Effect of Physical Activity on Frailty

Trombetti, Andrea; Hars, Mélany; Pahor, Marco; McDermott, Mary M.; Fielding, Roger A.

doi:10.7326/l18-0243

Cited by 4 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings indicate that sedentary behavior reduction might serve as an intervention target for frailty prevention. In 2018, the effects of a physical activity program tailored to older adults, with the goal of reaching 150 min•wk −1 of moderate-intensity activity, on frailty were tested (33). The physical activity program, which largely consisted of walking but also included strength, balance, and flexibility, was not associated with frailty reduction over 24 months.…”

Section: Discussionmentioning

confidence: 99%

“…There was lower adherence at 24 months (66% session attendance) compared with 6 months (76% session attendance), possibly explaining the null findings at 24 months. Lower adherence might be explained through difficulty in transitioning from supervised (center-based) to unsupervised (home-based) exercise participation (34), a feature built into the physical activity intervention (33,35). Our observational findings support this hypothesis, suggesting that higher daily activity at lower intensities, perhaps achieved by decreasing at-home sitting-like behaviors, might be a manageable alternative pathway or complement to meeting current physical activity guidelines (36) that potentially combats frailty.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence

Wanigatunga

Chiu

Cai

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Introduction: Low physical activity is a criterion of phenotypic frailty defined as an increased state of vulnerability to adverse health outcomes. Whether disengagement from daily all-purpose physical activity is prospectively associated with frailty and possibly modified by chronic inflammation-a pathway often underlying frailty-remains unexplored. Methods: Using the Study to Understand Fall Reduction and Vitamin D in You data from 477 robust/prefrail adults (mean age = 76 ± 5 yr; 42% women), we examined whether accelerometer patterns (activity counts per day, active minutes per day, and activity fragmentation [broken accumulation]) were associated with incident frailty using Cox proportional hazard regression. Baseline interactions between each accelerometer metric and markers of inflammation that include interleukin-6, C-reactive protein, and tumor necrosis factor-alpha receptor 1 were also examined. Results: Over an average of 1.3 yr, 42 participants (9%) developed frailty. In Cox regression models adjusted for demographics, medical conditions, and device wear days, every 30 min•d −1 higher baseline active time, 100,000 more activity counts per day, and 1% lower activity fragmentation was associated with a 16% (P = 0.003), 13% (P = 0.001), and 8% (P < 0.001) lower risk of frailty, respectively. No interactions between accelerometer metrics and baseline interleukin-6, C-reactive protein, or tumor necrosis factor-alpha receptor 1 were detected (interaction P > 0.06 for all). Conclusions: Among older adults who are either robust or prefrail, constricted patterns of daily physical activity (i.e., lower total activity minutes and counts, and higher activity fragmentation) were prospectively associated with higher risk of frailty but not modified by frailty-related chronic inflammation. Additional studies, particularly trials, are needed to understand if this association is causal.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence

Wanigatunga

Chiu

Cai

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

show abstract

“…These interventions include physical exercise, nutrition, cognitive training, psychological support, and socio-economic support [17][18][19]. Physical exercise is the preferred option for preventing and treating frailty in the older adults [20]. The combination of resistance and balance exercise in physical exercise forms can improve the lower limb muscle strength and balance ability of frail older adults people.…”

Section: Introductionmentioning

confidence: 99%

The influence of physical exercise on the loneliness of the older adults: the mediating role of frailty and depression

Gu,

Liu

2024

Preprint

View full text Add to dashboard Cite

Background Frailty, depression, and loneliness are risk factors for successful aging. Physical exercise is an important method to promote the physical and mental health of the older adults. Guided by the integral conceptual model of frailty, this study constructed a mediating model to examine the influence of physical exercise on the loneliness of the older adults, as well as determine the mediating role of frailty and depression between them. Methods In this descriptive and cross-sectional study, a questionnaire survey was conducted on 505 older adults individuals aged 60 and above in China from February to July 2023. The data were collected using the Physical Activity Rating Scale (PARS-3), the UCLA Loneliness Scale (ULS-8), the Tilburg Frailty Indicator (TFI) and the Patient Health Questionnaire-9 (PHQ-9). The collected data was analyzed for mediating effects using the SPSS macro program PROCESS v4.0, Model 6. Results Physical exercise negatively predicted frailty, depression, and loneliness in the older adults (β = -0.414, P < 0.01; β = -0.248, P < 0.01; and β = -0.194, P < 0.01, respectively). Physical exercise affects loneliness through four paths: direct effect, the mediating effect of frailty, the mediating effect of depression, and serial multiple mediating effect of frailty and depression. The mediating effect model explained 58.55% of the variation in loneliness. Conclusions Physical exercise can not only improve the frailty of the older adults but also alleviate the depression caused by the decline in their physiological and social functions, thereby comprehensively improving their loneliness. From the perspective of frailty, we could identify high-risk groups for depression and loneliness and find targeted interventions based on the type of frailty (social, psychological, and physiological), such as participating in collective physical exercise and combining physical exercise interventions with antidepressant medication or nutrition interventions. The results of this study can help older adults people manage their health and improve their physical and mental state.

show abstract

Effect of Multidomain Intervention, Omega-3 Polyunsaturated Fatty Acids Supplementation or their Combinaison on Cognitive Function in Non-Demented Older Adults According to Frail Status: Results from the MAPT Study

Tabué-Teguo

Souza

Cantet

et al. 2018

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Effect of Physical Activity on Frailty

Cited by 4 publications

References 6 publications

Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence

Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence

The influence of physical exercise on the loneliness of the older adults: the mediating role of frailty and depression

Effect of Multidomain Intervention, Omega-3 Polyunsaturated Fatty Acids Supplementation or their Combinaison on Cognitive Function in Non-Demented Older Adults According to Frail Status: Results from the MAPT Study

Contact Info

Product

Resources

About