Which came first, the risk of migraine or the risk of asthma? A systematic review

Sayyah, Mehdi; Saki-Malehi, Amal; Javanmardi, Fatemeh; Forouzan, Arash; Shirbandi, Kiarash; Rahim, Fakher

doi:10.1016/j.pjnns.2018.07.004

Cited by 15 publications

(19 citation statements)

References 39 publications

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“…To our knowledge, our study is not the first meta-analysis to examine the association between asthma and migraine. The previous meta-analysis by Sayyah et al (15) indicated the bidirectional association between asthma and migraine. But they mistakenly considered headache the same as migraine and included studies both on headache and migraine in the metaanalysis, which may reduce the accuracy and validity of the outcome.…”

Section: Discussionmentioning

confidence: 98%

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

Kang¹,

Chen

Tung

et al. 2021

Front. Allergy

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Objectives: The purpose of this study was to determine the association between asthma and migraine and assess the risk for migraine in patients with asthma.Methods: We systematically searched the Cochrane Library, PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica dataBASE (EMBASE) databases from inception to September 26, 2021, for indexed observational studies that examined either the odds or risk of migraine in subjects with asthma. The qualities of the included studies were evaluated using the Newcastle–Ottawa Scale. A random-effects meta-analysis was performed to calculate the odds ratio for case-control and cross-sectional studies and the risk ratio for cohort studies.Results: Seven observational studies (four cross-sectional and three cohort studies) with a total of 549,534 study subjects were included in this systematic review and meta-analysis and selected for data extraction. Four articles were considered to be of moderate quality; other studies were considered to be of high quality. Asthma was associated with increased odds (OR, 1.85; 95%CI, 1.39–2.45) and risk of migraine (RR, 1.70; 95%CI, 1.52–1.90).Conclusions: The available evidence that supports the existence of an association between asthma and migraine is limited. Clinicians should be aware that patients with asthma show both increased prevalence and incidence of migraine. Further studies are warranted to further clarify the relationship between asthma and migraine.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=185881, identifier: CRD42020185881.

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Section: Discussionmentioning

confidence: 98%

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

Kang¹,

Chen

Tung

et al. 2021

Front. Allergy

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“…We found that migraine was associated with 54% increased prevalence and 42% greater risk of asthma, and vice versa, asthma associated with 45% increased prevalence and 47% greater risk of migraine. One previous review investigated the relationship between migraine and asthma with only two cohort studies and six casecontrol/cross-sectional studies, and respective risks of developing migraine or asthma were not analyzed based on the findings (36). By contrast, in the current analysis, we included and added more recent studies including three cohort studies, two case-control/cross-sectional studies, and two populationbased studies that were left out, then separately analyzed data depending on the type of study design, thus providing robust evidence on the bidirectional association between migraine and asthma.…”

Section: Discussionmentioning

confidence: 99%

The Comorbid Relationship Between Migraine and Asthma: A Systematic Review and Meta-Analysis of Population-Based Studies

Wang

Deng

et al. 2021

Front. Med.

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Objective: Recent studies have indicated a pathophysiologic link between migraine and asthma. This meta-analysis aimed to comprehensively estimate the risk ratio for migraine in asthma as well as that of asthma in migraine based on available evidence.Method: We systematically searched the electronic databases including PubMed, Web of Science, and SCOPUS for population-based studies that measured either the odds or the risk of asthma in subjects with migraine as well as that of migraine in subjects with asthma. The titles and abstracts were screened by two independent reviewers to identify eligible studies, and this was followed by full-text review of the included studies. Newcastle–Ottawa Scale (NOS) was used to assess the risk of bias of included literature. A meta-analysis was conducted with Review Manager 5.3 Software to calculate the odds ratio (OR) for case-control and cross-sectional studies and either relative ratio (RR) or hazard ratio (HR) for cohort studies, and the source of heterogeneity was assessed. Subgroup and sensitivity analyses were conducted, and the I2 test were used to assess the source of heterogeneity. The funnel plot, Galbraith plot, and Egger's test were used to evaluate publication bias.Results: Fifteen published studies covering a total of 1,188,780 individuals were identified. Pooled analysis indicated that migraine was associated with increased odds (OR = 1.54; 95% CI: 1.34~1.77) and risk for asthma (HR = 1.42; 95% CI: 1.26~1.60), and asthma associated with increased odds (OR = 1.45; 95% CI: 1.22~1.72) and risk for migraine (HR = 1.47; 95% CI: 1.41~1.52).Conclusion: Migraine is a potential risk indicator for asthma, and vice versa, asthma is a potential risk indicator for migraine. However, future prospective cohort studies are warranted to provide more evidence concerning the detailed association between migraine and asthma.

