Increased Resting Heart Rate on Electrocardiogram Relative to In-office Pulse Rate Indicates Cardiac Overload: The J-HOP Study

Oba, Yusuke; Hoshide, Satoshi; Kabutoya, Tomoyuki; Kario, Kazuomi

doi:10.1093/ajh/hpy102

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…The main limitation of our study is that both baseline and in-trial RHRs were measured using automated office BP measurement (AOBPM). Previous differences were found between the pulse rate assessed by the physician and the heart rate obtained via electrocardiography [ 22 ]. The method of RHR estimation in the current study was not verified against other methods.…”

Section: Discussionmentioning

confidence: 99%

Resting Heart Rate and Cardiovascular Outcomes during Intensive and Standard Blood Pressure Reduction: An Analysis from SPRINT Trial

Sobieraj

Siński

Lewandowski

2021

JCM

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The association between elevated resting heart rate (RHR) as a cardiovascular risk factor and lowering of systolic blood pressure (SBP) to currently recommended values remain unknown. Systolic Blood Pressure Intervention Trial (SPRINT) data obtained from the NHLBI were used to describe the relationship between RHR and SBP reduction to <120 mmHg compared to SBP reduction to <140 mmHg. The composite clinical endpoint (CE) was defined as myocardial infarction, acute coronary syndrome, decompensation of heart failure, stroke, or cardiovascular death. Increased RHR was associated with a higher CE risk compared with low RHR in both treatment arms. A more potent increase of risk for CE was observed in subjects who were allocated to the SBP < 120 mmHg treatment goal. A similar effect of intensive and standard blood pressure (BP) reduction (p for interaction, 0.826) was observed in subjects with RHR in the 5th quintile (hazard ratio, 0.78, with 95% confidence interval (CI), 0.55–1.11) and in other quintiles of baseline RHR (hazard ratio, 0.75, with 95% CI, 0.62–0.90). Lower in-trial than baseline RHR was associated with reduced CE risk (hazard ratio, 0.80, with 95% CI, 0.66–0.98). We concluded that elevated RHR remains an essential risk factor independent of SBP reduction.

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Section: Discussionmentioning

confidence: 99%

Resting Heart Rate and Cardiovascular Outcomes during Intensive and Standard Blood Pressure Reduction: An Analysis from SPRINT Trial

Sobieraj

Siński

Lewandowski

2021

JCM

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“…Heart rate is an important indicator that is easily accessible and does not require advanced technical equipment. High heart rate is associated with increased CV events, both in the general human population and in people with CV risk factors [3] . In the Framingham Study, heart rate was found to be associated with mortality in men and women who are patients with hypertension [4] .…”

Section: Introductionmentioning

confidence: 99%

Association of Heart Rate with Global Left Ventricular Longitudinal Strain and Left Atrium Structural and Functional Changes in Hypertensive Patients with Normal Left Ventricular Ejection Fraction (A Speckle Tracking Study)

Emre

Özderya

Hancı

et al. 2023

Preprint

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Background: The structure and functions of the left heart cavities have important prognostic value in heart diseases and heart rate control is among the important treatment goals. Objectives: In this study, we investigated the effects of heart rate on left heart structure and functions in hypertension patients with normal left ventricular systolic function. Methods: This is a single-center, prospective, observational (case-control) study. One hundred fifty-three patients were included in the study. The patients were divided into two groups according to their heart rate (70 beats/min and below and above 70 beats/min). Left ventricular and atrial strain analyses were performed in echocardiographic evaluation. Results: Patients with a resting heart rate of 70 beats/min or less were named group-1(64.2±19), patients with a resting heart rate above 70 beats/min were named group-2(79.1±6.8). Left atrial maximum volüm (60.8±15.5 ml vs. 52.9±16.3 ml p:0.007), left atrial minimum volüm(28.8±9.5 vs. 22.6±7.9 p<0.001), left atrial emptying fraction (52.8±8.5% vs 56.1±8.5% p:0.035), left atrial expansion index (1.19±0.44 vs 1.36±0.47 p:0.044), pLASRcd(-1.3±0.38 vs -1.5±0.61 p:0.031), GLS(-19.3±3 vs. -18.2±2.7 p:0.07) showed difference between group-1 and group-2, respectively. In the multivariable regression analysis, beta-bloker(OR:0.291, 95% CI 0.105-0.810, p:0.018), mean high diastolic blood pressure(OR:1.054, 95% CI 1.009-1.101, p:0.018), left atrial minimum volüme (OR:0.870, 95% Cl 0.809-0.938, p<0.001), S’ (OR:10.6, 95% CI 1.1-104, p:0.041), left atrial expansion index(OR:0.870, 95% CI 0.809-0.930, p<0.033) were determined as independent predictors of high resting heart rate. Conclusions: Heart rate control emerges as an important goal in patients with hypertension and preserved left ventricular systolic function. Mortality and morbidity can also be improved by the positive effect of heart rate control on GLS.

