B lymphocyte–induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation

Benevides, Luciana; Sesti-Costa, Renata; Tavares, Lucas Alves; Russo, Marco; Martins, Gislâine A.; Silva, Luis Lamberti P. da; Arruda, L. Karla; Cunha, Fernando; Carregaro, Vanessa; Silva, João

doi:10.1016/j.jaci.2018.06.046

Cited by 21 publications

(11 citation statements)

References 44 publications

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“…Th2 cells express the transcriptional factors PU.1 and interferon regulatory factor (IRF) 4 in the presence of IL-4 and TGF- β , thus driving Th9 cell activation via the STAT6 signal [ 42 – 44 ]. Reversely, Th9 cells are suppressed by the overexpression of B lymphocyte-induced maturation protein 1 (Blimp-1) [ 45 ]. Th9 cells produce IL-9 to recruit and activate mast cells and B cells, associated with IgE elevation and corticosteroid resistance [ 46 , 47 ].…”

Section: Imbalance Of T Cells In Asthma Pathogenesismentioning

confidence: 99%

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Zhu

Cui

Liu

et al. 2020

Mediators of Inflammation

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Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.

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Section: Imbalance Of T Cells In Asthma Pathogenesismentioning

confidence: 99%

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Zhu

Cui

Liu

et al. 2020

Mediators of Inflammation

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“…Moreover, allergen-specific induction of IL-9 in PBMCs of atopic patients and in animal models has been reported [41]. H. contortus ESPs play crucial roles in parasite virulence as well as host-parasite interactions, mainly through the modulation of the host immune response [21,41]. In this study, the modulatory effects of ESPs on goat PBMCsderived Th9 cells production and immune response in vitro and during different stages of H. contortus infection in goat were evaluated.…”

Section: Discussionmentioning

confidence: 96%

“…Th9 cells in human diseases were known to contribute in both protective immune responses and pathological responses leading to immunemediated pathology [7]. Moreover, allergen-specific induction of IL-9 in PBMCs of atopic patients and in animal models has been reported [41]. H. contortus ESPs play crucial roles in parasite virulence as well as host-parasite interactions, mainly through the modulation of the host immune response [21,41].…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat

et al. 2020

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CD4+ T cells play critical roles in mediating adaptive immunity to a variety of pathogens. Recently, new subset of CD4+T named as T helper 9 cells that express the prototypical interleukin-9 (IL-9) cytokine have been recognized in human and mice models during different parasitic infections. Haemonchus contortus is a gastrointestinal nematode of small ruminants which cause high mortality in young animals. During infection, Excretory and Secretary Products (ESPs) are released in the host body. No other study has reported yet on immunomodulatory dynamics of H. contortus ESPs on Th9 immune response in vitro or in vivo. In this study, immunomodulatory effects of ESPs (5, 10, 20, 40, 80; μg/mL) incubated with goat PBMCs on Th9 cells, IL-9 immune response and TGF-β/Smad signaling regulator were evaluated in vitro. Moreover, for in vivo study, goats were infected with different doses (P-800, P-2400, and P-8000) of H. contortus infective larva (L3) and immunomodulatory effects on Th9 cells, IL-9 immune response and TGF-β/Smad signaling regulator were evaluated at 7, 10, 14, 18, 21, 28 Days Post Infection (DPI). Flow cytometry was performed to evaluate the effects on Th9 cells and quantitative real time polymerase chain reaction was performed to evaluate the IL-9 cytokine transcription level. Additionally, fecal egg counting was also performed in parallel to confirm the infection. All goats were dewormed at 29 DPI and all experiments were also performed at 35 DPI, one week post deworming. The finding indicated that 10, 20, 40, 80 μg/mL concentration of ESPs incubated with goat PBMCs showed significant increase in the production of Th9 cells, signature cytokine IL-9 and expression of TGF-β/Smad signaling regulator as compared to control group in vitro.All infected groups showed significant increase in production of Th9 cells and IL-9 cytokine and expression of TGF-β/Smad key genes at 18, 21, and 28 DPI as compared to control group. Likewise, at 14 DPI, P-2400 and P-8000 groups showed significant increase in production of Th9 cells, IL-9 cytokine and expression of TGF-β/Smad key genes. While at 10 DPI, production of Th9 cells and IL-9 was significantly

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“…Interestingly, most recent evidence has shown that Blimp-1 can repress the Th9 differentiation program and IL-9 production. Moreover, the inhibition of Blimp-1 by other cytokines related to Th9 cell differentiation is essential for high IL-9 production of Th9 cells (Benevides et al , 2019), which indicates that there are some negative regulators of Th9 programming, even though the exact mechanism remains to be elucidated.…”

Section: Transcription Factors Related To the Differentiation Of Th9 mentioning

confidence: 99%

T Helper 9 Cells: A New Player in Immune-Related Diseases

Chen

Guan

Tang

et al. 2019

DNA and Cell Biology

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The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4 + T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor b, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immunerelated diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect.

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B lymphocyte–induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation

Abstract: Blimp-1 is a pivotal negative regulator of T9 differentiation and controls allergic inflammation.

Cited by 21 publications

References 44 publications

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat

T Helper 9 Cells: A New Player in Immune-Related Diseases

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