Leptin to adiponectin ratio – A surrogate biomarker for early detection of metabolic disturbances in obesity

Larsen, Maria Arlén; Isaksen, Victoria Therese; Moen, Odd Sverre; Wilsgaard, L.; Remijn, M.; Paulssen, Eyvind J.; Florholmen, Jon; Goll, Rasmus

doi:10.1016/j.numecd.2018.06.020

Cited by 25 publications

(29 citation statements)

References 31 publications

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“…In the ARIRANG study, low ratio of L/A is a predictor for the regression of MetS and L/A was proposed as a clinical biomarker to measure the risk to develop the syndrome [103]. Finally, L/A ratio and HOMA-IR index has been demonstrated that both can be used to identify obese patients with IR [104,105].…”

Section: Carbohydrate Dysfunctionmentioning

confidence: 99%

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

et al. 2020

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The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients.

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Section: Carbohydrate Dysfunctionmentioning

confidence: 99%

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

et al. 2020

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“…Adiponectin antagonizes the pro-inflammatory and pro-oncogenic activity of leptin in addition to promoting insulin sensitivity [ 62 ]. Our observed normalization of the adiponectin:leptin ratio in the majority of participants is an indicator of improved metabolic function [ 56 , 66 ]. Omentin-1, which has anti-inflammatory, insulin sensitizing, and tumor suppressive properties, is produced primarily by VAT and its secretion is increased with exercise training [ 63 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors

Fabian

Klemp

Marchello

et al. 2021

Cancers

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Aerobic exercise reduces risk for breast cancer and recurrence and promotes visceral adipose tissue (VAT) loss in obesity. However, few breast cancer survivors achieve recommended levels of moderate to vigorous physical activity (MVPA) without supervision. In a two-cohort study, feasibility of 12 weeks of partially supervised exercise was started concomitantly with caloric restriction and effects on body composition and systemic risk biomarkers were explored. In total, 22 obese postmenopausal sedentary women (including 18 breast cancer survivors) with median age of 60 and BMI of 37 kg/m2 were enrolled. Using personal trainers twice weekly at area YMCAs, MVPA was escalated to ≥200 min/week over 9 weeks. For cohort 2, maintenance of effect was assessed when study provided trainer services were stopped but monitoring, group counseling sessions, and access to the exercise facility were continued. Median post-escalation MVPA was 219 min/week with median 12-week mass and VAT loss of 8 and 19%. MVPA was associated with VAT loss which was associated with improved adiponectin:leptin ratio. In total, 9/11 of cohort-2 women continued the behavioral intervention for another 12 weeks without trainers. High MVPA continued with median 24-week mass and VAT loss of 12 and 29%. This intervention should be further studied in obese sedentary women.

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“…The L/A ratio significantly correlated with WC in the present study. A number of studies have indicated that although leptin or adiponectin had independent associations with the risk of MetS, diabetes, and coronary artery diseases, the diseases were more correlated with the L/A ratio than with leptin or adiponectin alone (31,34,64,65). Furthermore, it was suggested that L/A unbalance could be associated with increased vasoconstriction caused by angiotensin II action (61).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Leptin to Adiponectin Ratio and Metabolic Syndrome Indices in Apparently Healthy Adults

Tarighat‐Esfanjani¹,

Ghadimi²,

Ebrahimi-Mameghani³

et al. 2020

Turk J Endocrinol Metab

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Objective: Leptin/adiponectin (L/A) ratio is considered a predicting factor of metabolic syndrome (MetS) and its related morbidities. In the present study, we determined the association of serum L/A ratio with MetS parameters in apparently healthy Iranian adults. Material and Methods: This cross-sectional study was conducted on 150 apparently healthy adults aged 25 to 50 years, who were selected by random sampling from different medical centers of Tabriz city, Iran. Our criteria for being a healthy individual were based on self-report of the participants. Anthropometric measures, fasting blood sugar (FBS) and lipid profile, systolic and diastolic blood pressure (SBP and DBP), and fasting serum L/A levels were measured. Results: There were significant differences (p<0.05) in weight, height, waist circumference (WC), SBP, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), serum leptin concentration, and L/A ratio between males and females. Univariate linear regression model revealed a significant positive association of serum leptin concentration with WC (p=0.024) and FBS (p=0.046). A similar result was obtained using the multiple regression model after adjusting for confounding factors (p<0.001 and p=0.045). A significant positive correlation was found between the L/A ratio and WC (p=0.010) in the adjusted model. However, no significant association was observed between adiponectin and MetS indices. Conclusion: Our findings indicated a significant positive association of serum leptin concentration with WC and FBS and between L/A ratio and WC in apparently healthy adults. Therefore, compared to adiponectin, leptin, and L/A ratio could be useful predictors of MetS.

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Leptin to adiponectin ratio – A surrogate biomarker for early detection of metabolic disturbances in obesity

Cited by 25 publications

References 31 publications

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors

Relationship Between Leptin to Adiponectin Ratio and Metabolic Syndrome Indices in Apparently Healthy Adults

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