CCN3 secreted by prostaglandin E2 inhibits intimal cushion formation in the rat ductus arteriosus

Iwai, Kenji; Nagasawa, Kazuya; Akaike, Toru; Oshima, T; Kato, Takashi; Minamisawa, Susumu

doi:10.1016/j.bbrc.2018.08.138

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…PGE 2 has also been shown to increase cellular communication network factor 3 (CCN3) mRNA and protein expression in the rat DA, leading to decreased intimal cushion formation. The intimal cushion is a smooth muscle layer that helps to close the DA, and these results further demonstrate the importance of prostaglandin signaling in controlling proper DA patency during development [ 256 ]. These effects are not just limited to one particular vessel.…”

Section: Recent Advances In Bioactive Lipids In Cardiac Developmenmentioning

confidence: 90%

Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

Wasserman

Venkatesan

Aguirre

2020

Cells

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Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic strategies aimed at restoring cardiovascular function. Bioactive lipids are a class of dietary-dependent, chemically heterogeneous lipids with potent biological signaling functions. They have been intensively studied for their roles in immunity, inflammation, and reproduction, among others. Recent advances in liquid chromatography-mass spectrometry techniques have revealed a staggering number of novel bioactive lipids, most of them unknown or very poorly characterized in a biological context. Some of these new bioactive lipids play important roles in cardiovascular biology, including development, inflammation, regeneration, stem cell differentiation, and regulation of cell proliferation. Identifying the lipid signaling pathways underlying these effects and uncovering their novel biological functions could pave the way for new therapeutic strategies aimed at CVD and cardiovascular regeneration.

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Section: Recent Advances In Bioactive Lipids In Cardiac Developmenmentioning

confidence: 90%

Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

Wasserman

Venkatesan

Aguirre

2020

Cells

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Patent Ductus Arteriosus in the Preterm Infant

CLYMAN¹

2024

Avery's Diseases of the Newborn

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Clinical and morphological features of arterial duct in premature newborns

Saryeva¹,

Харламова

Kulida

et al. 2022

Ross. vestn. perinatol. pediatr.

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The open arterial duct has a pathological significance in premature newborns. Closure of the ductus arteriosus is a complex process that includes functional and anatomical closure.Purpose. To identify the features of arterial duct remodeling in premature newborns.Material and methods. We conducted a retrospective clinical and morphological analysis of 35 deceased premature newborns. During their lifetime, all children were examined using clinical and laboratory-instrumental methods. In all cases, autopsies of deceased children were performed with a complex of morphological studies of the arterial duct.Results. It has been established that the open arterial duct in premature newborns plays an important role in increasing respiratory failure. It also necessitates the appointment and conduct of invasive respiratory therapy. The functioning of the arterial duct is facilitated by low partial pressure and blood oxygen saturation levels. Morphofunctional features of arterial duct remodeling were revealed. A positive correlation was established between the indicators of the gas composition of the child’s blood and the thickness of the duct wall.Conclusion. Risk factors for an open arterial duct in premature newborns are the age of the mother over 35 years, threatened miscarriage, prenatal discharge of amniotic fluid, gestational diabetes mellitus, fetoplacental insufficiency, and severe asphyxia at birth. Morphological changes in the form of thickening of the endothelial layer and the formation of intimal pillows, fragmentation and focal necrosis of the internal elastic membrane with the accumulation of mucoid matter, proliferation and migration of smooth muscle cells into the subendothelial space reflect the processes of remodeling of the arterial duct.

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CCN3 secreted by prostaglandin E2 inhibits intimal cushion formation in the rat ductus arteriosus

Cited by 3 publications

References 23 publications

Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

Patent Ductus Arteriosus in the Preterm Infant

Clinical and morphological features of arterial duct in premature newborns

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