Neonatal cholelithiasis in Down syndrome: Is hypothyroidism involved? A case-report

Ricci, Francesca; Stagi, Stefano; Messa, Federica; Martino, Marco De

doi:10.3233/npm-181

Cited by 3 publications

(1 citation statement)

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“…The incidence of gallstone disease in children is influenced by both genetic and environmental factors, such as exposure to certain drugs, e.g., ceftriaxone or octreotide. In addition, the presence of predisposing diseases can contribute to the formation of gallstones (such as primary sclerosing cholangitis [ 66 ], Wilson disease [ 67 ], renal stones [ 68 ], congenital nephrotic syndrome [ 69 ], hypothyroidism [ 70 ], Down syndrome [ 71 , 72 ], cystic fibrosis [ 73 ], Gaucher disease [ 74 , 75 ]). In recent years, there have been many studies on gallstone disease in children.…”

Section: Discussionmentioning

confidence: 99%

The Etiology of Cholelithiasis in Children and Adolescents—A Literature Review

Zdanowicz

Daniluk

Lebensztejn

et al. 2022

IJMS

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The incidence of gallstone disease has increased in recent years. The pathogenesis of cholelithiasis is not fully understood. The occurrence of the disease is influenced by both genetic and environmental factors. This article reviews the literature on cholelithiasis in children, with the exception of articles on hematological causes of cholelithiasis and cholelithiasis surgery. The aim of this review is to present the latest research on the pathogenesis of gallstone disease in children. The paper discusses the influence of all factors known so far, such as genetic predisposition, age, infections, medications used, parenteral nutrition, and comorbidities, on the development of gallstone disease. The course of cholelithiasis in the pediatric population is complex, ranging from asymptomatic to life-threatening. Understanding the course of the disease and predisposing factors can result in a faster diagnosis of the disease and administration of appropriate treatment.

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