Association of HIV status with infection by multiple HPV types

Camargo, Milena; Río‐Ospina, Luisa Del; León, Sara Cecilia Soto-De; Sánchez, Ricardo; Pineda-Peña, Andrea-Clemencia; Sussmann, Otto; Patarroyo, Manuel Elkín; Patarroyo, Manuel A.

doi:10.1111/tmi.13142

Cited by 19 publications

(26 citation statements)

References 35 publications

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“…The most common reason for exclusion was absence of specified age for participants because most studies reported minimum age for inclusion but no average, median, or range (Supplementary File 2). We selected 19 cross-sectional studies 20–38 ; four of these studies corresponded to analysis nested in cohort studies. We did not find any longitudinal analyses that met the eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

“…The oldest study was published in 1999 31 and the most recent in 2018. 22,38 Most studies were published during the last decade.…”

Section: Resultsmentioning

confidence: 99%

“…Combined methods were observed in four studies: one study used Hybrid capture II and PCR linear array, 29 and the other three studies used MY09/11 and GP5+/GP6+. 25,37,38…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies included an HIV-negative control group (1213 women). 28,38 The average sample size was 324 (range 20–802) (Table 1). Four studies reported average age between 30 and 34 years old, three reported average age between 35 and 39 years old, and four reported average age over 40 years old.…”

Section: Resultsmentioning

confidence: 99%

“…HPV prevalence among WLHIV (68.3% and 70.0%) was higher than prevalence among HIV-negative women (21.2% and 43.6%), as reported by two publications. 28,38 Upon request, four studies provided disaggregated data by age. 20,28,29,34 HR-HPV prevalence by age shows a bimodal distribution with an initial peak in women aged 10–19 years old and a trend back upward for women aged 60–64 (Figure 4).…”

Section: Resultsmentioning

confidence: 99%

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High-risk human papillomavirus infection among women living with HIV in Latin America and the Caribbean: A systematic review and meta-analysis

et al. 2021

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We carried out a systematic review to summarize available data regarding prevalence of high-risk human papillomavirus (HR-HPV) among women living with HIV (WLHIV) in Latin America and the Caribbean (LAC). A literature search in PubMed and LILACS was conducted and supplemented with cross-referencing and grey literature. The primary outcome was prevalence of HR-HPV by age as a major determinant of HPV infection. Pooled prevalence and weighted averages were obtained. A random effects meta-analysis conducted for HPV- and HIV-associated factors. In total, 6157 women from 19 cross-sectional studies were included. Weighted prevalence of HR-HPV in WLHIV was 51.0% (95% CI 42.8–59.1, I2 = 97.4%) with a bimodal trend by age. No association between antiretroviral therapy and HR-HPV prevalence was observed, but low CD4 cell count was associated (PR 1.64, 95% CI 1.07–2.52). Although not significant, a higher HR-HPV prevalence was observed with Hybrid Capture 2 versus PCR. The high prevalence of HR-HPV among WLHIV in LAC underlines the need for improved cervical cancer prevention and early detection in this vulnerable population. Moreover, the high prevalence across age groups, and particularly in young women, deserves careful consideration for defining target populations of HPV-based screening and HPV immunization programs.

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Section: Resultsmentioning

confidence: 99%

“…The oldest study was published in 1999 31 and the most recent in 2018. 22,38 Most studies were published during the last decade.…”

Section: Resultsmentioning

confidence: 99%

“…Combined methods were observed in four studies: one study used Hybrid capture II and PCR linear array, 29 and the other three studies used MY09/11 and GP5+/GP6+. 25,37,38…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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High-risk human papillomavirus infection among women living with HIV in Latin America and the Caribbean: A systematic review and meta-analysis

et al. 2021

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Respective prevalence of high‐risk HPVgenotypes in cervical neoplasia in Senegal

Diop‐Ndiaye

Sastre-Garau

Dramé

et al. 2021

Journal of Medical Virology

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Objectives With the perspective of prophylactic vaccination against high‐risk human papillomavirus (HPV), we analyzed the viral epidemiology of cervical neoplasia in Senegal. Methods All patients were treated at the Institut Joliot Curie du Cancer in Dakar. HPV genotypes were characterized using a real‐time polymerase chain reaction‐based approach and sequencing. Results Histologically, there were 224 invasive carcinomas, 17 high‐grade intraepithelial neoplasia (CIN), and five undetermined histologies. Molecular analysis was conclusive in 241 cases. HPV DNA was found in 207/241 (85.9%) cases while 34/241 (14.1%) remained HPV negative. There was one single genotype in 127/207 (61.4%) cases and several in 80/207 (38.6%) corresponding to 308 genotypes identified. Viral genotyping found HPV16 in 175 (56.8%) cases, HPV18 in 45 (14.6%), HPV45 in 40 (13.0%), HPV58 in 35 (11.4%), HPV33 in 6 (2.0%), HPV35 in 3 (1.0%), HPV31 in 2 (0.6%), HPV39 and HPV56 in one (0.3% each). Conclusion Our analysis showed that 98.4% of the HPV‐positive cases were associated with viral genotypes covered by the 9‐valent HPV vaccine. However, 14.1% of cases remained HPV negative. Therefore, prophylactic vaccination using a 9‐valent vaccine should dramatically reduce the incidence of HPV‐associated neoplasia but the detection and treatment of CIN remain necessary for the optimal prevention of cervical cancer.

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HPV co‐infections with other pathogens in cancer development: A comprehensive review

Akbari,

Milani,

Seyedinkhorasani

et al. 2023

Journal of Medical Virology

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High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co‐infecting agents that influence infection dynamics and disease progression. Bacterial co‐infections (e.g., Chlamydia trachomatis) along with bacterial vaginosis‐related species also interact with HPV in genital tract leading to viral persistence and disease outcomes. Co‐infections involving HPV and diverse infectious agents have significant implications for disease transmission and clinical progression. This review explores multiple facets of HPV infection encompassing the co‐infection dynamics with other pathogens, interaction with the human microbiome, and its role in disease development.

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Association of HIV status with infection by multiple HPV types

Cited by 19 publications

References 35 publications

High-risk human papillomavirus infection among women living with HIV in Latin America and the Caribbean: A systematic review and meta-analysis

High-risk human papillomavirus infection among women living with HIV in Latin America and the Caribbean: A systematic review and meta-analysis

Respective prevalence of high‐risk HPVgenotypes in cervical neoplasia in Senegal

HPV co‐infections with other pathogens in cancer development: A comprehensive review

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