Lactobacilli can attenuate inflammation in mouse macrophages exposed to polyethylene particles in vitro

Esvaran, Meera; Conway, Patricia L.

doi:10.1186/s13104-018-3676-z

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…shown to suppress LPS-induced NF-κB activation leading to decrease secretion of proinflammatory cytokines in human myometrial cells as well as suppressed polyethylene-induced NF-κB in RAW 246.7 macrophages (Esvaran & Conway, 2018;Kim, Shynlova, & Lye, 2019).…”

Section: Discussionmentioning

confidence: 98%

Mechanism of immune modulation in macrophages by Enterococcus faecalis

Tien¹

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It still seems rather unbelievable that the time has come for me to write this section. This work is an accumulation of help and support that I have received throughout my graduate studies, without which it would not have been possible to complete. First and foremost, I would like to express my heartfelt gratitude and appreciation towards my supervisor, Associate Prof Kimberly Kline. Thank you for always being the kind, supportive, encouraging supervisor, never doubting me and giving me the freedom to develop my own research. Without your unwavering support and guidance, I would have never grown to become the scientist I am today.I am also thankful to my co-supervisor, Associate Prof Kevin Pethe, and my mentor, Professor Christiane Ruedl for their guidance, supervision and suggestions which help in pushing this project forward. This journey would not have been possible without all the support and help that I received from people of SCELSE, both past and present. Thank you to my mini mentor Dr Kelvin Chong for all the advice, help and encouragement that you have given me and for always being there when I need a listening ear. I would not have come this far without your help. I am also thankful to Dr Tay Wei Hong, for all the scientific and nonscientific advices that you have given me whenever necessary. Life in Kline lab is really different without the two of you around. I am also grateful to

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Section: Discussionmentioning

confidence: 98%

Mechanism of immune modulation in macrophages by Enterococcus faecalis

Tien¹

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Combination treatment with whole body vibration and simvastatin improves the early osseointegration in aged rats

Qiao,

Gu,

Wang

et al. 2024

Bone Reports

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Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling

Wang,

Cen

et al. 2024

IJN

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Introduction Overactive bladder (OAB) is a highly prevalent condition with limited treatment options due to poor efficacy, side effects, and patient compliance. Novel drug delivery systems that can target the bladder wall may improve OAB therapy. Methods We explored a polydopamine (PDA)-coated lactobacillus platform as a potential carrier for localized OAB treatment. Urinary microbiome profiling was performed to identify the presence of lactobacillus in healthy and OAB groups. Lactobacillus-PDA nanoparticles were synthesized and characterized by electron microscopy and spectrophotometry. A rat bladder perfusion model and human bladder smooth muscle cell spheroids were used to assess the distribution and penetration of the nanoparticles. The efficacy of the Lactobacillus-PDA system (LPS) for delivering the antimuscarinic drug solifenacin was evaluated in an OAB rat model. Results Urinary microbiome profiling revealed lactobacillus as a dominant genus in both healthy and OAB groups. The synthesized Lactobacillus-PDA nanoparticles exhibited uniform size and optical properties. In the rat bladder perfusion model, the nanoparticles distributed throughout the bladder wall and smooth muscle without toxicity. The nanoparticles also penetrated human bladder smooth muscle cell spheroids. In the OAB rat model, LPS facilitated the delivery of solifenacin and improved treatment efficacy. Discussion The results highlight LPS as a promising drug carrier for targeted OAB therapy via penetration into bladder tissues. This bacteriotherapy approach may overcome limitations of current systemic OAB medications. Lactobacillus, a probiotic bacterium present in the urinary tract microbiome, was hypothesized to adhere to and penetrate the bladder wall when coated with PDA nanoparticles, making it a suitable candidate for localized drug delivery.

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Lactobacilli can attenuate inflammation in mouse macrophages exposed to polyethylene particles in vitro

Cited by 3 publications

References 17 publications

Mechanism of immune modulation in macrophages by Enterococcus faecalis

Mechanism of immune modulation in macrophages by Enterococcus faecalis

Combination treatment with whole body vibration and simvastatin improves the early osseointegration in aged rats

Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling

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