Anterior and Intermediate Uveitis Following Yellow Fever Vaccination with Fractional Dose: Case Reports

Biancardi, Ana Luiza; Moraes, Haroldo Vieira de

doi:10.1080/09273948.2018.1510529

Cited by 32 publications

(28 citation statements)

References 8 publications

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“…We also agree with other authors [10] that it’s not possible to establish direct causal correlation between vaccination and uveitis, only presumable. But the increasing amount of reports with similar temporal correlations should draw our attention to a new spectrum of adverse reactions, especially in association to isolated YF vaccines.…”

Section: Discussionsupporting

confidence: 92%

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Diffuse uveitis and chorioretinal changes after yellow fever vaccination: a re-emerging epidemic

et al. 2019

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BackgroundWith increasing incidence of yellow fever, mass campaign vaccinations are underway and little ophthalmological alterations have been reported in literature, specially regarding non-combined vaccines.Case presentationWe report the case of a patient with no previous ocular or systemic diseases whom received a single dose of yellow fever vaccination and developed haematological, hepatic and renal alterations progressing with a later onset bilateral asymmetric diffuse uveitis. Ophthalmological findings included fine keratic precipitates scattered throughout the cornea and mild vitritis. Multimodal evaluation showed subtle puntiform choriocapillaris changes with decreased vascular density associated. The patient had a good visual outcome after mild oral prednisone dose, but the image findings have not presented remission.ConclusionsClinicians should be aware of clinical and subclinical ocular manifestations such as subtle puntiform choriocapillaris changes as possible vaccine-related adverse events with potential to impact vision.

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Section: Discussionsupporting

confidence: 92%

“…Likewise our patient, Biancardi and Moraes [10] reported ocular inflammation cases after YF fractional dose vaccination but presenting as anterior or intermediate uveitis. Stangos et al [11] as well as Escott et al reported cases of posterior uveitis but secondary to combined vaccination for yellow fever and hepatitis A.…”

Section: Discussionsupporting

confidence: 72%

Diffuse uveitis and chorioretinal changes after yellow fever vaccination: a re-emerging epidemic

et al. 2019

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“…Acute anterior and intermediate uveitis presented by our patient 2 to 3 weeks after YFV vaccination could be related to the vaccine. Yellow fever vaccination is known to be associated with uveitis and other ophthalmologic manifestations such as vasculopathy and optic neuritis, even if the frequency of these manifestations is unknown [17]. The cerebro-spinal liquid analysis was not performed in our case.…”

Section: Discussionmentioning

confidence: 88%

Viscerotropic disease and acute uveitis following yellow fever vaccination: a case report

et al. 2020

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Background: Yellow fever vaccine exists for over 80 years and is considered to be relatively safe. However, in rare cases it can produce serious neurotropic and viscerotropic complications. We report a case of a patient who presented both viscerotropic and neurological manifestations after yellow fever vaccination. Case presentation: We describe the case of a 37 years old man who developed after the yellow fever vaccination a yellow fever vaccine-associated viscerotropic disease followed by acute uveitis. Prolonged detection of yellow fever RNA in blood and urine was consistent with yellow fever vaccine-associated adverse event. The final outcome was good, although with persistent fatigue over a few months. Conclusions: Even if the yellow fever vaccine is relatively safe, physicians should be aware of its possible serious adverse effects.

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“…There also exist case reports of ocular disorders associated with YFV vaccination, especially when the live YFV vaccine is combined with other vaccines, such as Neisseria Meningitidis, Hepatitis A/B or Typhoid. The reported complications are varied and include uveitis, unilateral optic neuropathy, evanescent white dot syndrome, multifocal choroiditis, arteriolar occlusion and even a Vogt-Koyanagi-Harada-like disease (with accompanying serous retinal detachment and choroidal thickening) [109,168,169]. These conditions are rarely reported and most often self-limiting with a favourable course over a few weeks with simple supportive anti-inflammatory treatment.…”

Section: Yellow Fever Virus (Flaviviridae)mentioning

confidence: 99%

Ocular manifestations of emerging viral diseases

Venkatesh

Patel

Goyal

et al. 2021

Eye

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Emerging infectious diseases (EIDs) are an increasing threat to public health on a global scale. In recent times, the most prominent outbreaks have constituted RNA viruses, spreading via droplets (COVID-19 and Influenza A H1N1), directly between humans (Ebola and Marburg), via arthropod vectors (Dengue, Zika, West Nile, Chikungunya, Crimean Congo) and zoonotically (Lassa fever, Nipah, Rift Valley fever, Hantaviruses). However, specific approved antiviral therapies and vaccine availability are scarce, and public health measures remain critical. Patients can present with a spectrum of ocular manifestations. Emerging infectious diseases should therefore be considered in the differential diagnosis of ocular inflammatory conditions in patients inhabiting or returning from endemic territories, and more general vigilance is advisable in the context of a global pandemic. Eye specialists are in a position to facilitate swift diagnosis, improve clinical outcomes, and contribute to wider public health efforts during outbreaks. This article reviews those emerging viral diseases associated with reports of ocular manifestations and summarizes details pertinent to practicing eye specialists.

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Anterior and Intermediate Uveitis Following Yellow Fever Vaccination with Fractional Dose: Case Reports

Abstract: Physicians should be aware of the possibility of eye inflammation following the yellow fever vaccination.

Cited by 32 publications

References 8 publications

Diffuse uveitis and chorioretinal changes after yellow fever vaccination: a re-emerging epidemic

Diffuse uveitis and chorioretinal changes after yellow fever vaccination: a re-emerging epidemic

Viscerotropic disease and acute uveitis following yellow fever vaccination: a case report

Ocular manifestations of emerging viral diseases

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