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“…Heart rate is an important indicator that is easily accessible and does not require advanced technical equipment. High heart rate is associated with increased CV events, both in the general human population and in people with CV risk factors [3]. In the Framingham Study, heart rate was found to be associated with mortality in men and women who are patients with HT [4].…”

Section: Introductionmentioning

confidence: 99%

Association of Heart Rate with Left Ventricular and Left Atrial Functions in Hypertensive Patients with Normal Left Ventricular Ejection Fraction (A Speckle Tracking Study)

Emre

Özderya

Hancı

et al. 2022

Preprint

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Purpose The structure and functions of the left heart cavities have important prognostic value in heart diseases and heart rate control is among the important treatment goals. In this study, we investigated the effects of heart rate on left heart structure and functions in hypertension patients with normal left ventricular systolic function. Method One-hundred-fifty-three patients were included in the study. The patients were divided into two groups according to their heart rate(70 beats/min and below and above 70 beats/min). Left ventricular and atrial strain analyses were performed in echocardiographic evaluation. Results Patients with a resting heart rate of 70 or less were named group-1(64.2±19), patients with a resting heart rate above 70 were named group-2(79.1±6.8). Left atrial max volüm (60.8±15.5 vs 52.9±16.3 p:0.007), left atrial min volüm(28.8±9.5 vs 22.6±7.9 p < 0.001), left atrial emptying fraction%(52.8±8.5 vs 56.1±8.5 p:0.035), left atrial expansion index (1.19±0.44 vs 1.36±0.47 p:0.044), GLSReLA(-1.3±0.38 vs -1.5±0.61 p:0.031), GLS(-19.3±3 vs. -18.2±2.7 p:0.07) showed difference between group-1 and group-2, respectively. In the multivariable regression analysis, beta-bloker(OR:0.291, 95% CI 0.105–0.810, p:0.018), mean high diastolic blood pressure(OR:1.054, 95% CI 1.009–1.101, p:0.018), left atrial min volume( OR:0.870, 95% Cl 0.809–0.938, p < 0.001), Sm(OR:10.6, 95% CI 1.1–104, p:0.041), left atrial expansion index(OR:0.870, 95% CI 0.809–0.930, p < 0.033) were determined as independent predictors of high resting heart rate. Conclusions Heart rate control emerges as an important goal in patients with hypertension and preserved left ventricular systolic function. Mortality and morbidity can also be improved by the positive effect of heart rate control on GLS.

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Increased Resting Heart Rate on Electrocardiogram Relative to In-office Pulse Rate Indicates Cardiac Overload: The J-HOP Study

Abstract: A decreased delta HR was positively associated with the BNP level and LVMI. Without the requirement of a special technique, this evaluation might indicate potential cardiac overload and provide a clinical sign related to heart failure.

Cited by 7 publications

References 34 publications

Resting Heart Rate and Cardiovascular Outcomes during Intensive and Standard Blood Pressure Reduction: An Analysis from SPRINT Trial

Resting Heart Rate and Cardiovascular Outcomes during Intensive and Standard Blood Pressure Reduction: An Analysis from SPRINT Trial

Association of Heart Rate with Global Left Ventricular Longitudinal Strain and Left Atrium Structural and Functional Changes in Hypertensive Patients with Normal Left Ventricular Ejection Fraction (A Speckle Tracking Study)

Association of Heart Rate with Left Ventricular and Left Atrial Functions in Hypertensive Patients with Normal Left Ventricular Ejection Fraction (A Speckle Tracking Study)

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