The Value of &lt;sup&gt;18&lt;/sup&gt;F-FDG PET in the Diagnosis of Intertrabecular Vertebral Metastasis in a Small Cell Lung Cancer Patient with a High Serum CEA Level

Morita, Shinichi; Suda, Takafumi; Oda, Chiyumi; Kobayashi, Masaaki; Hoshi, Takahiro; Kanefuji, Tsutomu; Yagi, Kazuichi; Hasegawa, Go; Terai, Shuji

doi:10.2169/internalmedicine.1394-18

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…The median survival from presentation of SCLC was 33 weeks, but only 6 weeks from SCC. In addition, several cases in the literature of spine or spinal cord metastasis from SCLC were also reviewed, [19][20][21][22][23][24][25][26][27] and the main results are shown in Table 3. The survival time of those cases after spinal metastasis ranged from 6 days to 20 months.…”

Section: Discussionmentioning

confidence: 99%

<p>Surgical Treatment of Spinal Cord Compression Caused by Metastatic Small Cell Lung Cancer: Ten Years of Experience in a Single Center</p>

Gào

Zhang

Cao

et al. 2020

CMAR

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Metastatic spinal cord compression (SCC) secondary to small cell lung cancer (SCLC) is a disastrous oncological emergency, but it is poorly understood due to the small numbers of patients and their short survival times. Whether patients suffered from SCC caused by metastatic SCLC benefit from spinal surgery remains unknown. The aim of this study was to evaluate the role of surgical treatment and prognostic factors in patients with SCC caused by metastatic SCLC. Methods: From 2009 to 2019, 30 consecutive patients surgically treated for metastatic SCC from SCLC were enrolled in this retrospective analysis. Kaplan-Meier method and Cox regression analysis were used to estimate overall survival (OS) and identify prognostic factors. Quality of life (QoL) was assessed by the three-level EuroQol-five-Dimensions (EQ-5D-3L) instrument and compared using Student's t test. Results: The median OS time was 9 months in our series. Relief of pain, preservation of neurological function, and improvement of performance status were achieved after surgical intervention. The mean EQ-5D-3L utility score showed a significant improvement after surgery (0.3394 preoperatively vs 0.5884 postoperatively). According to Cox regression analysis, postoperative ECOG-PS and immunotherapy were identified to be independent prognostic factors for patients with SCC caused by metastatic SCLC. Conclusion: Despite the short life expectancy, prompt surgical decompression is extremely necessary for patients with SCC caused by SCLC, for surgery played a critical role in improving patients' QoL. Better performance status after surgery and receiving immunotherapy were associated with a longer OS.

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Section: Discussionmentioning

confidence: 99%

<p>Surgical Treatment of Spinal Cord Compression Caused by Metastatic Small Cell Lung Cancer: Ten Years of Experience in a Single Center</p>

Gào

Zhang

Cao

et al. 2020

CMAR

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“…Chen F et al [50] 2015 NS Lymph node CYFRA21-1, CEA Lee DS et al [51] 2012 NSCLC Brain CEA Morita S et al [52] 2019 NSCLC Intertrabecular Vertebral CEA Shetty D et al [53] 2016 NSCLC Thyroid gland, lymph node PSMA Abbreviations: NS, not specific; NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma antigen; CLSTN1, calsyntenin-1; CLU, clusterin; NGAL, neutrophil gelatinase-associated lipocalin; SNP, single nucleotide polymorphisms; PD-L1, programmed cell death-1; B7-H3, B7 homolog 3; PSMA, prostate-specific membrane antigen.…”

Section: Ca-125mentioning

confidence: 99%

CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis

Li¹,

Yuan²,

Zou³

et al. 2020

J. Cancer

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Despite recent improvements in diagnosis and therapy, lung cancer remains the most common malignant tumor in males, with high morbidity and mortality. As the annual incidence continues to increase worldwide, the prognosis for male patients with lung cancer remains unsatisfactory. Interestingly, smoking is associated with lung cancer and ocular lesions by altering risk factors such as carbohydrate antigen (CA)-125, CA-153 and cytokeratin-19 fragment (CYFRA21-1). A diagnostic standard for serum biomarker levels of ocular metastasis (OM) in males with lung cancer is therefore urgently needed. In this retrospective analysis, we examined the relationship between smoking preference and OM in male patients with lung cancer to identify an independent prognostic factor or establish a quantitative indicated standard for OM using the clinical indexes from 2238 cases of male lung cancer. The combination of CA-125, CA-153 and CYFRA21-1 could help diagnose OM in male lung cancer patients. This finding might lead to more timely diagnosis and effective therapies.

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“…Secondly, the participants were from the same hospital, which may limit the generalizability of our results. Disease Markers [38] 2004 Adenocarcinoma Liver AFP Cabreraalarcon [39] 2011 NS NS CYFRA21-1 Lee [30] 2012 NSCLC Brain CEA Chen [31] 2015 NS Lymph node CYFRA21-1, CEA Chen [40] 2015 NSCLC Brain NSE Zhou [41] 2017 NS Bone CA-125, ALP Morita [42] 2019 NSCLC Intertrabecular vertebral CEA NS: not specific; NSCLC: non-small-cell lung cancer.…”

Section: Disease Markersmentioning

confidence: 99%

Assessment of Serum Tumor Markers for Predicting Ocular Metastasis in Lung Adenocarcinoma: A Retrospective Study

Shi

Liu

et al. 2020

Disease Markers

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The purpose of this study was to detect clinical variations between lung adenocarcinoma patients with and without ocular metastasis (OM) to identify risk factors for OM and assess the diagnostic values. We included 1153 patients with lung adenocarcinoma in this study. Independent t-tests and chi-square tests were used to compare patients’ clinical characteristics. Statistically significant parameters were analyzed by binary logistic regression to detect risk factors of OM. The results showed that the OM group had increased alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), carbohydrate antigen- (CA-) 125, CA-153, and total prostate-specific antigen (TPSA) compared with the NOM group. CYFRA21-1 is the most useful biomarker for detecting OM in this population.

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The Value of <sup>18</sup>F-FDG PET in the Diagnosis of Intertrabecular Vertebral Metastasis in a Small Cell Lung Cancer Patient with a High Serum CEA Level

Cited by 13 publications

References 15 publications

<p>Surgical Treatment of Spinal Cord Compression Caused by Metastatic Small Cell Lung Cancer: Ten Years of Experience in a Single Center</p>

<p>Surgical Treatment of Spinal Cord Compression Caused by Metastatic Small Cell Lung Cancer: Ten Years of Experience in a Single Center</p>

CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis

Assessment of Serum Tumor Markers for Predicting Ocular Metastasis in Lung Adenocarcinoma: A Retrospective Study

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