“…Some critical signaling pathways, including the wingless-related integration site (WNT), ectodysplasin A receptor (EDAR), and bone morphogenetic proteins (BMP) pathways, are regarded as regulatory hubs during fiber development (Lu et al, 2016;Telerman et al, 2017). Mammals, and in particular, sheep and goats have obvious periodic fiber growth with seasonal changes, and the regulatory mechanisms of these changes have been explored in transcriptome studies (Yang et al, 2017;Li et al, 2018). Subsequently, some genetic factors, such as those of the TCHH, KRT gene families, and the metallothionein 3 isoforms, which are related to curly wool, h a v e b e e n d e t e r m i n e d b y R N A -s e q a n a l y s i s a n d immunohistochemical analyses of the fiber proteins (Sriwiriyanont et al, 2011;Yu et al, 2011;Kang et al, 2013).…”