Comparative efficacy of a 12 week yoga-based lifestyle intervention and dietary intervention on adipokines, inflammation, and oxidative stress in adults with metabolic syndrome: a randomized controlled trial

Abstract

The present randomized controlled trial (RCT) evaluated the comparative efficacy of 12 week yoga-based lifestyle intervention (YBLI) and dietary intervention (DI) alone on adipokines, inflammation, and oxidative stress in Indian adults with metabolic syndrome (Met S). A parallel, two arm, RCT was conducted in Integral Health Clinic (IHC), All India Institute of Medical Sciences, India from 2012 to 2014. IHC is an outpatient facility conducting YBLI programs for prevention and management of chronic diseases. Two hundred sixty men and women (20-45 years) visiting the outpatient department of a tertiary care hospital were diagnosed with Met S and randomized 1:1 to receive 12 week YBLI (n = 130) or DI (n = 130). Primary outcomes were change in plasma levels of adipokines (leptin, adiponectin, and leptin:adiponectin ratio), markers of inflammation (tumor necrosis factor [TNF]-α, interleukin [IL]-6), markers of oxidative stress (thiobarbituric acid reactive substances [TBARS], 8-hydroxy-2'-deoxyguanosine [8-OHdG], and superoxide dismutase [SOD]) measured at baseline, 2 weeks, and 12 weeks. YBLI group showed a significant decrease in leptin, leptin:adiponectin ratio, IL-6, 8-OHdG, and TBARS levels, whereas there was a significant increase in adiponectin and SOD levels. No significant changes were noticed in DI alone group. YBLI showed significantly greater reduction in TBARS levels than in DI group, suggestive of reduced oxidative stress in adults with Met S. A 12 week YBLI had a positive impact on oxidative stress versus DI alone in adults with Met S.

Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis

“…Moreover, the yoga intervention had a positive impact on inflammatory response (reduction in IL-6) as well as antioxidant defense system (increase in SOD). 122 Furthermore, annual rates of change (Δ) in dairy calcium and phosphorus intake were inversely related to HDL-C dyslipidemia and MetS incidents, while Δ dairy fat was positively associated with incidence of hypertriglyceridemia and HDL-C dyslipidemia and MetS incidence. 123 It was also shown that dietary intervention by the intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) were associated with a lower risk of cardiovascular disease (CVD) incidence and death, whereas saturated fatty acids (SFA) and transfat intakes were associated with a higher risk of CVD.…”

The effect of yoga practice on glycemic control and other health parameters in the prediabetic state: A systematic review and meta-analysis

“…Approximately 50% of studies [49, 66–70] and the first author from three studies that were conducted in other countries [71–73], were of Indian origin. Because yoga is centered part of Indian tradition and culture, the intervention would be more effective in this nation.…”

The effects of exercise and low-calorie diets compared with low-calorie diets alone on health: a protocol for systematic reviews and meta-analyses of controlled clinical trials

“…A number of clinical trials have revealed that subjects show a significant weight loss and reduction in energy intake during an exercise intervention, while others have shown less reduction in body weight due to an increase in energy intake [30][31][32]. These conflicting results were also observed on other health outcomes such as bone health, appetite, and mood [33][34][35][36][37].…”