to shed light to what extent the influence of such factors is on the development of ASD-related behaviors, in these groups of children.…”

Section: Strengths Limitations and Future Directionsmentioning

confidence: 99%

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Selten

Boerma

Everaert

et al. 2023

Autism & Developmental Language Impairments

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Background and Aim. Children with Developmental Language Disorder (DLD) are at an increased risk to develop behaviors associated with Autism Spectrum Disorder (ASD). The relationship between early language difficulties and the occurrence of ASD-related behaviors in DLD is poorly understood. One factor that may hinder progress in understanding this relationship is the etiological heterogeneity of DLD. We therefore study this relationship in an etiologically homogeneous group of children, who share phenotypic characteristics with children with DLD: children with the 22q11.2 Deletion Syndrome (22q11DS). We compare children with 22q11DS, to children with DLD and age-matched typically developing children (TD). Method 44 children with 22q11DS, 65 children with DLD and 81 TD children, between 3.0–6.5 years old, participated in a longitudinal cohort study that included a baseline measure and a follow-up measure with a 1-year interval. A parental questionnaire (SRS-2) was used to measure the incidence of behaviors in two key behavioral domains associated with ASD: Social Communication and Interaction and Restricted Repetitive Behaviors and Interests. At baseline, we assessed children's expressive and receptive language abilities as well as their intellectual functioning with standardized tests. We compared the distribution of ASD-related behaviors between the three groups. We used regression analyses to investigate whether language abilities at baseline predict ASD-related behavior at follow-up, accounting for ASD-related behavior at baseline, demographic variables and intellectual functioning. Results Both the children with 22q11DS and the children with DLD displayed significantly more ASD-related behaviors than the TD children. Over 30% of children in both clinical groups had scores exceeding the subclinical threshold for ASD in both behavioral domains. Both in 22q11DS and DLD, baseline receptive language scores were negatively correlated with ASD-related behaviors 1 year later, when controlling for baseline SRS-scores. However, this association was statistically significant only in children with 22q11DS, even when controlled for IQ-scores, and it was significantly stronger as than in the TD group. The strength of the association did not differ significantly between 22q11DS and DLD. Conclusion Both children with 22q11DS and children with DLD present with elevated rates of ASD-related behaviors at a preschool-age. Only in children with 22q11DS we observed that weaker receptive language skills were related to increased behavioral problems in the domain of social communication and interaction one year later. Implications Our findings indicate that relations between early language impairment and other behavioral phenotypes may be more feasible to detect in a subgroup of children with a homogeneous etiology, than in a group of children with a heterogeneous etiology (such as children with DLD). Our results in 22q11DS reveal that receptive language is especially important in predicting the occurrence of ASD-related behaviors. Future research is needed to determine to what extent receptive language predicts the occurrence of ASD-related behaviors in children with DLD, especially among those children with DLD with the weakest receptive language. Clinically, screening for ASD-related behaviors in children with developmental language difficulties is recommended from a young age, especially among children with receptive language difficulties.

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Children with specific language impairment are more likely to reach motor milestones late

Cited by 14 publications

References 22 publications

Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China

Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China

Association of Developmental Language Disorder With Comorbid Developmental Conditions Using Algorithmic Phenotyping

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

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