Cervical Adenoid Basal Carcinoma: Clinicopathologic Features of 9 Cases With Reference to CK17 and Ki-67 Expression

Liang, Yun; Lü, Bingjian; Zhou, Caiyun

doi:10.1097/lgt.0000000000000428

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Ferry et al reported a distinct age distribution among patients with ACC and ABC, and most cases occurred in Western countries (19). Early reports indicated that the median age of postmenopausal black women with cervical ACC and ABC was mainly between the 60s and 70s (range, 50-86 years) (12,17,18,21). Consistent with previous findings, the data of our study demonstrated that the median age of cervical ACC and ABC patients was 70 years (range, 62-78 years).…”

Section: Analysis For Radiotherapy or Chemotherapy Patientsmentioning

confidence: 99%

The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix

et al. 2022

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Background: Cervical adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are rare cervical cancer types and have unclarified clinicopathological features and survival outcomes. This retrospective study focused on predicting the value of radiotherapy or/and chemotherapy for cervical ACC and ABC patients. Methods: The clinical data of cervical ACC and ABC patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 and 2013 were included. The clinicopathological features, Kaplan-Meier curves, and overall survival (OS) of patients were evaluated. The prognostic nomogram was established based on the multivariate Cox models. To validate the nomogram prediction, Harrell's Concordance index (C-index) was calculated and receiver operating characteristic (ROC) curves were generated.Results: A total of 84 cervical ACC and 82 ABC patients were identified, and ABC patients had better 10-year OS than ACC patients (60.81% vs. 36.94%, P=0.001). Age, ACC, surgery, radiotherapy, chemotherapy, and regional node involvement were significantly correlated with patient prognosis. In the multivariate analysis, only age >80 years (HR =5.945, 95% CI: 1.912-18.485, P=0.002) and age 70-80 years (HR =4.803, 95% CI: 1.626-14.188, P=0.005) were independent predictors of patient prognosis. In subgroup analysis, patients who underwent surgery (HR =2.199, 95% CI: 1.085-4.455, P=0.029) and the ABC subgroup (HR =4.233, 95% CI: 1.532-11.696, P=0.005) received radiotherapy, chemotherapy, or chemoradiotherapy with a poor prognosis. Patients received radiotherapy (HR =1.936, 95% CI: 1.208-3.105, P=0.006) was associated with a poor prognosis, while surgical patients had a better prognosis (HR =0.535, 95% CI: 0.344-0.832, P=0.006).Conclusions: Cervical ABC patients had a better survival time than cervical ACC patients. We found that increased age was potentially an independent risk factor for poor prognosis, surgical patients had a better prognosis, and radiotherapy, or chemotherapy combination treatment had an unfavorable tendency to prognosis.

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Section: Analysis For Radiotherapy or Chemotherapy Patientsmentioning

confidence: 99%

The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix

et al. 2022

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“…CABCC was rst reported in 1966 and primarily occurs in postmenopausal women accompanied with other pathological type of cervical carcinoma. The levels of carbohydrate antigen 125, squamous cell carcinoma antigen and carbohydrate antigen 199 in serum are mostly within the normal range (3). For individuals who develop this disease, they may experience abnormal vaginal bleeding or contact bleeding, and the cervix may exhibit an obvious mass as it is basically accompanied by other types of cancer (4).…”

Section: Introductionmentioning

confidence: 99%

A friendly pathological type of cervical carcinoma: Pure Cervical Adenoid Basal Cell Carcinoma: An asymptomatic case report and literature review

Li,

Su,

Huang

et al. 2023

Preprint

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Background: Cervical adenoid basal cell carcinoma (CABCC) is a rare pathological type of cervical cancer. According to the statistics of the World Health Organization (WHO), CABCC accounts for less than 1% of all cervical carcinomas. Since the clinical symptoms of patients with pure CABCC are not typical unless there are other types of cervical cancer present, early diagnosis and treatment are of great importance. Case Presentation: This report presents a case of pure cervical adenoid basal cell carcinoma without typical symptoms at the Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The intention is to analyze its clinical features, morphology, and pathology, aiming to provide insights for a better understanding of the disease. Discussion and Conclusion: Pure CABCC is a rare type of cervical cancer with a relatively favorable prognosis. However, regular cervical cancer screening remains highly significance for early detection and treatment.

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Epithelial Malignant Tumors of the Cervix: Other Epithelial Tumors (Adenosquamous Carcinoma, Adenoid Basal Carcinoma, Carcinoma with Adenoid Cystic-like Features, Undifferentiated Carcinoma)

Hodgson

2020

Atlas of Diagnostic Pathology of the Cervix

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Cervical Adenoid Basal Carcinoma: Clinicopathologic Features of 9 Cases With Reference to CK17 and Ki-67 Expression

Cited by 6 publications

References 15 publications

The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix

The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix

A friendly pathological type of cervical carcinoma: Pure Cervical Adenoid Basal Cell Carcinoma: An asymptomatic case report and literature review

Epithelial Malignant Tumors of the Cervix: Other Epithelial Tumors (Adenosquamous Carcinoma, Adenoid Basal Carcinoma, Carcinoma with Adenoid Cystic-like Features, Undifferentiated Carcinoma)

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