ALA-PDT promotes HPV-positive cervical cancer cells apoptosis and DCs maturation via miR-34a regulated HMGB1 exosomes secretion

Jin, Yue; Guan, Zhen; Wang, Xiaochuan; Wang, Zhiqiong; Zeng, Rong; Xu, Liangheng; Cao, Ping

doi:10.1016/j.pdpdt.2018.08.006

Cited by 24 publications

(19 citation statements)

References 30 publications

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“…A correlation between alterations of heme and miRNAs expression was also reported. For instance, ALA-mediated sonodynamic therapy or PDT is associated with the altered expression of selected miRNAs (158)(159)(160)(161). Although, further studies are required to fully understand the physio-pathological implications of these findings, these data suggest that mysregulation of miRNAs may represent an additional mechanism through which alterations of heme metabolism sustain and promote cancer progression.…”

Section: Additional Heme Functions Potentially Relevant For Cancermentioning

confidence: 99%

The Multifaceted Role of Heme in Cancer

et al. 2020

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Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in several biological processes, including oxygen transport, energy production and drug metabolism. Besides these vital functions, heme also bears toxic properties and, therefore, the amount of heme inside the cells must be tightly regulated. Similarly, heme intake from dietary sources is strictly controlled to meet body requirements. The multifaceted nature of heme renders it a best candidate molecule exploited/controlled by tumor cells in order to modulate their energetic metabolism, to interact with the microenvironment and to sustain proliferation and survival. The present review summarizes the literature on heme and cancer, emphasizing the importance to consider heme as a prominent player in different aspects of tumor onset and progression.

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Section: Additional Heme Functions Potentially Relevant For Cancermentioning

confidence: 99%

The Multifaceted Role of Heme in Cancer

et al. 2020

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“…Additionally, TIM-1 + Breg cells in contact with CD8 + T lymphocytes induce suppression, decrease proliferation and TNF-α and IFN-α expression. TIM-1 + Breg are excellent producers of IL-10, presenting a correlation with increased recurrence, decrease of overall survival and disease-free survival of hepatocellular carcinoma patients (143), which together are associated with a poor prognosis.On the other hand, treatment of cervical cancer cell lines with 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) can increase HMGB1 content in tumor-derived Exo, which was found to be beneficial to the activation of APCs, inducing secretion of IL-6, IL-12, IL-18, IFN-γ, and TNF-α in vitro (144).…”

Section: Hmgb1 and Cancermentioning

confidence: 99%

Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1

et al. 2019

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Although much has been made of the role of HMGB1 acting as an acute damage associated molecular pattern (DAMP) molecule, prompting the response to tissue damage or injury, it is also released at sites of chronic inflammation including sites of infection, autoimmunity, and cancer. As such, the biology is distinguished from homeostasis and acute inflammation by the recruitment and persistence of myeloid derived suppressor cells, T regulatory cells, fibrosis and/or exuberant angiogenesis depending on the antecedents and the other individual inflammatory partners that HMGB1 binds and focuses, including IL-1β, CXCL12/SDF1, LPS, DNA, RNA, and sRAGE. High levels of HMGB1 released into the extracellular milieu and its persistence in the microenvironment can contribute to the pathogenesis of many if not all autoimmune disorders and is a key factor that drives inflammation further and worsens symptoms. HMGB1 is also pivotal in the maintenance of chronic inflammation and a “wound healing” type of immune response that ultimately contributes to the onset of carcinogenesis and tumor progression. Exosomes carrying HMGB1 and other instructive molecules are released and shape the response of various cells in the chronic inflammatory environment. Understanding the defining roles of REDOX, DAMPs and PAMPs, and the host response in chronic inflammation requires an alternative means for positing HMGB1's central role in limiting and focusing inflammation, distinguishing chronic from acute inflammation.

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“…With the high mortality rate of cervical cancers, more information is needed regarding detection and treatment of the diseased. In this regard, several investigators have begun to examine extracellular vesicles (EVs) and their role in disease protection [2], as disease biomarkers [3][4][5] and/or as a cargo/vaccine agents for cervical cancer [6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Exposure Impacts the Composition of HeLa-Derived Extracellular Vesicles

et al. 2019

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Extracellular vesicles are nanosized vesicles that are under intense investigation for their role in intercellular communication. Extracellular vesicles have begun to be examined for their role in disease protection and their role as disease biomarkers and/or vaccine agents. The goal of this study was to investigate the effects of alcohol exposure on the biogenesis and composition of extracellular vesicles derived from the cervical cancer line, HeLa. The HeLa cells were cultured in exosome-free media and were either mock-treated (control) or treated with 50 mM or 100 mM of alcohol for 24 h and 48 h. Our results demonstrated that alcohol significantly impacts HeLa cell viability and exosome biogenesis/composition. Importantly, our studies demonstrate the critical role of alcohol on HeLa cells, as well as HeLa-derived extracellular vesicle biogenesis and composition. Specifically, these results indicate that alcohol alters extracellular vesicles’ packaging of heat shock proteins and apoptotic proteins. Extracellular vesicles serve as communicators for HeLa cells, as well as biomarkers for the initiation and progression of disease.

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ALA-PDT promotes HPV-positive cervical cancer cells apoptosis and DCs maturation via miR-34a regulated HMGB1 exosomes secretion

Cited by 24 publications

References 30 publications

The Multifaceted Role of Heme in Cancer

The Multifaceted Role of Heme in Cancer

Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1

Alcohol Exposure Impacts the Composition of HeLa-Derived Extracellular Vesicles

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