Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity

Abstract

Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. The typical cytological feature of GCT on FNA smears is highly cellular dual cell pattern consisting of mononuclear stromal cells and multinucleate osteoclast-like giant cells. By performing FNA of the left lobe of thyroid and clinico-radiological evaluation, we were able to diagnose a mass in a 40-year-old male patient as GCT based on cytological specimen. To the best of our knowledge, this is the first case that a GCT is identified in the thyroid gland by FNA initially.

Giant cell tumor of thyroid cartilage: A diagnostic dilemma on aspiration cytology

“…Cytological diagnosis of GCT involving thyroid has rarely been described in the literature. 9 Cellular smears with presence of multinucleated osteoclastic giant cells and mononuclear cells in fibroblastic rich, loose, hemorrhagic, vascular stroma is typical of GCT. The index case showed these typical features.…”

Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine‐needle aspiration cytology

“…FNAC has been shown to achieve an accuracy of over 90% in the diagnosis of STNs . It has been postulated that the increasing number of STNs over time may be attributed to the improved experiences in performing USG thyroid FNAC .…”

“…FNAC has been shown to achieve an accuracy of over 90% in the diagnosis of STNs. 10 It has been postulated that the increasing number of STNs over time may be attributed to the improved experiences in performing USG thyroid FNAC. 1 However, metastatic disease involving the thyroid may be a diagnostic problem, especially many years after the primary tumor.…”