BK Virus Characterisation among HIV-1-Infected Individuals and Its Association with Immunosuppression

Jagannath, Subha; Sachithanandham, Jaiprasath; Ramalingam, Veena Vadhini; Demosthenes, John Paul; Abraham, Asha Mary; Zachariah, Anand; Varghese, George M.; Kannangai, Rajesh

doi:10.4103/ijmm.ijmm_18_54

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Тем не менее, BKPyV признан причиной заболевания почек у пациентов с иммунодефицитом, вызванным СПИДом, и у пациентов, проходящих лечение злокачественных новообразований [4]. В исследовании S. Jagannath et al ( 2018) частота BKPyV-урии была значительно выше у ВИЧ-1положительных (25,6%), чем у ВИЧ-отрицательных (10,7%) [56]. Также исследование показало, что средняя вирусная нагрузка выше среди ВИЧ-1положительных, чем у ВИЧ-отрицательных людей, и существует значительная корреляция между степенью иммуносупрессии и BKPyV-урией [29,56].…”

Section: особенности течения заболевания при вичположительном статусеunclassified

A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

Prilepskaya

Домонова

2023

jour

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Reactivation of Betapolyomavirus hominis (BKPyV) in kidney and hematopoietic stem cell recipients can lead to serious complications such as BKPyV-associated nephropathy followed by transplant rejection and BKPyV-associated hemorrhagic cystitis. Early diagnosis of the disease is hampering by the possible combination of infection of BKPyV with other post-transplant pathologies and the absence of specific symptoms. Replication of BKPyV is currently the only reliable prognostic sign of the development of long-term consequences, so patient management is basseting on monitoring the concentration of viral DNA. However, consistency between the results of determining the viral load and the development of post-transplant complications associated with BKPyV reactivation cannot be achieving without effective means of standardizing laboratory testing. This review covers the current understanding of the epidemiology; pathogenesis and the clinical features of the disease associated with BKPyV, and also considers in detail the current methods of laboratory diagnosis infection of BKPyV.

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Section: особенности течения заболевания при вичположительном статусеunclassified

A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

Prilepskaya

Домонова

2023

jour

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“…A cycling time of less than 37 was considered positive. [ 11 ] Hence, any positive qualitative BKPyV PCR in urine with cystitis symptoms or evidence of HC was regarded as a BKPyV-HC case. Subsequently, we standardized a quantitative PCR using plasmids (based on the earlier qualitative PCR), for which a standard curve is generated for every run of the quantitative assay.…”

Section: Ethodsmentioning

confidence: 99%

BK polyomavirus hemorrhagic cystitis in hematopoietic cell transplant recipients

Lionel

Abraham

Lakshmi

et al. 2022

J Global Infect Dis

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Introduction: BK polyomavirus-associated hemorrhagic cystitis (BKPyV-HC) is a well-recognized infective complication of hematopoietic cell transplant (HCT) with increased organ dysfunction and mortality. This study was performed to describe the local incidence, risk factors, and outcomes of BKPyV infection. Methods: This retrospective case–control study was conducted between 2007 and 2016 from a tertiary hospital in South India. We identified HCT recipients diagnosed with BKPyV-HC and compared them with recipients over the same period who did not develop BK virus infection matched for age, sex, diagnosis, and donor type. We collected data from central electronic medical records and databases maintained in the departments of hematology and virology. Results: Over the study period, 1276 transplants were performed, of which 262 patients (20.5%) developed HC and 105 (8.2%) were BKPyV-positive. Grade 3 HC was most commonly (57.1%) seen, and the median time to develop BKPyV-HC was 35 (range 0–858) days. Survival was significantly lower in the cases (42.9% vs. 61%, P < 0.05). On univariate analysis, the protective effect of nonmyeloablative conditioning ( P = 0.04), residual disease at the time of transplant in malignant conditions ( P = 0.001), lower CD34 dose ( P = 0.006), presence of acute graft versus host disease (GVHD, P < 0.001), reactivation of cytomegalovirus infection ( P < 0.001), and presence of bacterial urinary tract infection (UTI) ( P < 0.001) were significant factors. Multivariate logistic regression confirmed the presence of acute GVHD ( P = 0.041), bacterial UTI ( P < 0.001), and residual disease ( P = 0.009) at HCT as significant risk factors for BKPyV-HC. Conclusions: Our study affirms the homogeneity of BKPyV-HC disease in low- and middle-income HCT settings with prior reports and the need for therapeutic strategies to reduce its resultant mortality.

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BK polyomavirus diversity—Why viral variation matters

Blackard

Davies

Laskin

2020

Reviews in Medical Virology

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SummaryBK polyomavirus (BKPyV or BKV) is a non‐enveloped, circular double‐stranded DNA virus that may exceed 80% seroprevalence in adults. BKV infection typically occurs during childhood, and the majority of adults are latently infected. While BKV infection is rarely associated with clinical disease in most individuals, in immunosuppressed individuals, reactivation may cause kidney (BK‐associated nephropathy) or bladder (hemorrhagic cystitis and ureteral stenosis) injury. No antiviral therapies have been approved for the treatment of BKV infection. Reducing immunosuppression is the most effective therapy, although this is not feasible in many patients. Thus, a robust understanding of viral pathogenesis and viral diversity remains important for the development of future therapeutic strategies. Studies of BKV diversity are quite sparse compared to other common viral infections; thus, much of our understanding of BVK variability and evolution relies heavily analogous studies of other viruses such as HIV or viral hepatitis. We provide a comprehensive review of BKV diversity at the population and individual level with careful consideration of how viral variability may impact viral replication, pathogenesis, tropism, and protein function. We also discuss a number of outstanding questions related to BK virus diversity that should be explored rigorously in future studies.

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BK Virus Characterisation among HIV-1-Infected Individuals and Its Association with Immunosuppression

Cited by 5 publications

References 35 publications

A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

BK polyomavirus hemorrhagic cystitis in hematopoietic cell transplant recipients

BK polyomavirus diversity—Why viral variation matters

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