Patient‐Reported Outcomes Predict Mortality in Lupus

Azizoddin, Desiree R.; Jolly, Meenakshi; Arora, Shilpa; Yelin, Ed; Katz, Patricia P.

doi:10.1002/acr.23734

Cited by 24 publications

(15 citation statements)

References 42 publications

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“…Given that SLE can present with a wide range of symptoms, PROMs can allow providers valuable insights into their patients’ disease activity, disease damage, and quality of life. The importance of PROMs in SLE has increased, with research finding that patient‐reported physical function independently predicts mortality in patients with SLE .…”

Section: Systemic Lupus Erythematousmentioning

confidence: 99%

Patient‐Reported Outcomes in Rheumatology Patients With Limited English Proficiency and Limited Health Literacy

Bedoya¹,

Davis²,

Hirsh³

2020

Arthritis Care & Research

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Section: Systemic Lupus Erythematousmentioning

confidence: 99%

Patient‐Reported Outcomes in Rheumatology Patients With Limited English Proficiency and Limited Health Literacy

Bedoya¹,

Davis²,

Hirsh³

2020

Arthritis Care & Research

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“…SLE symptoms, manifestations, and comorbidities impose a high disease burden that is not fully captured by disease activity assessments [ 2 , 4 , 5 ]. Thus, collection of patient-reported outcomes (PROs) as part of routine clinical care and clinical trials is important for gaining a more complete understanding of disease progression and evaluating treatment effectiveness [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Patient-Reported Outcomes from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Repository Corticotropin Injection (Acthar® Gel) for Persistently Active Systemic Lupus Erythematosus

et al. 2021

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Introduction: We assessed patient-reported outcomes from a multicenter, randomized, double-blind, placebo-controlled study of repository corticotropin injection (RCI; Acthar Ò Gel) in patients with persistently active systemic lupus erythematosus (SLE) despite treatment with moderate-dose glucocorticoids. Methods: The trial enrolled adults with active SLE and moderate-to-severe rash and/or arthritis despite use of stable glucocorticoids (7.5 mg/day to 30 mg/day prednisone equivalent), antimalarials, and nonsteroidal anti-inflammatory drugs for C 4 weeks and/or immunosuppressants for C 8 weeks before screening. Patients were randomly assigned to 80 U of RCI or placebo subcutaneously every other day through week 4, then twice weekly through week 24.

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“…[ 2 , 4 - 11 ] Reduced exercise capacity is associated with higher rates of mortality in the general population. [ 6 ] Poor self-reported physical function is an independent predictor of mortality in SLE, even after adjusting for disease duration, disease activity and damage,[ 5 ] indicating that physical function is of importance to measure when monitoring patients with SLE.…”

Section: Introductionmentioning

confidence: 99%

“…Exercise capacity and the level of physical activity and exercise are reduced, also reflected by the fact that individuals with SLE report lower physical capacity such as walking, jogging and running than the general population. 2,[4][5][6][7][8][9][10][11] Reduced exercise capacity is associated with higher rates of mortality in the general population. 6 Poor self-reported physical function is an independent predictor of mortality in SLE, even after adjusting for disease duration, disease activity and damage, 5 indicating that physical function is of importance to measure when monitoring patients with SLE.…”

mentioning

confidence: 99%

Factors Associated With Self-Reported Capacity to Walk, Jog and Run in Individuals With Systemic Lupus Erythematosus

et al. 2020

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Objectives This study aims to explore how disease and health-related quality of life (HRQOL) factors are associated with self-reported physical capacity in walking, jogging and running in systemic lupus erythematosus (SLE). Patients and methods This cross-sectional study is part of an ongoing cohort research project which started in 2014. A total of 198 patients (21 males, 177 females; mean age 51.5±16.1 years; range, 20 to 82 years) with SLE answered a question concerning physical capacity and the answers were categorized as low (can walk less than 2 km) and high (can jog and run at least 2 km) capacity. Additional measurements of disease activity (Systemic Lupus Activity Measure-Revised, SLAM-R), organ damage (Systemic Lupus International Collaborating Clinics-Damage Index, SLICC-DI), physical activity (International Physical Activity Questionnaire-Short Form, IPAQ-SF), exercise during the past year, Hospital Anxiety and Depression Scale (HADS), and HRQOL according to EuroQol five-dimension score and EuroQol visual analog scale (EQ-VAS) were included. The independent variables in the multiple logistic regression analysis were age, body mass index (BMI), disease duration, SLAM-R, SLICC-DI, IPAQ-SF category, sitting hours (IPAQ-SF), and exercise during the past year as well as HADS and EQ-VAS. Results Patients that reported low physical capacity (n=120) were older (p<0.001), had longer disease duration (p<0.001), had more organ damage (p<0.001), reported that they were less physically active (p=0.003), exercised less during the past year (p=0.001), reported more pain/discomfort and depressive symptom (p<0.001) and had lower overall HRQOL (p<0.001) and mobility and usual activities than those that reported high capacity (n=78). The regression analysis showed that age (median ≤49 vs >49) (Exp) (B): 4.52 (95% confidence interval [CI]: 2.05 to 9.98) (p<0.001), disease duration (median ≤17 vs >17) Exp (B): 2.53 (95% CI: 1.15 to 5.60) (p=0.02), SLICC-DI (median <1 vs ≥1) Exp (B): 3.60 (95% CI: 1.48 to 8.73) (p=0.005), and EQ-VAS (median <72 vs ≥72) Exp (B): 4.63 (95% CI: 2.13 to 10.05) (p<0.001) were significant factors associated with physical capacity (Nagelkerke R Squared=0.46). Conclusion Patients with low physical capacity were less physically active, exercised less and had more pain and depressive symptoms than those that reported a high capacity. However, only age, disease duration, organ damage and overall HRQOL were indicators of low physical capacity. In order to increase physical capacity in the management of SLE, it is important to address overall HRQOL.

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Patient‐Reported Outcomes Predict Mortality in Lupus

Cited by 24 publications

References 42 publications

Patient‐Reported Outcomes in Rheumatology Patients With Limited English Proficiency and Limited Health Literacy

Patient‐Reported Outcomes in Rheumatology Patients With Limited English Proficiency and Limited Health Literacy

Patient-Reported Outcomes from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Repository Corticotropin Injection (Acthar® Gel) for Persistently Active Systemic Lupus Erythematosus

Factors Associated With Self-Reported Capacity to Walk, Jog and Run in Individuals With Systemic Lupus Erythematosus

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