Comparison of graft and patient survival according to the transplantation centre policy for 1-year screening biopsy among stable kidney recipients: a propensity score-based study

Couvrat-Desvergnes, Grégoire; Foucher, Yohann; Borgne, Françoise Le; Dion, Angélina; Mourad, Georges; Garrigue, Valérie; Legendre, Christophe; Rostaing, Lionel; Kamar, Nassim; Kessler, Michèle; Ladrière, Marc; Morélon, Emmanuel; Buron, Fanny; Giral, Magali; Dantan, Étienne

doi:10.1093/ndt/gfy221

Cited by 10 publications

(1 citation statement)

References 39 publications

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“…A perspective of the network will be to work progressively to increase the number and the precision of the collected parameters. However, since several centers that participate to the EKITE cohort [17] do not practice surveillance biopsies it makes difficult to enter pathology findings on the database. Concerning DSA immunization, it was not possible to retrospectively collect this parameter.…”

Section: Utility and Discussionmentioning

confidence: 99%

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

et al. 2019

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Background Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD prevalence in Europe, it is essential to improve transplantation outcomes by studying the related prognostic factors. Today, there is no European registry collecting data to perform such clinical epidemiology studies. Main body Entitled EKiTE, for European cohort for Kidney Transplantation Epidemiology, this prospective and multicentric cohort includes patients from Spanish (Barcelona), Belgian (Leuven), Norwegian (Oslo) and French (Paris Necker, Lyon, Nantes, Nancy, Montpellier, Nice and Paris Saint Louis) transplantation centers and currently contains 13,394 adult recipients of kidney (only) transplantation from 2005 and updated annually. A large set of parameters collected from transplantation until graft failure or death with numbers of post-transplantation outcomes. The long-term follow-up and the collected data enable a wide range of possible survival and longitudinal analyses. Conclusion EKiTE is a multicentric cohort aiming to better assess the natural history of the ESRD in European kidney transplant recipients and perform benchmarking of clinical practices. The data are available for clinical epidemiology studies and open for external investigators upon request to the scientific council. Short-term perspectives are to extend EKITE network to other European countries and collect additional parameters in respect of the common thesaurus.

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Section: Utility and Discussionmentioning

confidence: 99%

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

et al. 2019

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COPP-MS: COrticosteroids during the Post-Partum in relapsing Multiple Sclerosis patients

et al. 2022

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Background:No specific treatment has demonstrated its effectiveness to prevent postpartum relapses for multiple sclerosis (MS) women.Objective: To assess the effectiveness of preventive high-dose corticosteroids in the post-partum period by comparing two strategies: (1) no preventive treatment and (2) standardized preventive treatment. Methods:We selected 5 French Multiple Sclerosis centers using the same post-partum strategy for their patients -either high-dose steroids (treating centers TC) or no treatment (non-treating centers NTC). We included relapsing-remitting multiple sclerosis women who delivered between January 2007 and January 2017. Our primary outcomes were the time from delivery to first relapse, EDSS progression and MRI activity between patients of treating centers and non-treating centers, after propensityscore weighting.Results: 350 patients were included (116 from treating centers, 234 from non-treating centers). For both groups, the annualized relapse rate decreased during pregnancy (0.28 in treating centers and 0.34 in non-treating centers during the third trimester) and increased during the first post-partum trimester (0.45 and 0.69 respectively) with 11% and 14% (NS) of patients facing at least one relapse respectively. Our primary outcomes were not statistically different between both groups. Conclusion:This study provides class III evidence that systematic high-dose corticosteroids are not associated with a reduced inflammatory activity during the postpartum period in multiple sclerosis patients.

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Identification d’un score permettant le diagnostic du rejet infraclinique en transplantation rénale

Brouard,

Kerleau,

Giral

et al. 2024

Bulletin de l'Académie Nationale de Médecine

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Comparison of graft and patient survival according to the transplantation centre policy for 1-year screening biopsy among stable kidney recipients: a propensity score-based study

Abstract: A 1-year SB policy for stable patients may not lead to therapeutical benefits for improved graft and patient survival. Further studies examining the benefits versus the risks of a 1-year SB policy are warranted to demonstrate the long-term utility of this intervention.

Cited by 10 publications

References 39 publications

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

COPP-MS: COrticosteroids during the Post-Partum in relapsing Multiple Sclerosis patients

Identification d’un score permettant le diagnostic du rejet infraclinique en transplantation rénale

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