Tetracycline@Silver Ions-Functionalized Mesoporous Silica for High Bactericidal Activity at Ultra-Low Concentration

Bouchmella, Karim; Campanaro, Felipe Davi; Mondo, Gabriela Borba; Santos, Murilo Izidoro; Franco, Caio Haddad; Moraes, Carolina Borsoi; Biolley, Christine; Mehdi, Ahmad; Cardoso, Mateus Borba

doi:10.2217/nnm-2018-0027

Cited by 6 publications

(16 citation statements)

References 45 publications

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“…We suggest that this significant inhibitory effect, at a low concentration of 50 ppm, might be explained by a codelivery of silver ions and amoxicillin using multifunctional Amox 30 @HDOSNPs-Ag 1 + nanoparticles adsorbed on the peptidoglycan region of the bacteria outer membrane. This codelivery hypothesis is well sustained by other materials already reported in the literature − and highlights the enormous biological potential of the nanoparticles synthesized here. It is obvious that other adjuvants and antibiotics might be used to even increase the bactericidal activity or tune nanoparticles’ properties for future biomedical applications.…”

Section: Resultssupporting

confidence: 84%

Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

et al. 2019

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The synthesis of hollow organosilica nanoparticles is described from bis triethoxysilylpropyldisulfide and bis(trimethoxylsilylpropyl)methylamine. The nanoparticles were monodisperse with a mean diameter of 90 nm, and the adsorption−desorption properties of these nanoparticles were investigated with nitrogen at 77 K, n-hexane, and water. The nanoparticles were nonporous at 77 K as shown by N 2 sorption analyses. n-Hexane interacted reversibly through physisorption with the nanoparticles, whereas water showed a strong nonreversible interaction, probably because of chemisorption with nitrogen atom sites. Amoxicillin antibiotic was loaded with these nanoparticles and the loading capacity was 30%. Ag + ions were also adsorbed with amoxicillin, and the multifunctional nanoparticles were efficient in inhibiting bacterial growth with a synergy between the antibiotic delivery and Ag + release. ■ MATERIALS AND METHODSCTAB (99%), sodium hydroxide (97%), BMSPMA, and DIS were purchased from Sigma-Aldrich. UV−vis absorption spectra were recorded on a Hewlett-Packard 8453 spectrophotometer. 29 Si solid-state NMR spectra were recorded on a

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Section: Resultssupporting

confidence: 84%

Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

et al. 2019

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“…Moreover, it should not be ignored that low pH also contributed to the dissolution balance between silver ions and silver compounds, which promoted the production of a large number of silver ions. Regarding this view, Bouchmella and co-workers 51 developed mesoporous silicon nanocomposites loaded with tetracycline and silver ions, where the release behavior was controlled by thermodynamic equilibrium. The acidic environment pushes the thermodynamic balance of silver toward the direction of silver release, thereby promoted the release of silver ions with high bactericidal activity.…”

Section: Stimuli-responsive Release Of Silver Ionsmentioning

confidence: 99%

Release Strategies of Silver Ions from Materials for Bacterial Killing

Zhang

et al. 2021

ACS Appl. Bio Mater.

106

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Silver-based antibacterial agents have attracted much attention in biomedical fields owing to their high antibacterial activity. Silver ions (Ag+) play a significant role in killing bacteria because they can readily adsorb to most biomolecules (DNA, membrane protein, enzymes, or intracellular cofactors) in bacteria to inactivate their functions. In this review, recent advances in the ways of Ag+ release from silver-contained materials were discussed. As a start, the antibacterial mechanisms of Ag+ was summarized. Then, the release strategies of Ag+ from silver-carrying materials have been categorized into two types: (1) passive release and (2) stimuli-responsive release. In particular, the stimuli-responsive materials relying on either endogenous or exogenous stimuli have been rationally designed for eliminating bacteria with high efficacy and selectivity. Future studies should focus on enhancing the controllability of Ag+ release in the infected sites of the human organs.

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“…Highly ordered mesoporous siliceous materials have been intensively investigated as supports for enzyme or protein immobilization and have also found applications in bioseparation, enzyme catalysis, biosensors, and drug delivery [ 1 , 2 , 3 , 4 , 5 ]. Among them, Santa Barbara Amorphous material (SBA-15) [ 6 , 7 ] is the most widely used.…”

Section: Introductionmentioning

confidence: 99%

Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption

et al. 2021

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Ordered mesoporous materials and their modification with multiple functional groups are of wide scientific interest for many applications involving interaction with biological systems and biomolecules (e.g., catalysis, separation, sensor design, nano-science or drug delivery). In particular, the immobilization of enzymes onto solid supports is highly attractive for industry and synthetic chemistry, as it allows the development of stable and cheap biocatalysts. In this context, we developed novel silylated amino acid derivatives (Si-AA-NH2) that have been immobilized onto SBA-15 materials in biocompatible conditions avoiding the use of toxic catalyst, solvents or reagents. The resulting amino acid-functionalized materials (SBA-15@AA) were characterized by XRD, TGA, EA, Zeta potential, nitrogen sorption and FT-IR. Differences of the physical properties (e.g., charges) were observed while the structural ones remained unchanged. The adsorption of the enzyme lysozyme (Lyz) onto the resulting functionalized SBA-15@AA materials was evaluated at different pHs. The presence of different functional groups compared with bare SBA-15 showed better adsorption results, for example, 79.6 nmol of Lyz adsorbed per m2 of SBA-15@Tyr compared with the 44.9 nmol/m2 of the bare SBA-15.

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Tetracycline@Silver Ions-Functionalized Mesoporous Silica for High Bactericidal Activity at Ultra-Low Concentration

Abstract: The combined use of tetracycline and silver ions with the mesoporous drug-delivery carrier was a very effective strategy against susceptible and tetracycline-resistant Escherichia coli bacteria.

Cited by 6 publications

References 45 publications

Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

Degradable Hollow Organosilica Nanoparticles for Antibacterial Activity

Release Strategies of Silver Ions from Materials for Bacterial Killing

Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption

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