Abstract:Colostrum and milk are the initial mammalian nourishment and rich reservoir of essential nutrients for newborn development. Bioactive peptides isolated from natural sources, such as colostrum, serve as endogenous regulators and can be used as alternative therapeutic agents in the treatment of neurodegenerative diseases. One example is the previously unknown NP-POL nonapeptide isolated from Colostrinin. In the present study, we investigated a method of NP-POL nonapeptide isolation using Bio-Gel P2 molecular sie… Show more
“…Previous studies have demonstrated that 6-OHDA induce neurotoxicity in PC12 cells to construct a cellular model of PD. [22][23][24][25] Firstly, the cytotoxic effect of 6-OHDA on PC12 cells were measured via a CCK8 assay. PC12 cells were treated with different doses of 6-OHDA (50, 100, 150, and 200 mM) for 24 h; at concentrations of over 50 mM the viability of PC12 cells was significantly affected, and a concentration of 100 mM or higher did not decrease the cell viability (Fig.…”
Section: Sal Alleviated 6-ohda-induced Injury In Pc12 Cellsmentioning
Parkinson's disease (PD) is the second-most common neurodegenerative disease characterized by oxidative stress (OS) in the development and progression of PD. This study determined the neuroprotective effects of Salidroside (Sal)....
“…Previous studies have demonstrated that 6-OHDA induce neurotoxicity in PC12 cells to construct a cellular model of PD. [22][23][24][25] Firstly, the cytotoxic effect of 6-OHDA on PC12 cells were measured via a CCK8 assay. PC12 cells were treated with different doses of 6-OHDA (50, 100, 150, and 200 mM) for 24 h; at concentrations of over 50 mM the viability of PC12 cells was significantly affected, and a concentration of 100 mM or higher did not decrease the cell viability (Fig.…”
Section: Sal Alleviated 6-ohda-induced Injury In Pc12 Cellsmentioning
Parkinson's disease (PD) is the second-most common neurodegenerative disease characterized by oxidative stress (OS) in the development and progression of PD. This study determined the neuroprotective effects of Salidroside (Sal)....
“…43 Another study demonstrated that the active ingredient in colostrinin reduced rather than induced the neurotoxicity of adrenal pheochromocytoma cells that was induced by 6-hydroxydopamine, via transient activation of the ERK pathway. 44 Lactoferrin protects the neuronal cell by stabilizing the hypoxiainducible factor-1α via its up-regulatory effects on the prolyl hydroxylase enzyme and thereby prevents the formation of the abnormal isoform prion protein. 45 Other researchers demonstrated that insulin growth factor-1, which is available in the BC, plays an important role in the suppression of neurodegeneration via its effect on the generation of reactive oxygen species and improves mitochondrial function by blocking the effect of the cellular prion protein upon the mitochondria.…”
Section: Counteract Inflammation That Is Implicated In the Deteriorat...mentioning
Bovine colostrum (BC) is rich in many vitamins, minerals, and antioxidant substances. Its supplementation provides health benefits, particularly for athletes. This systematic review was carried out to update on the benefit of BC or its formulations (e.g., colostrinin) on the cognitive functions or their related biomarkers in experimental and human studies. Full texts or abstracts of 219 articles as reports of narrative or systematic reviews, randomized controlled clinical trials, observational studies, and experimental studies (in vitro, ex vivo, and in vivo) were included after searches in PubMed, Europe PMC, Google scholar databases. The full texts of eligible articles (25 articles) were assessed and their results were summarized in different categories according to the study design. Bovine colostrum or its related formulations have been shown to be useful as they improve cognitive functions and their biomarkers. Compatible results were observed in experimental and human studies. Further studies are mandatory to elucidate the rationale for using (BC) in healthy subjects and patients with impaired of cognitive functions.
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