Moderate-to-heavy smoking in women is potentially associated with compromised cortical porosity and stiffness at the distal radius

Johnson, Joshua E.; Troy, Karen L.

doi:10.1007/s11657-018-0504-y

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…Cigarette smoke has many compounds harmful to the human body. 1 2 3 4 Nicotine is an addictive part contained in these cigarettes and has deleterious influence on many vital organs. 1 4 5 The effect of cigarette smoking on bone metabolism has been reported in many studies that observed that bone density is reduced in elderly and postmenopausal smokers.…”

Section: Introductionmentioning

confidence: 99%

“…1 4 5 The effect of cigarette smoking on bone metabolism has been reported in many studies that observed that bone density is reduced in elderly and postmenopausal smokers. 3 6 Nicotine causes vasoconstriction and tissues hypoxemia, thus delaying fracture healing. 7 8 Nonunion, delayed union, and residual pain are the complications of smoking associated with fracture healing.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Smoking in the Clinical Outcomes of Distal Radius Fractures

Kaneko

Naïto

Obata

et al. 2022

Journal of Hand and Microsurgery

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Introduction There are various studies that reviewed the effect of cigarette smoking in fracture healing process. Nonunion, delayed union, and residual pain are the significant risk factors associated with smoking and fracture healing. Little has been known about the impact of smoking in distal radius fracture healing. We intend to explore in brief the effect of smoking in distal radius fracture healing and comparing it with nonsmokers having the same fracture fixation and analyze the outcomes with respect to fracture healing and return of function. Materials and Methods Of the total 186 patients, 92 were included in the study with (n = male: 31, female: 61) mean age of 60.2 years. They were divided into two groups: smoking (n = 43) and nonsmoking (n = 49). All had surgical fixation of the distal radius with volar locking plate and started on early mobilization. The range of motion of the wrist, grip, visual analog scale, quick disabilities of the arm and shoulder and hand score, Mayo wrist score, and bone healing period were noted between these two groups and compared with statistical analysis. Results The mean follow-up period was 8.7 months. There was a significant association of young age and male patients having distal radius fractures in the smoking group (p < 0.05). All fractures healed well in both groups without complications. There was no significant difference between these two groups in terms of range of motion, grasp, bone healing period, and functional outcomes. Conclusion Despite the well-known fact that, smoking has negative implications in the fracture healing process, we found group of patients (smoking and nonsmoking) with distal radius fractures treated by volar locking plates healed well with good radiological union and excellent functional outcome There is no significant influence of smoking in distal radius fracture fixation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Smoking in the Clinical Outcomes of Distal Radius Fractures

Kaneko

Naïto

Obata

et al. 2022

Journal of Hand and Microsurgery

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“…In 2012 alone, the global cost of smoking-attributable diseases (excluding second-hand smoking) was equivalent to 5.7% of the global health expenditure [3]. In addition to being a risk factor for poor bone mineral density [4] and increased cortical porosity [5], the effects of smoking on periodontal health are well-documented [6,7]. Although dental rehabilitation using osseointegrated implants is a reliable treatment modality with high survival rates [8,9], smoking can modulate the expression of osteogenic and inflammatory factors in alveolar bone [10], implant-adherent cells [11], and in the peri-implant crevicular fluid [12,13].…”

Section: Introductionmentioning

confidence: 99%

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

et al. 2019

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Smoking is a major risk factor for dental implant failure. In addition to higher marginal bone loss around implants, the cellular and molecular responses to injury and implant physicochemical properties are also differentially affected in smokers. The purpose of this work is to determine if smoking impairs bone microstructure and extracellular matrix composition within the dental alveolar socket after tooth extraction. Alveolar bone biopsies obtained from Smokers (> 10 cigarettes per day for at least 10 years) and Ctrl (never-smokers), 7-146 months after tooth extraction, were investigated using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, and Raman spectroscopy. Both Smokers and Ctrl exhibited high inter-and intra-individual heterogeneity in bone microstructure, which varied between dense cortical and porous trabecular architecture. Regions of disorganised/woven bone were more prevalent during early healing. Remodelled lamellar bone was predominant at longer healing periods. Bone mineral density, bone surface-to-volume ratio, mineral crystallinity, the carbonate-to-phosphate ratio, the mineral-to-matrix ratio, the collagen crosslink ratio, and the amounts of amino acids phenylalanine and proline/hydroxyproline were also comparable between Smokers and Ctrl. Bone microstructure and composition within the healing dental alveolar socket are not significantly affected by moderate-to-heavy smoking.

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