A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk

Du, Haina; Song, Guoxin; Fang, Mingzhi; Shu, Yongqian; Zhao, Xin; Zhu, Lingjun

doi:10.7555/jbr.32.20160030

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…These highlight findings are also consistent with a previous report investigating the contribution of Cas- have conducted a meta-analysis to investigate the association between the Cas-8 rs3834129 polymorphisms and the risk for digestive tract cancers (39). They found an evident association between Cas-8 rs3834129 polymorphisms and reduced digestive cancer risk, especially for Asians (22). Future studies investigating the association of Cas-8 rs3834129 polymorphism and the risk of NPC in larger and different populations are urgently required to confirm our findings.…”

Section: Discussionsupporting

confidence: 91%

“…There are at least 353 SNPs in Cas-8 reported in the NCBI dbSNP database. Cas-8 SNPs, such as D302H (rs1045485), IVS12-19G/A (rs3769818), and the promoter rs3834129 that will be the focus of the current study, have been reported to be potential genomic markers for the prediction of risk for several types of cancer such as neuroblastoma (17), breast cancer (18)(19)(20), lung cancer (21), digestive tract cancer (22,23), prostate cancer (24), and bladder cancer (25). However, the role of Cas-8 polymorphisms in NPC is not known.…”

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confidence: 99%

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Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan

et al. 2020

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Background/Aim: Accumulating evidence shows that caspase-8 (Cas-8) rs3834129 genotypes determine susceptibility to various cancers, but their association with nasopharyngeal carcinoma (NPC) has not been examined. We aimed at investigating the association of Cas-8 rs3834129 with NPC risk. Materials and Methods: Cas-8 rs3834129 genotypes and their associations with NPC risk were investigated among 176 NPC patients and 352 non-cancer subjects by the PCR-RFLP method. Additionally, the interaction of Cas-8 rs3834129 genotypes with smoking was examined. Results: The II, ID and DD frequencies were 56.8, 36.9 and 6.3% among NPC patients and 54.8, 38.1 and 7.1% among control subjects (p trend =0.8830). Allelic frequency distribution analysis also indicated that the D allele is not a risk factor for NPC (p=0.6183). There was no interaction between . Conclusion: Cas-8 rs3834129 genotypes play a minor role in the risk for NPC.Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is a rapidly growing squamous cell carcinoma in nasopharynx *These Authors contributed equally to this study.

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan

et al. 2020

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“…This leads to mitochondrial permeabilization executed by BCL2-associated X protein and BCL2 antagonist/killer protein (5). As for the association between CASPs and cancer, Du et al (13) explored the effects of a six-nucleotide deletion polymorphism of the CASP8 gene in the digestive tract on the risk of cancer development; all genetic models exhibited protection against the development of GC. The antitumor effects of CASPs were also investigated by Kanehara et al (14), in which the degree of CASP8 activation could indicate the anticancer potential of this CASP.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of mRNA expression of CASPs in gastric cancer

Wang

et al. 2019

Oncol Lett

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Current studies suggest that the cysteinyl aspartate specific proteinase (caspase/CASP) family may be closely associated with apoptosis. Scientists have suggested that caspases may be a key to the development of more effective anti-cancer therapies. However, the prognostic value of CASP expression in gastric cancer (GC) remains unclear. Using a Kaplan-Meier plotter online database, the predictive prognostic significance of the expression of 12 CASPs genes (CASP1, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CASP10, CASP12 and CASP14) to overall survival (OS) in different clinicopathological features, including Lauren classification, pathological stages, therapies employed and differentiation in gastric cancer patients was explored. The present study revealed that higher CASP1, 2, 3, 4, 5, 6, 7 and 8 mRNA expression was associated with better OS, whereas higher expression of CASP9, 10, 12 and 14 showed an unfavorable OS in all GC patients. Moreover, CASP1 to 8 were all associated with favorable OS in intestinal type and diffuse type classified by Lauren classification. Therefore, the results of the present study suggested that the CASP family may function as new prognostic indicators in GC and may be helpful in making treatment decisions.

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“…Among the polymorphic sites of CASP8, rs3834129 (-652, 6N ins/del) polymorphism, a six-nucleotide insertion (I)/deletion (D) variant, has been functionally identified to lead to down-regulation of the mRNA of CASP8 (18). Caspase-8 single nucleotide polymorphisms are reported to be genomic markers for the prediction of the personal risk for several types of cancers such as that of the digestive tract (19,20), breast (21)(22)(23), prostate (24), lung (25) and bladder (26), and neuroblastoma (27). Little is known about the role of CASP8 polymorphisms in oral cancer.…”

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Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan

Shih

Tsai

Sun

et al. 2019

In Vivo

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Background/Aim: Recently, mounting evidence has shown that caspase-8 (CASP8) rs3834129 (-652, 6N insertion/deletion) polymorphism may serve as a genetic biomarker for personal risk of various cancer types. The contribution of CASP8 rs3834129 polymorphism has been investigated in several oral cancer populations, but not in Taiwan. This study investigated the role of CASP8 rs3834129 polymorphism on oral risk in Taiwan. Materials and Methods: CASP8 rs3834129 polymorphic genotypes were determined and their associations with oral cancer risk were investigated among 788 patients with oral cancer and 956 age-and gender-matched healthy controls via polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) methodology. In addition, the interaction of CASP8 rs3834129 genotype with personal behavior and clinicopathological features were also examined. Results: The frequencies of II, ID and DD genotypes for CASP8 rs3834129 were 57.5, 36.5 and 6.0% in the patient group and 54.0, 39.0 and 7.0% in the healthy control group, respectively (p for trend=0.3052), genotypes were not significantly differentially distributed between the two groups. The comparisons in allelic frequency distribution also supported the findings that the D variant allele may not serve as a determinant of risk for oral cancer. There was no interaction of CASP8 rs3834129 genotype with age, gender, smoking, alcohol or betel quid consumption in regard to oral cancer risk. Conclusion: Our results indicate that the caspase-8 genotype does not appear to play a direct role in personal susceptibility to oral cancer in Taiwan. Oral cancer is the eighth most commonly diagnosed cancer among men in the world, and about twice more prevalent than among women in the world (1). In Taiwan, the incidence and mortality of oral cancer has occupied the fourth and fifth places among the common cancer types for many years (2), and its high incidence has been proposed to be closely associated with the combinative effects of smoking, alcoholism and, betel quid chewing in addition to genetic factors (3-6). However, the definitive genomic etiology of oral cancer remains largely unknown. In Taiwan, although several useful biomarkers for early detection of oral cancer have been revealed (7-13), the mechanisms underlying them are largely unknown and practical genomic markers for clinical use are still in urgent need. Noticeably, Taiwan has over of the highest densities worldwide of patients with oral cancer. Apoptosis is a bio-essential mechanism for altering the morphology, and controlling the death rate of a stable population (14). In the literature, mounting evidence has shown loss of homeostasis of the apoptosis pathway to be associated with the development of oral cancer (15), and 1151 This article is freely accessible online.

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A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk

Cited by 5 publications

References 28 publications

Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan

Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan

Prognostic significance of mRNA expression of CASPs in gastric cancer

Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan

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