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“…In line with the present results, several previous studies have reported an association between asthma and migraine. A recent meta-analysis reported that asthmatic patients had 1.62 times higher odds of migraines than control subjects (95% confidence interval [95% CI] = 1.43–1.82) 21 . However, the migraine patients showed a 1.56 times higher risk of asthma than the control subjects (95% CI = 1.51–1.60, P < 0.00001) 21 .…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis reported that asthmatic patients had 1.62 times higher odds of migraines than control subjects (95% confidence interval [95% CI] = 1.43–1.82) 21 . However, the migraine patients showed a 1.56 times higher risk of asthma than the control subjects (95% CI = 1.51–1.60, P < 0.00001) 21 . Using national health insurance data, a Taiwanese group demonstrated a 1.37-fold increased risk of asthma in migraine patients (95% CI = 1.21–1.56) 17 .…”

Section: Discussionmentioning

confidence: 99%

Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

Kim

Min

et al. 2019

Sci Rep

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the objective of this study was to evaluate the bidirectional association between asthma and migraines using control subjects matched by demographic factors. the Korean Health insurance Review and Assessment Service-National Sample Cohort from 2002 to 2013 was used. In study I, 113,059 asthma participants were matched with 113,059 control I participants. In study II, 36,044 migraine participants were matched with 114,176 control II participants. The hazard ratios (HRs) of migraines in the asthma patients (study I) and asthma in the migraine patients (study II) were analyzed using stratified Cox proportional hazard models after adjusting for depression and the Charlson comorbidity index. In study I, 5.3% (6,017/ 113,059) of the asthma group and 3.4% (3,806/ 113,059) of the control I group had migraines (P < 0.001). The asthma group demonstrated an adjusted HR of 1.47 for migraine (95% confidence interval (CI) = 1.41-1.53, P < 0.001). In study II, 15.4% (5,548/36,044) of the migraine group and 10.6% (15,271/144,176) of the control group had asthma (P < 0.001). The migraine group showed an adjusted HR of 1.37 for asthma (95% CI = 1.33-1.41, P value < 0.001). Asthma and migraines are reciprocally associated. Asthma is a chronic airway disease associated with clusters of respiratory symptoms, including wheezing and dyspnea. Asthma is a common disease with different prevalences according to ethnicity that range from approximately 7% to 18.0% 1. The incidence of asthma in the adult population (>20 years old) was estimated to be approximately 3.63-6.07 per 1,000 people in Korea 2. Because the diagnosis of asthma is based on the functional deterioration of the lower airway, the underlying pathophysiologic causes of asthma have been reported to vary among asthmatic patients 3. According to the pathophysiologic mechanisms, asthma is classified as two major endotypes of T-helper type 2 cell (TH2)-high and TH2-low diseases 4. Thus, in addition to TH2-high related diseases, such as allergic rhinitis, other immune-related diseases could complicate asthma. In addition, both genetic factors and environmental triggering factors have been suggested to be related to asthma 5,6. Migraine disorder is another chronic disease characterized by multiple symptoms of headache and/or aura. As many as approximately 1.04 billion people suffer from migraines worldwide (95% uncertainty interval = 1.00-1.09) 7. In Korea, approximately 6.0% of the adult population (19-69 years) suffers from migraines 8. Migraines are characterized by recurrent episodic symptom sequences of a premonitory phase, an aura phase, a headache phase, and a postdrome phase 9. The environmental triggering factors can hyper-activate the hypothalamic-pituitary-adrenocortical axis and autonomic nervous system in migraine susceptible subjects 10. These hormonal and nervous changes induce vasodilation, the release of vascular factors, including growth factors, cytokines, nitric oxide, norepinephrine and calcitonin gene-related peptide, and interaction with endothelial cells, res...

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Which came first, the risk of migraine or the risk of asthma? A systematic review

Cited by 15 publications

References 39 publications

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

The Comorbid Relationship Between Migraine and Asthma: A Systematic Review and Meta-Analysis of Population-Based Studies

Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

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