Transgenerational Epigenetics of Traumatic Stress

Jawaid, Ali; Roszkowski, Martin; Mansuy, Isabelle M.

doi:10.1016/bs.pmbts.2018.03.003

Cited by 102 publications

(51 citation statements)

References 116 publications

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“…Different mechanisms may also operate in females and males, and systematic analyses in both genders need to be considered. Finally, an important next step will be to assess epigenetic factors in human in different body fluids such as blood, saliva, sperm or milk as initiated for some conditions and relate them to direct or ancestral exposures [4,50]. Such studies shall provide new knowledge about the etiology and mechanisms of expression of environmental pathologies and will help explain the 'missing heredity' of neuropsychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Such studies shall provide new knowledge about the etiology and mechanisms of expression of environmental pathologies and will help explain the 'missing heredity' of neuropsychiatric disorders. They may have wide-ranging implications for preventive and personalized medicine in the future [4].…”

Section: Discussionmentioning

confidence: 99%

“…Although behavioral phenotypes in the offspring can be transmitted by social and maternal factors during rearing or through passage of body fluids during delivery and/or lactation [reviewed in Refs. 3,4], true biological inheritance of acquired behavioral phenotypes involves the germline, which is the focus of this review.…”

Section: Introductionmentioning

confidence: 99%

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Inter- and transgenerational inheritance of behavioral phenotypes

Jawaid

Mansuy

2019

Current Opinion in Behavioral Sciences

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Adult animal behaviors are determined by complex and dynamic changes in gene expression in different brain regions and are influenced by life experiences and environmental exposures. These stimuli affect gene expression through intricate mechanisms of regulation that largely implicate epigenetic factors, such as, DNA methylation, histone post-translational modifications, and non-coding RNAs (ncRNAs). Through these molecular pathways, some of the behavioral phenotypes associated with life experiences can be stably transmitted to descendants, sometimes across several generations. Rodent studies indicate that parental stressful and traumatic experiences can lead to behavioral despair, risk-taking behaviors, altered sociability and atypical responses to stressful stimuli in the offspring, whereas parental environmental enrichment has been associated with improved cognition and stress resilience in the offspring. Similar observations have been made in humans; children and grandchildren of genocide survivors show increased psychopathology and emotional disturbances. At the molecular level, changes in germline ncRNAs have been identified as likely vectors of transmission in rodents. The mechanisms linking behavioral stimuli to the germline, and factors responsible for these changes and their persistence across generations remain, however, largely unidentified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Inter- and transgenerational inheritance of behavioral phenotypes

Jawaid

Mansuy

2019

Current Opinion in Behavioral Sciences

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“…Moreover, the epigenetic regulation of Nr3c1 by exposure to early-life stress is associated with increased risk for major depression and suicide in humans, and impaired behavioral and neuroendocrine responses in rats (McGowan et al, 2009;Suderman et al, 2012). In the context of early-life adversity, the epigenetic reprogramming of Nr3c1, and other regulators of stress sensitivity, is stable, persistent, and can be transmitted to the progeny (Franklin et al, 2010;Jawaid et al, 2018;Nestler, 2016). In contrast, alterations in GR expression in the adult brain upon stress exposure are not stable after the cessation of the stressor, thus, making it unlikely to be responsible for chronic depression-like phenotypes (Alt et al, 2010;Barfield and Gourley, 2018).…”

Section: Gene × Environment Interactionsmentioning

confidence: 99%

Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks

Huzard

Rappeneau

Meijer

et al. 2020

Stress

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The diversity of actions of the glucocorticoid stress hormones among individuals and within organs, tissues and cells is shaped by age, gender, genetics, metabolism, and the quantity of exposure. However, such factors cannot explain the heterogeneity of responses in the brain within cells of the same lineage, or similar tissue environment, or in the same individual. Here, we argue that the stress response is continuously updated by synchronized neural activity on large-scale brain networks. This occurs at the molecular, cellular and behavioral levels by crosstalk communication between activity-dependent and glucocorticoid signaling pathways, which updates the diversity of responses based on prior experience. Such a Bayesian process determines adaptation to the demands of the body and external world. We propose a framework for understanding how the diversity of glucocorticoid actions throughout brain networks is essential for supporting optimal health, while its disruption may contribute to the pathophysiology of stress-related disorders, such as major depression, and resistance to therapeutic treatments.

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“…Zusätzlich gibt es Hinweise, v. a. aus Tierstudien, aber auch aus Studien zum Holocaust oder anderen Genoziden [37,38], dass auch die Umwelt, der die Eltern oder sogar Großeltern ausgesetzt waren, epigenetische Unterschiede in den Kindern hervorrufen kann [39]. Mehrere Mechanismen der Übertragung sind hier möglich [40,41].…”

Section: Umwelt Und Epigenetik üBer Generationenunclassified

Umwelt und Epigenetik

Binder

2019

Nervenarzt

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Transgenerational Epigenetics of Traumatic Stress

Cited by 102 publications

References 116 publications

Inter- and transgenerational inheritance of behavioral phenotypes

Inter- and transgenerational inheritance of behavioral phenotypes

Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks

Umwelt und Epigenetik

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