2018
DOI: 10.1002/jlb.3a0618-223r
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Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury

Abstract: Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic leukocyte-directed acute inflammation-resolving response in cardiac injury. After subacute CAP treatment, mice were subjected to permanent coronary ligation maintaining MI- and naïve-controls. Sp… Show more

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Cited by 25 publications
(13 citation statements)
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“…aspirin), the magnitude of infarction (minor, major, or massive), or ageing. We did not have data on diet or over‐the‐counter medications and recognize that these factors need to be considered in interpreting levels of lipid mediators in plasma of the individual patient . The influence of SES on CV disease is widely recognized.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…aspirin), the magnitude of infarction (minor, major, or massive), or ageing. We did not have data on diet or over‐the‐counter medications and recognize that these factors need to be considered in interpreting levels of lipid mediators in plasma of the individual patient . The influence of SES on CV disease is widely recognized.…”
Section: Discussionmentioning
confidence: 99%
“…We did not have data on diet or over-the-counter medications and recognize that these factors need to be considered in interpreting levels of lipid mediators in plasma of the individual patient. 37,[46][47][48] The influence of SES on CV disease is widely recognized. Although we collected information on education, income, and health insurance, we could not stratify by SES due to the small sample size.…”
Section: Study Limitationsmentioning
confidence: 99%
“…Single mononuclear cells were isolated from the spleen and left ventricle (LV) of wild-type (WT) and FPR2 −/− mice and analyzed by flow cytometry as reported previously (FACs strategy Supplementary Figure 10) [21,22].…”
Section: Methodsmentioning
confidence: 99%
“…The lungs, LV, spleen, plasma, and kidneys were harvested and weighed, and the tibia was collected for the standardization of weights. The samples were kept in 10% zinc formalin for immunohistochemistry or flash frozen for molecular analysis (Halade et al, 2018a, Halade et al, 2018b, Lopez et al, 2015, Zamilpa et al, 2013.…”
Section: Necropsymentioning
confidence: 99%
“…The COX activity assay kit (Cayman Chemical, 760151) was used according to the manufacturer's instructions to determine COX-2 activity in the kidney tissue (Halade et al, 2018b).…”
Section: Cox-2 Activitymentioning
confidence: 99%