Design, synthesis, and activity evaluation of novel erythropoietin mimetic peptides

Feng, Siliang; Chang, Shaohua; Yan, Ling-di; Dong, Honglin; Xu, Xiaoyu; Wang, Chenhong; Liang, Yuanjun; Liu, Keliang

doi:10.1016/j.bmcl.2018.08.004

Bioorganic & Medicinal Chemistry Letters

2018

DOI: 10.1016/j.bmcl.2018.08.004

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Design, synthesis, and activity evaluation of novel erythropoietin mimetic peptides

Siliang Feng¹,

Shaohua Chang²,

Ling-di Yan³

et al.

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2021

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“…Erythropoietin synthesis rises when there is blood oxygen fall (hypoxic stimulus). Erythrocyte amount increase leads to oxygen growth and erythropoietin reduction [71,72]. RBC division and maturation also depend on vitamins B to B 12 and folic acid [73].…”

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Oxidative stress as a factor in the deterioration of oxygen transfer during exercise

Gunina¹,

Rybina²,

Ataman³

et al. 2021

Fiziol Zh

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Blood oxygen transport regulation by physical activity increase within training dynamics is provided with different mechanisms: from the quantitative and qualitative erythron restructure (including endogenous erythropoietin rise and main erythrocyte index shifts) to change in haemoglobin affinity to oxygen, its heterogeneous structure and blood flow growth as a result of endothelium hyperpolarisation. However, the erythrocyte itself remains a key performer in blood velocity control, due to its structure and functions. This review summarizes the data of modern scientific literature on the characteristics of erythrocytes, which make these cells one of the key links in the oxygen transport system of the blood. The focus on this property of erythrocytes during physical activity is based on the fact that the athlete’s muscles must be supplied with enough oxygen to ensure high performance. Specific training and extra-training factors affecting the content of erythrocytes have been determined. The membrane structure is treated as a significant erythrocyte part in determining its deformation and microvascular blood transport. Enzymes associated with the erythrocyte membrane and affecting cell viability and performance are described. Besides, it is stressed on monitoring erythrocyte indices via modern equipment and assessing lipid peroxidation, which leads to disorders in erythrocyte membrane structure and functions.

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mentioning

confidence: 99%

Oxidative stress as a factor in the deterioration of oxygen transfer during exercise

Gunina¹,

Rybina²,

Ataman³

et al. 2021

Fiziol Zh

View full text Add to dashboard Cite

show abstract

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Design, synthesis, and activity evaluation of novel erythropoietin mimetic peptides

Cited by 1 publication

References 23 publications

Oxidative stress as a factor in the deterioration of oxygen transfer during exercise

Oxidative stress as a factor in the deterioration of oxygen transfer during exercise

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