Largest known malignant solitary fibrous tumour of the pleura-extended resection warranting cardiopulmonary bypass support

Shanahan, Ben; Redmond, Karen

doi:10.1007/s11845-018-1879-x

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…For patients with a large tumor or extensive adhesions, thoracotomy is often used, and in case of incomplete resection or recurrence, the secondary operation may be needed (51,52). Originated from the pleural wall, extrapleural resection can be carried out without removing the chest wall (53), and patients with pericardial cavity involvement may need cardiopulmonary bypass support (54). Preoperative percutaneous embolization has been reported to reduce the risk of intraoperative bleeding significantly; however, SFTP embolization may lead to a rare potential life-threatening complication (55).…”

Section: Discussionmentioning

confidence: 99%

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Zuo¹,

Zhou²,

Sun³

et al. 2020

Ann Transl Med

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A solitary fibrous tumor (SFT) is a rare spindle cell tumor-derived from mesenchymal cells. It may be linked to the fusion of the NAB2-STAT6 gene caused by 12q chromosome rearrangement. It can occur in the connective tissue of any part of the body; however, it is most common in the pleura. Solitary fibrous tumors of the pleura (SFTP) are a persistent painless mass with slow growth. With the increase of the tumor, there will be corresponding compression symptoms. Pleural effusion is rare, and the cytology of pleural effusion is mostly negative. Occasionally, SFTP can induce paraneoplastic syndrome, distant metastasis, and malignant transformation. Lung function may have mild to moderate restrictive ventilation dysfunction. CT is a crucial method for the clinical diagnosis of SFTP. The histopathological features of SFTP are the coexistence of sparse and dense areas. CD34, CD99, Bcl-2, and vimentin are the most valuable immunohistochemical markers.The positive expression rate of STAT6 in benign SFT was even 100%. Adhesion or unclear boundary with surrounding tissues, pleural effusion or calcification, tumors with a maximum diameter greater than 10 cm, invasive growth, uneven density, metastasis or recurrence, paraneoplastic syndrome, moderate to severe cell heterogeneity, high Ki67 proliferation index, and low STAT6 expression suggest SFTP may be a malignant tumor. Gene analysis on next generation sequencing may help reveal the mutation characteristics of SFTP. Complete tumor resection is the gold standard of SFTP. Resectability is the most important prognostic factor. Age, size, mitosis, and necrosis are considered risk stratification factors for prognosis. Fortunately, 80% of SFTP are benign and have anexcellentprognosis but need long-term follow-up.We report a case of rapidly growing tumor with pleural effusion within 9 months, who was surgically treated and is currently under follow-up. And the literature is reviewed.

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Section: Discussionmentioning

confidence: 99%

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Zuo¹,

Zhou²,

Sun³

et al. 2020

Ann Transl Med

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“…Approximately 5-27% of SFTs occur in the head and neck region [39] with the oral cavity [40] and the orbit [39] being the most commonly affected sites. A few studies showed that pelvic [27,30,41], abdominal [27,42], and pleural [27,40,43] SFTs tend to be larger than tumors appearing in other locations, and extrapleural SFTs may show potentially malignant behavior [44], especially those with limb localization [45]. Generally, over the years, SFTs have been described in various localizations, including the liver [46,47], kidney [48][49][50], pancreas [23,51,52], sigmoid colon [31], mesocolon [14], omentum [53,54], urinary bladder [55], caecum wall [56], mesorectum [41], prostate [57], spermatic cord [58], testis [59], scrotum [60], female gynecological tract, especially the vulva [61,62], vagina [63], breast [64][65][66], heart and pericardium [33,67,68], epicardium [69], pulmonary artery [70], trachea…”

Section: Anatomical Locationmentioning

confidence: 99%

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification of Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to the lack of characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis of SFT is often associated with the presence of fusions of the NAB2-STAT6 gene on the 12q13 chromosome. Cytoplasmic CD34 positive staining is considerably characteristic for most SFTs; less frequently, factor XII, vimentin, bcl-2, and CD99 are present. A key factor in the diagnosis is the prevalent nuclear location of STAT6 expression. Radical resection is the mainstay of localized SFTs. In the case of unresectable disease, only radiotherapy or radio-chemotherapy may significantly ensure long-term local control of primary and metastatic lesions. To date, no practical guidelines have been published for the treatment of advanced or metastatic disease. Classical anthracycline-based chemotherapy is applicable. The latest studies suggest that antiangiogenic therapies should be considered after first-line treatment. Other drugs, such as imatinib, figitumumab, axitinib, and eribulin, are also being tested. Definitive radiotherapy appears to be a promising therapeutic modality. Since standards for the treatment of advanced and metastatic diseases are not available, further investigation of novel agents is necessary.

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Largest known malignant solitary fibrous tumour of the pleura-extended resection warranting cardiopulmonary bypass support

Cited by 2 publications

References 6 publications

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

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