Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight

Nahon, Kimberly J.; Kantae, Vasudev; Haan, Roy den; Hanssen, Mark J. W.; Harms, Amy C.; Stelt, Mario van der; Hankemeier, Thomas; Jazet, Ingrid M.; Lichtenbelt, Wouter D. van Marken; Rensen, Patrick C.N.; Boon, Mariëtte R.

doi:10.1002/oby.22245

Cited by 8 publications

(2 citation statements)

References 25 publications

(40 reference statements)

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“…In these models, an increased endocannabinoid tone (e.g. circulating endocannabinoid levels) lies at the core of the disease progression, which is in line with observations in patients suffering from high adiposity and/or obesity [39][40][41] . Therefore, it appears that CB1 antagonists can induce distinct adaptations in the same tissue, i.e.…”

Section: Discussionsupporting

confidence: 88%

The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model

Dalle

Schouten

Ramaekers

et al. 2023

Molecular and Cellular Endocrinology

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Section: Discussionsupporting

confidence: 88%

The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model

Dalle

Schouten

Ramaekers

et al. 2023

Molecular and Cellular Endocrinology

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“…For instance, knockdown or inhibition of FAAH in mice led to increased NAE levels 33 , 34 . Moreover, decreased expression of FAAH1 and FAAH2 was associated with increased levels of NAEs in the skeletal muscle of south Asian as compared with Caucasians 35 . However, the comparison of lipid mediator levels revealed few differences between psoriatic and healthy skin substitutes, with only SEA levels being increased in the psoriatic substitutes.…”

Section: Discussionmentioning

confidence: 88%

N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model

Simard

Tremblay

Morin

et al. 2023

Sci Rep

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Psoriasis is an inflammatory skin disease that is characterized by keratinocyte hyperproliferation, abnormal epidermal differentiation and dysregulated lipid metabolism. Some lipid mediators of the N-acylethanolamines (NAEs) and monoacylglycerols (MAGs) can bind to cannabinoid (CB) receptors and are referred to as part of the endocannabinoidome. Their implication in psoriasis remains unknown. The aim of the present study was to characterize the endocannabinoid system and evaluate the effects of n-3-derived NAEs, namely N-eicosapentaenoyl-ethanolamine (EPEA), in psoriatic keratinocytes using a psoriatic skin model produced by tissue engineering, following the self-assembly method. Psoriatic skin substitutes had lower FAAH2 expression and higher MAGL, ABHD6 and ABHD12 expression compared with healthy skin substitutes. Treatments with alpha-linolenic acid (ALA) increased the levels of EPEA and 1/2-docosapentaenoyl-glycerol, showing that levels of n-3 polyunsaturated fatty acids modulate related NAE and MAG levels. Treatments of the psoriatic substitutes with 10 μM of EPEA for 7 days resulted in decreased epidermal thickness and number of Ki67 positive keratinocytes, both indicating decreased proliferation of psoriatic keratinocytes. EPEA effects on keratinocyte proliferation were inhibited by the CB1 receptor antagonist rimonabant. Exogenous EPEA also diminished some inflammatory features of psoriasis. In summary, n-3-derived NAEs can reduce the psoriatic phenotype of a reconstructed psoriatic skin model.

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The life‐course changes in muscle mass using dual‐energy X‐ray absorptiometry: The China BCL study and the US NHANES study

Wang,

Gao,

Xiong

et al. 2024

J cachexia sarcopenia muscle

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BackgroundSarcopenia is an important indicator of ill health and is linked to increased mortality and a reduced quality of life. Age‐associated muscle mass indices provide a critical tool to help understand the development of sarcopenia. This study aimed to develop sex‐ and age‐specific percentiles for muscle mass indices in a Chinese population and to compare those indices with those from other ethnicities using the National Health and Nutrition Examination Survey (NHANES) data.MethodsWhole‐body and regional muscle mass was measured by dual‐energy X‐ray absorptiometry (DXA) in participants of the China Body Composition Life‐course (BCL) study (17 203 healthy Chinese aged 3–60 years, male 48.9%) and NHANES (12 663 healthy Americans aged 8–59 years, male 50.4%). Age‐ and sex‐specific percentile curves were generated for whole‐body muscle mass and appendicular skeletal muscle mass using the Generalized Additive Model for Location Scale and Shape statistical method.ResultsValues of upper and lower muscle mass across ages had three periods: an increase from age 3 to a peak at age 25 in males (with the 5th and 95th values of 41.5 and 66.4 kg, respectively) and age 23 in females (with the 5th and 95th values of 28.4 and 45.1 kg, respectively), a plateau through midlife (30s–50s) and then a decline after their early 50s. The age at which muscle mass began to decline was 52 years in men with the 5th and 95th percentile values of 43.5 and 64.6 kg, and 51 years in women with the 5th and 95th percentile values of 31.6 and 46.9 kg. Appendicular skeletal muscle mass decreased earlier than whole body muscle mass, especially leg skeletal muscle mass, which decreased slightly after age 49 years in both sexes. In comparison with their US counterparts in the NHANES, the Chinese participants had lower muscle mass indices (all P < 0.001) and reached a muscle mass peak earlier with a lower muscle mass, with the exception of similar values compared with adult Mexican and White participants. The muscle mass growth rate of Chinese children decreased faster than that of other races after the age of 13.ConclusionsWe present the sex‐ and age‐specific percentiles for muscle mass and appendicular skeletal muscle mass by DXA in participants aged 3–60 from China and compare them with those of different ethnic groups in NHANES. The rich data characterize the trajectories of key muscle mass indices that may facilitate the clinical appraisal of muscle mass and improve the early diagnosis of sarcopenia in the Chinese population.

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Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight

Abstract: South Asian men with overweight have higher plasma 2-linoleoyl glycerol and N-linoleoylethanolamine levels and lower expression of CB receptors and the endocannabinoid degradation enzyme FAAH2 in skeletal muscle compared to white Caucasians.

Cited by 8 publications

References 25 publications

The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model

The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model

N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model

The life‐course changes in muscle mass using dual‐energy X‐ray absorptiometry: The China BCL study and the US NHANES study

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