Promoting Scientist–Advocate Collaborations in Cancer Research: Why and How

Salamone, Jeannine M.; Lucas, Wanda; Brundage, Shelley B.; Holloway, Jamie N.; Stahl, S; Carbine, Nora E; London, Margery; Greenwood, Naomi; Goyes, Rosa; Chisholm, Deborah Charles; Price, Erin; Carlin, Roberta; Winarsky, Susan; Baker, Kirsten B.; Maues, Julia; Shajahan-Haq, Ayesha N.

doi:10.1158/0008-5472.can-18-1600

Cited by 26 publications

(20 citation statements)

References 25 publications

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“…Reliable biomarkers have been the subject of many classic studies in cancer research (Salamone et al, 2018). Pan-cancer research can play a pivotal role in the development of diagnosis, treatment plans and novel therapeutics (Gizem et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

et al. 2020

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Glioblastoma (GBM) has long been a major clinical research challenge to scientists. The pivotal role of the mitochondria related gene family in the promotion of GBM tumorigenesis is not clear. We detected that microtubular tubulin beta 6 class V (TUBB6) was one of 33 differentially expressed mitochondrial-focused genes (DEMFGs) in GBM, and considered that TUBB6 is a potential therapeutic target in GBM. TUBB6 was vital for GBM and marked as the key prognostic gene in primary GBM. Mutations of TUBB6 in GBM were rare. Only four TUBB6 co-expressed hub genes (ANXA2, S100A11, FLNA, and MSN) exhibited poorer overall survival rates in higher expression groups (p-value < 0.05). We have confirmed the up-regulation of TUBB6 and its partners, ANXA2 and S100A11 in GBM and validated their importance as prognostic factors in primary GBM. TUBB6 was significantly correlated with stromal score in GBM samples (p-value = 6.99E-04). This study aimed to assess the importance of novel hub genes by analyzing the expression, potential function and prognostic impact of TUBB6 in human primary GBM cancer.

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Section: Introductionmentioning

confidence: 99%

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

et al. 2020

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Section: Discussionmentioning

confidence: 99%

“…25 Having patient advocates involved in discussions of cancer and cancer care provides unique viewpoints that allow us to ensure that our medical advances are relevant and patient centered. 26,27 The COVID-19 pandemic has pushed social media into center stage. It is being used for the dissemination of reliable information as it emerges, sharing practical experiences in real time and facilitating international collaborations to collect data.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network

Morgan¹,

Tagliamento²,

Lambertini³

et al. 2021

ESMO Open

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Background The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic. Materials and methods A 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network. Results One thousand and seventy-six physicians and stakeholders took part in the survey. In total, 57.3% of respondents were medical oncologists, 50.6% aged <40 years, 50.8% of female gender and mostly practicing in Europe (51.5%). More than 90% of respondents considered social media a useful tool for distributing scientific information and for education. Most used social media to stay up to date on cancer care in general (62.5%) and cancer care during COVID-19 (61%) given the constant flow of information. Respondents also used social media to interact with other oncologists (78.8%) and with patients (34.4%). Overall, 61.1% of respondents were satisfied with the role that social media was playing during the COVID-19 pandemic. On the other hand, 41.1% of respondents reported trouble in discriminating between credible and less credible information and 30% stated social networks were a source of stress. For this reason, one-third of respondents reduced its use during the COVID-19 pandemic. Regarding meeting attendance, a total of 59.1% of responding physicians preferred in-person meetings to virtual ones, and 51.8% agreed that virtual meetings and social distancing could hamper effective collaboration. Conclusion Social media has a useful role in supporting cancer care and professional engagement in oncology. Although one-third of respondents reported reduced use of social media due to stress during the COVID-19 pandemic, the majority found social media useful to keep up to date and were satisfied with the role social media was playing during the pandemic.

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“…Scientists and patient advocates increasingly work together in a mutual desire to advance cancer research (3)(4)(5)(6). Most visibly, patient advocates routinely serve with scientists on research review panels, typically assessing the potential impact of proposed research.…”

Section: Cancer Research and Patient Advocatesmentioning

confidence: 99%

Connecting Students with Patients and Survivors to Enhance Cancer Research Training

Riter

Weiss

2019

Cancer Research

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The professional training of cancer researchers in the basic sciences rarely involves interactions with patients. To provide nascent cancer scientists with an appreciation for and experience in interacting with the people most vested in their work, we created a program at Cornell University in which cancer researchers in training engage with the local patient community. Through this program, trainees gain a broader understanding of cancer, beyond the fundamental biology, and learn to effectively communicate scientific information to the public. We find that trainees and community members both benefit from interacting with one another and learning together about cancer using a common language.

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Promoting Scientist–Advocate Collaborations in Cancer Research: Why and How

Cited by 26 publications

References 25 publications

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma

Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network

Connecting Students with Patients and Survivors to Enhance Cancer Research Training

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