Does AMH Relate to Timing of Menopause? Results of an Individual Patient Data Meta-Analysis

Depmann, Martine; Eijkemans, Marinus J.C.; Broer, Simone L.; Tehrani, Fahimeh Ramezani; Solaymani‐Dodaran, Masoud; Azizi, Fereidoun; Lambalk, Cornelis B.; Randolph, John F.; Harlow, Sioḃán D.; Freeman, Ellen W.; Sammel, Mary D.; Verschuren, W M Monique; Schouw, Yvonne T. van der; Mol, Ben Willem J.; Broekmans, Frank J.

doi:10.1210/jc.2018-00724

Cited by 70 publications

(60 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Every AMH level decrease of around 0.10 ng/mL was related with a 14% increased risk of early menopause (p < 0.001). Furthermore, a metaanalysis of 2,596 female patients (of whom 1,077 were menopausal) showed that the combination of AMH and age was more reliable in the prediction of early menopause than age alone [53]. Despite all the studies, more accurate threshold for AMH level needs to be defined, and other variables, such as family history of early menopause, maternal age at menopause, and lifestyle factors (smoking, body mass index [BMI], use of alcohol, and parity) should also be considered.…”

Section: Use As a Marker For Predicting Age At Menopausementioning

confidence: 99%

Clinical application of serum anti-Müllerian hormone in women

Choe

Cho

2019

Clin Exp Reprod Med

View full text Add to dashboard Cite

Anti-Müllerian hormone (AMH), a peptide growth factor of the transforming growth factor-β family, is a reliable marker of ovarian reserve. Regarding assisted reproductive technology, AMH has been efficiently used as a marker to predict ovarian response to stimulation. The clinical use of AMH has recently been extended and emphasized. The uses of AMH as a predictive marker of menopause onset, diagnostic tool for polycystic ovary syndrome, and assessment of ovarian function before and after gynecologic surgeries or gonadotoxic agents such as chemotherapy have been investigated. Serum AMH levels can also be affected by environmental and genetic factors; thus, the effects of factors that may alter AMH test results should be considered. This review summarizes the findings of recent studies focusing on the clinical application of AMH and factors that influence the AMH level and opinions on the use of the AMH level to assess the probability of conception before reproductive life planning as a "fertility test. "

show abstract

Section: Use As a Marker For Predicting Age At Menopausementioning

confidence: 99%

Clinical application of serum anti-Müllerian hormone in women

Choe

Cho

2019

Clin Exp Reprod Med

View full text Add to dashboard Cite

show abstract

“…Menopause occurs when the number of remaining follicles falls below a critical threshold and the ovaries are no longer able to generate mature oocytes or maintain a menstrual cycle. 17 It appears that the end of natural fertility occurs at some point, approximately 10 years, before this point, though the ovaries maintain normal hormone secretion until 3-4 years before the menopausal transition. 3,17 Several studies have suggested that using AMH in addition to age can possibly predict timing of menopause in late reproductive-age women.…”

Section: Amhmentioning

confidence: 99%

“…17 It appears that the end of natural fertility occurs at some point, approximately 10 years, before this point, though the ovaries maintain normal hormone secretion until 3-4 years before the menopausal transition. 3,17 Several studies have suggested that using AMH in addition to age can possibly predict timing of menopause in late reproductive-age women. 2,17 However, other studies have suggested that these predictions may be too broad and less accurate at the extremes of age of menopause, limiting their clinical utility.…”

Section: Amhmentioning

confidence: 99%

“…3,17 Several studies have suggested that using AMH in addition to age can possibly predict timing of menopause in late reproductive-age women. 2,17 However, other studies have suggested that these predictions may be too broad and less accurate at the extremes of age of menopause, limiting their clinical utility. 2,17 Depmann and colleagues recently published a meta-analysis using data from 2596 women from several different countries to create models assessing time to early menopause and time to late menopause.…”

Section: Amhmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian Reserve Testing: A Review of the Options, Their Applications, and Their Limitations

Ulrich

Marsh

2019

Clinical Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Ovarian reserve refers to the number of oocytes remaining in a woman’s ovaries that have the potential to yield a pregnancy. This is a concept based on the fact that the number of oocytes within a woman’s ovaries and her ability to achieve pregnancy decline over time. There are 2 overlapping but distinct interpretations and utilizations of ovarian reserve testing (ORT)—biological and clinical. Given the increasing incorporation of ORT into clinical practice, care must be taken to ensure that patients and providers understand the limitations affecting ORT interpretation. Here, we will review commonly used tests of ovarian reserve and offer guidance on interpretation (biology) and application (clinical practice) of results.

show abstract

“…Repeated surgery for OMA has a higher risk of complications compared with primary endometrioma (68), and accumulation of postoperative adhesions over a lifetime may affect future fertility. Moreover, low AMH levels following surgery are predictive of earlier menopause and a shorter reproductive lifespan (69,70).…”

Section: Impact Of Endometrioma and Its Excision On Spontaneous Concementioning

confidence: 99%

Effect of endometrioma and its surgical excision on fertility (Review)

Jiang

Nie

2020

Exp Ther Med

View full text Add to dashboard Cite

Endometrioma is the cystic lesion of ovaries originating from endometrial glands and stroma; it is identified in 17-44% of patients with endometriosis. Numerous existing studies have reported the association between endometrioma and infertility. However, an absolute cause-effect association requires further confirmation. Available evidence has suggested that ovarian reserve may be impaired by spatial occupation influences, local reaction or both, affecting the reproductive health of females. Given the increased focus on the pathophysiological mechanisms of endometrioma, surgical excision has commonly been considered to avoid further ovarian damage. However, the potential adverse effect of this surgery on the ovarian reserve has recently become a focal point. Whether or not surgical excision can facilitate subsequent conception in young females planning to be pregnant is controversial. As shown in the present review on the effects of endometrioma and its removal in females requiring assisted reproductive technology, prior surgery for endometrioma may not improve assisted fertility results and may further decrease the number of oocytes retrieved in the affected females. Subsequent studies are needed to ascertain the optimal management of infertility in the setting of endometriomas.

show abstract

Does AMH Relate to Timing of Menopause? Results of an Individual Patient Data Meta-Analysis

Abstract: AMH was a significant predictor of TTM and especially of time to early menopause. However, individual predictions of age at menopause demonstrated a limited precision, particularly when concerning early age at menopause, making clinical application troublesome.

Cited by 70 publications

References 19 publications

Clinical application of serum anti-Müllerian hormone in women

Clinical application of serum anti-Müllerian hormone in women

Ovarian Reserve Testing: A Review of the Options, Their Applications, and Their Limitations

Effect of endometrioma and its surgical excision on fertility (Review)

Contact Info

Product

Resources

About