Highly selective N-glucuronidation of four piperazine-containing drugs by UDP-glucuronosyltransferase 2B10

Abstract

CL: intrinsic clearance; CL: maximal clearance; HLM: human liver microsomes; K: Michaelis-Menten constant; K: substrate inhibition constant; MS: mass spectroscopy; NNAL: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; QTOF: Quadrupole time-of-flight; S: the substrate concentration resulting in 50% of V; UDP-GlcA: uridine diphosphoglucuronic acid; UGT: UDP-glucuronosyltransferase; UPLC: ultra performance liquid chromatography; V: maximal velocity.