Morphology and internal structure control over PLA microspheres by compounding PLLA and PDLA and effects on drug release behavior

Yu, Bowen; Lü, Meng Kai; Fu, Sirui; Zhao, Zhiyu; Liu, Yuhang; Wang, Ke; Fu, Qiang

doi:10.1016/j.colsurfb.2018.08.037

Cited by 42 publications

(31 citation statements)

References 44 publications

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“…In conclusion, the drug release behavior of PLA microspheres can be adjusted by simply modifying the ratio of PLLA to PDLA. Therefore, the combination of various types of PLLA/PDLA microspheres can regulate the drug release rate based on the actual demands [43].…”

Section: Diffusionmentioning

confidence: 99%

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

et al. 2022

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The sustained release of pharmaceutical substances remains the most convenient way of drug delivery. Hence, a great variety of reports can be traced in the open literature associated with drug delivery systems (DDS). Specifically, the use of microparticle systems has received special attention during the past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability of both hydrophilic and lipophilic drug substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and their copolymers are among the most frequently used biodegradable polymers for encapsulated drugs. This review describes the current state-of-the-art research in the study of poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles and PLA-copolymers with other aliphatic acids as drug delivery devices for increasing the efficiency of drug delivery, enhancing the release profile, and drug targeting of active pharmaceutical ingredients (API). Potential advances in generics and the constant discovery of therapeutic peptides will hopefully promote the success of microsphere technology.

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Section: Diffusionmentioning

confidence: 99%

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

et al. 2022

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“…The enantiomeric polymer blend solution can be used for other processing techniques such as electrospining and templated-drying in order to produce SC crystal embedded PLA with complex macroscopic shapes and enhanced final material properties. Electrospinning of PLA blend solution is able to produce a high degree of SC content due to the improved intermolecular ordering between PLLA and PDLA chains from high shear force induced by electric field (Figure 2D) (Yu et al, 2018). Strengthened PLA-based materials with improved thermal (melting temprature over 200 • C) and mechanical properteis (Young's modulus up to 270 MPa) are prepared by the electrospinning of a PDLA-grafted chitosan (PDLA-CTC) /PLLA mixture, in which SC formation is assisted by intermolecular hydrogen bonding interactions between stereoisomers.…”

Section: Solution Castingmentioning

confidence: 99%

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

et al. 2020

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The production and utilization of polymers have been widely implemented into diverse applications that benefit modern human society, but one of the most valuable properties of polymers, durability, has posed a long-standing environmental challenge from its inception since plastic waste can lead to significant contamination and remains in landfills and oceans for at least hundreds of years. Poly(lactic acid) (PLA) derived from renewable resources provides a sustainable alternative to traditional polymers due to its advantages of comparable mechanical properties with common plastics and biodegradability. However, the poor thermal and hydrolytic stability of PLA-based materials limit their potential for durable applications. Stereocomplex crystallization of enantiomeric poly (l-lactide) (PLLA) and poly (d-lactide) (PDLA) provides a robust approach to significantly enhance material properties such as stability and biocompatibility through strong intermolecular interactions between L-lactyl and D-lactyl units, which has been the key strategy to further PLA applications. This review focuses on discussing recent progress in the development of processing strategies for enhancing the formation of stereocomplexes within PLA materials, including thermal processing, additive manufacturing, and solution casting. The mechanism for enhancing SC formation and resulting material property improvement enabled by each method are also discussed. Finally, we also provide the perspectives on current challenges and opportunities for improving the understanding of processing-structure-property relationship in PLA materials that could be beneficial to their wide practical applications for a sustainable society.

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“…Besides the content of SCs particles constructed by aggregated SCs, enlarging their surface area is also beneficial to the enhancement in their nucleating effect. [42][43][44] In this regard, much attention has been paid to sufficiently controlling the particle size and dispersion level of the SCs formed in asymmetric PLLA/PDLA blends with low concentration (e.g., 0.5-1.5 wt%) PDLA, [45][46][47] while suppressing the SCs networking. For example, Kim and co-workers [46] proposed an interesting approach to synthesize PLA having excellent nucleation efficiency (NE) via ring-opening polymerization of L-lactide monomers in the presence of small SCs particles (700-3900 nm) that was preprepared by a complex supercritical fluid technology.…”

Section: Introductionmentioning

confidence: 99%

Importance of Low‐Temperature Melt‐Mixing on the Construction of Stereocomplex Crystallites with Superior Nucleation Efficiency in Asymmetric Poly(l‐lactide)/Poly(d‐lactide) Blends

Zeng

Bai

et al. 2021

Macro Materials & Eng

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The nucleation efficiency (NE) of stereocomplex crystallites (SCs) formed in asymmetric poly(L‐lactide)/poly(D‐lactide) (PLLA/PDLA) blends is generally unsatisfactory because the competition between stereocomplexation and chain mixing involved in the melt‐mixing process can cause low formation efficiency and even severe aggregation of SCs. Herein, it is attempted to achieve high‐efficient formation of finely dispersed SCs particles by designing a unique melt‐mixing procedure, where the mixing of PLLA with 0.75 wt% PDLA is first performed at elevated temperatures (far above the melting temperature of SCs) to allow the homogeneous mixing of PLLA/PDLA chains and then at a low temperature (slightly above that of homocrystallites) to permit the full stereocomplexation of the premixed chains. It is found that the SCs formed in the blends exhibit unexpectedly low NEs (e.g., 54.5%), much inferior to that (73.6%) in the counterpart without undergoing premixing. This is because the introduction of premixing leads to a remarkable deterioration in the amount of SCs particles formed, despite decreased particle size, highlighting that the direct mixing at low temperatures of 170–180 °C (about 20–30 °C lower than that used in common melt‐processing of PLA) is more effective for the construction of SCs with superior NE. The mechanisms for these striking findings are discussed.

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Morphology and internal structure control over PLA microspheres by compounding PLLA and PDLA and effects on drug release behavior

Cited by 42 publications

References 44 publications

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

Importance of Low‐Temperature Melt‐Mixing on the Construction of Stereocomplex Crystallites with Superior Nucleation Efficiency in Asymmetric Poly(l‐lactide)/Poly(d‐lactide) Blends

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