“…The analysis of the bioenergetic properties of human mural luteinized GCs and CCs presented have allowed the progress in the understanding of the metabolism of these two follicular cell types that are known to influence the maturation of the oocyte and, ultimately, IVF outcomes (Shufaro et al, 2012;Liu et al, 2017). These cells are believed to be potential biomarkers of oocyte quality (Dumesic et al, 2015;Anderson et al, 2018), and it has been proposed that alterations in their energy metabolism could lead to infertility (Shufaro et al, 2012;Hsu et al, 2014;Dong et al, 2016;Liu et al, 2017). The results evidence (i) the high glycolytic profile of these two cell types, (ii) that the respiratory capacity relies on the presence of follicular fluid in the experimental media, and (iii) that luteinized GCs from aged women present lower respiration and aerobic glycolysis which lead to a decrease in the cellular ATP levels.…”