Tattoo-associated complications of metastatic melanoma treated with dabrafenib and trametinib

Laske, J.; Meier, Friedegund; Bauer, Andrea S.; Beissert, Stefan; Garzarolli, Marlene

doi:10.1097/cmr.0000000000000486

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…To the best of our knowledge, only six cases of skin reaction to tattoos during BRAF and MEK inhibitor therapy, like with our patient, have been reported in the literature: three of them describe directly granulomatous findings at biopsy [21][22][23] and the other ones only mild lymphocytic infiltrations [24][25][26]. There are no cases reported in the literature of skin reactions to tattooing during alternative target therapies for melanoma such as Vemurafenib and Cobimetinib.…”

Section: Discussionmentioning

confidence: 53%

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Baratta,

Cazzato,

Foti

et al. 2024

JCM

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Tattoo-associated cutaneous reactions have become quite frequent given the increasing percentage of tattooed subjects globally and also in Italy. On the other hand, the increasing use of target therapy is showing the ability of these drugs to affect the immune system and also cause adverse tattoo-related reactions. In this paper, we report a case of a 42-year-old patient with stage-IIID melanoma undergoing treatment with Dabrafenib and Trametinib. The patient reported erythema, oedema and scaling in areas of the body containing a black tattoo, and, conversely, no signs and/or symptoms in areas with tattoos of a different color. Histopathological and immunohistochemical features indicated a lympho-histiocytic reaction with a granulomatous morphology, mainly distributed around the vessels and hair adnexa. By discussing the cases reported in the literature prior to ours, we concluded and provided the possible indications of the pathogenesis.

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Section: Discussionmentioning

confidence: 53%

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Baratta,

Cazzato,

Foti

et al. 2024

JCM

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“…Up to 1/4 of the administrated pigment can be recovered by the regional lymph nodes, 22 which leads to their colouring, and maybe also to misinterpretations of metastatic melanomas. 23 Metal particles of inks are of the submicron or nanoscale (down to 20 nm) and also reach other organs (e.g., the liver) via the blood stream. 22,[24][25][26][27] Pigments in mouse skin are captured by macrophages and to a lesser extend also by fibroblasts.…”

Section: Physiology Of Tattoosmentioning

confidence: 99%

“…About 1/3 of the ink was cleared within 42 days after tattooing, and sunlight or laser irradiation reduces the amount of pigments in the skin even further to about 1/3 remaining deposits. Up to 1/4 of the administrated pigment can be recovered by the regional lymph nodes, 22 which leads to their colouring, and maybe also to misinterpretations of metastatic melanomas 23 . Metal particles of inks are of the submicron or nanoscale (down to 20 nm) and also reach other organs (e.g., the liver) via the blood stream 22,24–27 .…”

Section: Introductionmentioning

confidence: 99%

Hypersensitivity to permanent tattoos: Literature summary and comprehensive review of patch tested tattoo patients 1997–2022

2023

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We outline constituents of tattoo and permanent make-up ink with regard to inflammatory tattoo reactions and population-based confounders. The comprehensive review of patch-tested tattoo patients between 1997 and 2022 shows that tattoo allergy cannot be reliably diagnosed via patch testing with today's knowledge. Weak penetration and slow haptenization of pigments, unavailability of pigments as test allergens and a lack of knowledge concerning relevant epitopes hamper the diagnosis of tattoo allergy. Patch testing p-phenylenediamine and disperse (textile) dyes is not able to close this gap. Sensitization to metals was associated with all types of tattoo complications, although often not clinically relevant for the tattoo reaction. Binders and industrial biocides are frequently missing on ink declarations and should be patch tested. The pigment carbon black (C.I. 77266) is no skin sensitizer. Patch tests with culprit inks were usually positive with cheap ink products for non-professional use or with professionally used inks in patients with eczematous reactions characterized by papules and infiltration. Tape stripping before patch testing and patch test readings on Day 8 or 10 may improve the diagnostic quality. The meaningfulness of the categorical EU-wide ban of Pigment Green 7 and Pigment Blue 15:3 is not substantiated by the presented data.

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Dabrafenib/trametinib

2018

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Tattoo-associated complications of metastatic melanoma treated with dabrafenib and trametinib

Cited by 5 publications

References 9 publications

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features

Hypersensitivity to permanent tattoos: Literature summary and comprehensive review of patch tested tattoo patients 1997–2022

Dabrafenib/trametinib

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