Spontaneous ascending aortic rupture in a pregnant woman with neurofibromatosis type 1

Tateishi, Atsushi; Okada, Masahiro; Nakai, Masatsugu; Yokota, Yutaka; Miyamoto, Yukio

doi:10.1007/s11748-018-0989-8

Cited by 5 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two pathogenic mechanisms may account for the uncommon spontaneous aortic rupture in these cases: smooth muscle dysplasia and direct vascular invasion by neurofibromatous tissue, as well as ganglioneuromatous tissue invading the arterial wall. There was one case of spontaneous ascending aortic rupture in a pregnant woman with NF-1 in our review [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Antepartum acute Stanford type A aortic dissection: a case report and literature review

Song

Lü

et al. 2022

J Cardiothorac Surg

View full text Add to dashboard Cite

Background Aortic dissection in pregnancy is a life-threatening event that is associated with high maternal and foetal mortality. Most cases occur during the third trimester of pregnancy, Herein, we describe a case of a pregnant woman with acute type A aortic dissection at 28 weeks of gestation. Case presentation A previously healthy, 24-year-old gravida 2 para 1 woman was brought to the emergency department during at the 28 weeks of gestation and diagnosed with acute type A aortic dissection. Cesarean section was performed with the cardiac surgical team on standby for cardiopulmonary bypass and the patient delivered a baby weighing 1000 g. After the operation, we performed the Beatall procedure and total arch replacement with FET using the deep hypothermic circulatory arrest technique. Both the mother and child survived and recovered well. A review of the literature on antepartum acute aortic dissection during pregnancy is also presented. Conclusion Women should have a comprehensive, systematic physical examination before getting pregnant. Women at high risks of aortic dissection must undergo multidisciplinary evaluation and be counseled before pregnancy, once they become pregnant, their consistent aortic root diameter should be consistently monitored, and their blood pressure strictly controlled.

show abstract

Section: Discussionmentioning

confidence: 99%

Antepartum acute Stanford type A aortic dissection: a case report and literature review

Song

Lü

et al. 2022

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…Several studies have suggested that risk factors for its onset included age over 40, smoking, hypertension, aortic dysplasia, Marfan syndrome and autosomal dominant connective tissue disease ( 10 , 11 ). Atsushi et al reported a case of spontaneous rupture of a thoracic aortic aneurysm that happened in a pregnant woman with type I neurofibromatosis, an autosomal dominant connective tissue diseaseat, at 30 weeks of gestation ( 12 ). Several studies have also suggested that diabetes may be a risk factor for AAA, although this has remained to be proved ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Experience and Lesson From Postpartum Ruptured Abdominal Aortic Aneurysm

et al. 2022

View full text Add to dashboard Cite

With rapid progression and extremely high mortality brought by the ruptured aneurysm, abdominal aortic aneurysm is one of the most dangerous diseases in the field of vascular surgery. The incidence of abdominal aortic aneurysms in pregnant women is low. Because of the insidious nature of the disease, it is not easily recognized and can be easily misdiagnosed by obstetricians, which can lead to serious adverse outcomes. In this study, we aim to draw attention to this disease and raise awareness among obstetricians about this disease in pregnant women by retrospectively analyzing a rescue case of ruptured abdominal aortic aneurysm after delivery. By reporting the experience and lessons learned from this case, we aim to improve preoperative diagnosis and treatment rates, reduce missed diagnosis, and improve the prognostic outcome of patients.

show abstract

“…To the best of our knowledge, only limited reports exist which discuss these symptoms in pregnancy. 11,12) Vascular lesions due to NF1-induced vascular fragility are diverse and include aneurysms, arteriovenous fistulas, and arterial rupture. Comorbidity rates of these vascular lesions in NF1 range from 1.0 to 3.6%.…”

Section: Discussionmentioning

confidence: 99%

“…13) Ascending aortic rupture occurred in a previous NF1-complicated pregnancy. 11) The following mechanisms have been proposed for vascular fragility in NF1: (1) the direct infiltration of a neurofibroma into vascular mesothelium tissue, (2) ischemia of the vessel wall caused by the compression of a feeding artery by a neurofibroma, and (3) thinning of the vascular mesothelium and rupture of the elastic plate due to the growth of spindle-shaped cells in the vascular endothelium. These mechanisms lead to the formation of vascular lesions, vascular failure, and the weakening of the vessel wall in NF1 patients.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy complicated by neurofibromatosis type 1 in a patient with a history of massive spontaneous hemothorax: a case report

Kitamoto

Narumi

Oda

et al. 2022

Hypertens Res Pregnancy

View full text Add to dashboard Cite

Background Neurofibromatosis type 1 is a disorder characterized by café-au-lait spots and neurofibromas. Recent studies have suggested that neurofibromatosis type 1 may induce vascular fragility. Limited information is currently available on vascular fragility in pregnancies complicated by neurofibromatosis type 1. Case The patient was a 40-year-old woman (gravida 3, para 1) with neurofibromatosis type 1. In her second pregnancy, blood pressure began to rise at 30 weeks of gestation. At 34 weeks of gestation, left intercostal artery rupture and massive hemothorax occurred, resulting in neonatal death. In her third pregnancy, caesarean section was performed at 30 weeks of gestation prior to the expected increase in blood pressure, resulting in a livebirth. However, the patient died three months later due to left intercostal artery rupture. Conclusion Pregnancy complicated by neurofibromatosis type 1 is associated with vascular fragility, leading to fatal events. Thus, obstetricians should be aware of this condition. A management strategy needs to be established for vascular fragility in complicated pregnancy.

show abstract

Spontaneous ascending aortic rupture in a pregnant woman with neurofibromatosis type 1

Cited by 5 publications

References 5 publications

Antepartum acute Stanford type A aortic dissection: a case report and literature review

Antepartum acute Stanford type A aortic dissection: a case report and literature review

Case Report: Experience and Lesson From Postpartum Ruptured Abdominal Aortic Aneurysm

Pregnancy complicated by neurofibromatosis type 1 in a patient with a history of massive spontaneous hemothorax: a case report

Contact Info

Product

Resources

About