Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites

Kumar, Amit; Smith, Carolyne K.; Jobin, Christian; Trinchieri, Giorgio; Howcroft, T. Kevin; Seifried, Harold E.; Espey, Michael Graham; Flores, Roberto; Kim, Young S.; Daschner, Phillip J.

doi:10.1093/jnci/djx040

Cited by 7 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perturbations in lipid metabolism can affect the progression of cancers through effects on the stem cell character of tumor cells, angiogenesis, and immune surveillance [38,39]. The metabolites associated with the tumor immune response and thus affect the relationship between the gut microbiota and disease [40]. In our study, spermine, which belongs to polyamines, have been attributed to human cancers [41,42], was increased in the BM group compared with the NBM group.…”

Section: Discussionmentioning

confidence: 59%

Microbiota-modulated spermine promotes brain metastasis in non-small cell lung cancer by regulating microglia M2 polarization via the STAT3 pathway

Liu

Bin

et al. 2022

Preprint

View full text Add to dashboard Cite

Brain metastasis (BM) is associated with high mortality in patients with non-small cell lung cancer (NSCLC). Alterations in the gut microbiota have been implicated in modulation of brain disorders through the gut-brain-axis (GBA). However, the underlying mechanism by which the gut microbiota affects the development of BM in NSCLC remains largely unknown. In patients, we identified 16 genera of differential bacteria positively or negatively correlated with BM in NSCLC patients, as represented by Klebsiella, unclassified_f_Enterobacteriaceae and Alistipes by 16S rRNA gene sequencing. In addition, untargeted metabolomics (LC-MS/MS and GC/MS) identified 76 metabolites, that were associated with BM. The combination of intestinimonas and spermine was considered a potential marker for the diagnosis of BM in NSCLC. Moreover, the plasma metabolite spermine enhanced BM by promoting M2 polarization of microglia via activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway in vivo and in vitro, suppressing innate immune function, which in turn promoted tumor progression. Overall, our study demonstrated the composition of both the gut microbiota and metabolites changed significantly between groups, and revealed that metabolite spermine promotes BM by skewing the polarity of M2 microglia by activating STAT3 signals. Our results provide a novel perspective regarding host-gut microbiota interplay in BM of NSCLC and highlight a potential risk of spermine in promoting BM.

show abstract

Section: Discussionmentioning

confidence: 59%

Microbiota-modulated spermine promotes brain metastasis in non-small cell lung cancer by regulating microglia M2 polarization via the STAT3 pathway

Liu

Bin

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…An important contributor of chronic mucosal inflammation is the microbiome [100][101][102][103][104][105][106][107][108][109][110]. Recent data show that oral microbial dysbiosis, with enrichment of Fusobacterium species, is associated with advanced oral cavity cancer stage; however, how this dysbiosis contributes to tumor progression remains an open question [111].…”

Section: The Microbiome As a Primer For Inflammation And Hpv Mediated...mentioning

confidence: 99%

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

McKeon

Gallant

Kim

et al. 2022

Cancers

View full text Add to dashboard Cite

While the two primary risk factors for head and neck squamous cell carcinoma (HNSCC) are alcohol and tobacco, viruses account for an important and significant upward trend in HNSCC incidence. Human papillomavirus (HPV) is the causative agent for a subset of oropharyngeal squamous cell carcinoma (OPSCC)—a cancer that is impacting a rapidly growing group of typically middle-aged non-smoking white males. While HPV is a ubiquitously present (with about 1% of the population having high-risk oral HPV infection at any one time), less than 1% of those infected with high-risk strains develop OPSCC—suggesting that additional cofactors or coinfections may be required. Epstein–Barr virus (EBV) is a similarly ubiquitous virus that is strongly linked to nasopharyngeal carcinoma (NPC). Both of these viruses cause cellular transformation and chronic inflammation. While dysbiosis of the human microbiome has been associated with similar chronic inflammation and the pathogenesis of mucosal diseases (including OPSCC and NPC), a significant knowledge gap remains in understanding the role of bacterial-viral interactions in the initiation, development, and progression of head and neck cancers. In this review, we utilize the known associations of HPV with OPSCC and EBV with NPC to investigate these interactions. We thoroughly review the literature and highlight how perturbations of the pharyngeal microbiome may impact host-microbiome-tumor-viral interactions—leading to tumor growth.

show abstract

“…An important contributor of chronic mucosal inflammation is the microbiome [85][86][87][88][89][90][91][92][93][94][95]. Recent data show that oral microbial dysbiosis, with enrichment of Fusobacterium species, is associated with advanced oral cavity cancer stage; but, how this dysbiosis contributes to tumor progression remains an open question [96].…”

Section: The Microbiome As a Primer For Inflammation And Hpv Mediated...mentioning

confidence: 99%

It Takes Two to Tango; A Review of Oncogenic Virus and Host Microbiome Associated Inflammation on Head and Neck Cancer

McKeon¹,

Gallant²,

Kim³

et al. 2022

Preprint

View full text Add to dashboard Cite

While the two primary risk factors for head and neck squamous cell carcinoma (HNSCC) are alcohol and tobacco, viruses account for an important and significant upward trend in HNSCC incidence. Human papillomavirus (HPV) is the causative agent for a subset of oropharyngeal squamous cell carcinoma (OPSCC)—a cancer that is impacting a rapidly growing group of typically middle-aged non-smoking white males. While HPV is a ubiquitously present virus (with about 7% of the population having oral HPV infection at any one time), only 1% of those infected develop OPSCC— suggesting that additional cofactors or coinfections may be required. Epstein-Barr virus (EBV) is a similarly ubiquitous virus that is strongly linked to nasopharyngeal carcinoma (NPC). Both of these viruses cause cellular transformation and chronic inflammation. While dysbiosis of the human microbiome has been associated with similar chronic inflammation and the pathogenesis of mucosal diseases (including OPSCC and NPC), a significant knowledge gap remains in understanding the role of bacterial-viral interactions in the initiation, development, and progression of head and neck cancers. In this review, we utilize the known associations of HPV with OPSCC and EBV with NPC to investigate these interactions. We thoroughly review the literature and highlight how perturbations of the pharyngeal microbiome may impact host-microbiome-tumor-viral interactions—leading to tumor growth.

show abstract

Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites

Cited by 7 publications

References 44 publications

Microbiota-modulated spermine promotes brain metastasis in non-small cell lung cancer by regulating microglia M2 polarization via the STAT3 pathway

Microbiota-modulated spermine promotes brain metastasis in non-small cell lung cancer by regulating microglia M2 polarization via the STAT3 pathway

It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer

It Takes Two to Tango; A Review of Oncogenic Virus and Host Microbiome Associated Inflammation on Head and Neck Cancer

Contact Info

Product

Resources

About