Comparison of Cerebrospinal Fluid Cytokine Levels in Children of Enteroviral Meningitis With Versus Without Pleocytosis

Park, Su Eun; Shin, Kyung‐Hwa; Song, Duyeal; Nam, Sang Ook; Kim, Kyung Min; Lyu, Soo Young; Kim, Young A; Kong, Jai-Yul; Kim, Young Mi; Yeon, Gyu Min; Lee, Yun-Jin

doi:10.1089/jir.2018.0002

Cited by 10 publications

(8 citation statements)

References 26 publications

(2 reference statements)

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“…The mean age of EV-positive patients in our centers was 15 (3.25; 32.75) years, which accurately fits to previous data of Shandong [8] and Finland [9] (Finland 2009 15 years 8 months, Finland 2010 17 years 6 months, Shandong 2014 children within 15 years of age). The mean age of EV-negative pediatric patients (8 (7.25; 14.75) years) in our cohort was quite similar to that in a large South Korean pediatric cohort (8.4 ± 5 years) [31].…”

Section: Discussionsupporting

confidence: 76%

Meningitis gone viral: description of the echovirus wave 2013 in Germany

et al. 2019

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BackgroundAseptic meningitis epidemics may pose various health care challenges.MethodsWe describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases.ResultsA total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and 1 EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home.ConclusionsVoluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.

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Section: Discussionsupporting

confidence: 76%

Meningitis gone viral: description of the echovirus wave 2013 in Germany

et al. 2019

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“…and Finland 9 (Finland 2009 15 years 8 months, Finland 2010 17 years 6 months, Shandong 2014 children within 15 years of age). The mean age of EV-negative pediatric patients (8 (7.25; 14.75) years) in our cohort was quite similar to that in a large South Korean pediatric cohort (8.4 ± 5 years)31 .…”

supporting

confidence: 80%

Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany

Graf

Hartmann

Lehmann

et al. 2019

Preprint

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BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. METHODS: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases.RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and one EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. CONCLUSIONS: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.

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“…8 months, Finland 2010 17 years 6 months, Shandong 2014 children within 15 years of age). The mean age of EV-negative pediatric patients(8 (7.25; 14.75) years) in our cohort was quite similar to that in a large South Korean pediatric cohort (8.4 ± 5 years)30 .Conclusion EV-positive epidemics are similar in terms of age and gender distribution and other factors worldwide. Overall, this entity remains a rather benign form of meningitis with a rather short length of stay in hospital, but may be associated with complicated courses that may lead to persistent neurological disability or even death.…”

supporting

confidence: 78%

Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany

Graf

Hartmann

Lehmann

et al. 2019

Preprint

View full text Add to dashboard Cite

BACKGROUND: Aseptic meningitis epidemics may pose various health care challenges. OBJECTIVE: We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1 st and December 31 st , 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. RESULTS: A total of 72 enterovirus (EV-positive) meningitis cases were detected in our multicenter cohort, corresponding to 5.8% of all EV-positive cases which were voluntarily reported within the National Enterovirus surveillance (EVSurv, based on investigation of patients with suspected aseptic meningitis/encephalitis and/or acute flaccid paralysis) by physicians within this period of time. Among these 72 patients, 38 (52.8%) were enterovirus positive and typed as echovirus (18 pediatric and 20 adult cases, median age 18.5 years; echovirus 18 (1), echovirus 2 (1), echovirus 30 (31), echovirus 33 (1), echovirus 9 (4)). At the same time, 45 aseptic meningitis cases in our cohort were excluded to be due to enteroviral infection (EV-negative). Three EV-negative patients were tested positive for varicella zoster virus (VZV) and one EV-negative patient for herpes simplex virus 2. Hospitalization was significantly longer in EV-negative cases. Cerebrospinal fluid analysis did not reveal significant differences between the two groups. After discharge, EV-meningitis resulted in significant burden of sick leave in our pediatric cohort as parents had to care for the children at home. CONCLUSION: Voluntary syndromic surveillance, such as provided by the EVSurv in our study may be a valuable tool for epidemiological research. Our analyses suggest that EV-positive meningitis predominantly affects younger patients and may be associated with a rather benign clinical course, compared to EV-negative cases.

show abstract

Comparison of Cerebrospinal Fluid Cytokine Levels in Children of Enteroviral Meningitis With Versus Without Pleocytosis

Cited by 10 publications

References 26 publications

Meningitis gone viral: description of the echovirus wave 2013 in Germany

Meningitis gone viral: description of the echovirus wave 2013 in Germany

Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany

Meningitis gone viral: Description of the Echovirus Wave 2013 in Germany

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