Human papillomavirus (HPV) shedding in breast milk from African women living with HIV

Diaz, Sophie; Boulle, Nathalie; Molès, Jeàn-Pierre; Peries, Marianne; Rutagwera, David; Kankasa, Chipepo; Tumwine, James K; Perre, Philippe Van de; Segondy, Michel

doi:10.1016/j.jcv.2018.07.004

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…In addition, HPV infection was also reported in adjacent normal and benign breast tissue (Table 1) (57) as well as in BC cell lines MDA-MB-175-VII, SK-BR-3 and MCF7 (20,38). HPV infection was also reported in nipple tissue, breast ductal lavage, nipple discharge and even from breast milk (8,(58)(59)(60)(61)(62). Interestingly, presence of HPV was also observed in the serum-derived extracellular vesicles (58).…”

Section: Prevalence Of Hpv Infection In Breastmentioning

confidence: 87%

Human papilloma virus (HPV) profiles in breast cancer: future management

Islam¹,

Chakraborty²,

Panda³

2020

Ann Transl Med

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Breast cancer (BC) is frequent among women in worldwide as well as in India. Several studies have reported a wide variation (1.6-86.2%) in the frequency of incidence of human papillomavirus (HPV) infection in BC with high prevalence of high risk HPV16 subtype. HPV infection in breast can occur through different routes like body fluid or by micro-lesion of breast skin from genital/agential sites, though the actual mode of HPV transmission is not yet known in details. Frequent integration and sequence variation with low copy number of HPV16 were seen in this tumour. In addition, high frequencies of methylation in p97 promoter region of HPV16 were evident in this tumour. Novel splice variants of E6/E7 along with other common variants and their protein expression were seen in the tumour. This indicates the importance of HPV in this tumor, its early diagnosis and prognosis. Thus, HPV may be targeted through vaccination to control the disease. However, detailed analysis of HPV associated molecular pathogenesis of BC is warranted for proper therapeutic intervention.

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Section: Prevalence Of Hpv Infection In Breastmentioning

confidence: 87%

Human papilloma virus (HPV) profiles in breast cancer: future management

Islam¹,

Chakraborty²,

Panda³

2020

Ann Transl Med

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“… 40 , 41 Early protein 5 (E5) can affect receptor tyrosine kinases by associating with the cell membrane. HPV DNA has been reported to be found in human breast milk, indicating that the virus can certainly infect and accumulate in breast tissue, 42 , 43 while some studies 44 , 45 indicated that HPV DNA was not found in breast milk. Understanding how breast milk is infected with HPV and clarifying the effect of this infection on HPV transmission and its possible involvement in HPV-induced carcinogenesis are still unknown, but there are potent suggestions to explain how breast milk is infected.…”

Section: Human Oncogenic Dna Virusesmentioning

confidence: 99%

The Role of DNA Viruses in Human Cancer

2023

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This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi’s Sarcoma Herpesvirus (Kaposi’s Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world.

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“…Various factors may contribute to the risk of HPV transmission, such as the presence of cervical warts in the mother (condylomata acuminata, cervical dysplasia, cervical cancer) [ 17 ], maternal age and history of immunosuppression (e.g., HIV) [ 47 , 48 ]. Nevertheless, some children tested positive for HPV DNA although apparently their parents did not have a HPV-related disease.…”

Section: Discussionmentioning

confidence: 99%

Detection of Human Papillomaviruses in the Nasopharynx of Breastfed Infants: New Findings and Meta-Analysis

Dassi

Annunziata

Botti

et al. 2020

Viruses

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Vertical transmission of human papillomaviruses (HPVs) from mother to infant is known to occur during labor, delivery or breastfeeding. Infection with mucosal HPV 6 and 11 may cause recurrent respiratory papillomatosis in children, which is a rare and severe respiratory disease. The cutaneous HPV genotypes have also been described to be transmitted from mother to newborn through skin-to-skin contacts and during breastfeeding. To investigate the perinatal transmission of alpha and beta HPVs we collected nasopharyngeal specimens from 0–12-months-old infants born by vaginal delivery and breastfed at the time of sample collection. The mucosal and cutaneous HPVs were searched by nested PCR using the MY09/11-MGPs and CP65/70-CP66/69 primer sets, respectively, and genotypes identified by direct sequencing analysis. Fourteen out of 113 (12.4%) samples tested positive for HPV and sequence analysis allowed us to identify eight beta genotypes (HPV 5b, 20, 25, 100, 107, 124, 152 and RTRX7). Moreover, we performed a comprehensive review of published studies on the prevalence of mucosal and cutaneous HPVs among 5126 newborns and observed that 10% and 53% were positive for alpha and beta HPVs, respectively. In all studies there was an inverse correlation between the rate of alpha HPV positivity and age, while a significant positive trend was observed in beta HPV detection and age with the highest rate among children older than 12 months (Χ2 test for trend of 10.6, p < 0.001). Further studies are needed to confirm the hypothesis that beta HPVs are transmitted to breastfeeding infants through shedding of viruses in the breast milk or on the external breast epithelium.

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Human papillomavirus (HPV) shedding in breast milk from African women living with HIV

Cited by 6 publications

References 18 publications

Human papilloma virus (HPV) profiles in breast cancer: future management

Human papilloma virus (HPV) profiles in breast cancer: future management

The Role of DNA Viruses in Human Cancer

Detection of Human Papillomaviruses in the Nasopharynx of Breastfed Infants: New Findings and Meta-Analysis

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