Prospective Serial FDG PET/CT During Treatment of Extrapulmonary Tuberculosis in HIV-Infected Patients

Martin, Charlotte; Castaigne, Cathérine; Vierasu, Irina; García, C.; Wyndham-Thomas, Chloé; Wit, Stéphane De

doi:10.1097/rlu.0000000000002187

Cited by 15 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18F-fluorodeoxyglucose Positron Emission Tomography (18F-FDG-PET) is not routinely used; while it can identify sites of active inflammatory disease, it cannot differentiate GUT from cancer [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Genitourinary Tuberculosis: A Comprehensive Review of a Neglected Manifestation in Low-Endemic Countries

et al. 2021

View full text Add to dashboard Cite

Genitourinary tuberculosis (GUTB) represents a disease often underestimated by urological specialists, particularly in settings such as the European one, where the pathology is less frequent. Similar to other uncommon diseases at these latitudes, GUTB is a neglected clinical problem. In this light, the aim of this review is to give a comprehensive overview of GUTB in order to provide a useful tool for urologists who seldomly manage this disease. A non-systematic review of genitourinary tuberculosis was performed on relevant articles published from January 1990 to July 2021 using PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. GUTB represents up to a quarter of extrapulmonary tuberculosis (EPTB) cases. Diagnostic, therapeutic and surgical work-up have been deeply reviewed and summarized. The mass migration of refugees to Europe as well as the ease of international travel is gradually leading to an upsurge in urological diseases such as GUTB, which were previously only rarely encountered in some European countries. The poor TB knowledge of European urologists should be improved through medical education courses, webinars or telematic means.

show abstract

Section: Resultsmentioning

confidence: 99%

Genitourinary Tuberculosis: A Comprehensive Review of a Neglected Manifestation in Low-Endemic Countries

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It should be noted, however, that detection of extrapulmonary lesions may be particularly useful in such patients since they could be due to a variety of infectious or noninfectious complications of HIV/AIDS. The role of 18 F-FDG PET/CT in HIV-infected patients was recently addressed in a small study of 18 HIV/TB patients [15]. After 2 months of treatment, 78% of patients had a significant metabolic response.…”

Section: Discussionmentioning

confidence: 99%

“…Positron emission tomography (PET) using 2-deoxy-2-[fluorine -18] fluoro-D-glucose ( 18 F-FDG) provides functional information on sites of active inflammation and, in combination with CT data, delivers functional and anatomical information in a single scan [8,9]. Preliminary studies on TB in macaques [10][11][12][13] and humans [14][15][16][17][18][19] employing 18 F-FDG PET/CT as a research tool have suggested that it might be of clinical value for localisation of disease sites and assessment of treatment response. Currently there are several ongoing research studies on the application of PET/CT as a biomarker of treatment response in new drug combination trials and for insight into pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Sequential 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan findings in patients with extrapulmonary tuberculosis during the course of treatment—a prospective observational study

Bomanji¹,

Sharma

Mittal

et al. 2020

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Background:Preliminary studies of Tuberculosis (TB) in macaques and humans using 18 F-FDG Positron Emission Tomography (PET) imaging as a research tool suggest its usefulness in localising disease sites and as a clinical biomarker. Sequential serial scans in patients with extrapulmonary TB (EPTB) could provide information on the usefulness of PET-CT for monitoring response to therapy and defining cure. Patients and Methods:HIV-negative adults with EPTB from 8 sites across 6 countries had three 18 F-FDG PET/CT scans: (i) within 2 weeks of enrolment, (ii) at 2 months into TB treatment and (iii) at end of ATT treatment.Scanning was performed according to the EANM guidelines. 18 F-FDG PET/CT scans were performed 60±10 min after intravenous injection of 2.5-5.0 MBq/kg of 18 F-FDG. Findings:147 patients with EPTB underwent three sequential scans. A progressive reduction over time of both the number of active sites and the uptake level (SUVmax) at these sites was seen. At the end of WHO recommended treatment: 53/147 (36.0%) patients had negative PET/CT scans, and 94/147 (63.9%) patients remained PET/CT positive, of which twelve patients had developed MDR TB. One died of brain tuberculoma.

show abstract

“…On autopsy, multiple tuberculous lesions may be detected throughout the body in organs such as the lungs, liver, spleen, brain and others. There are many studies and case reports relevant to PET/CT utility that reveal the diagnostic and the thera-peutic response evaluation in tuberculosis patients [9][10][11][12][13][14][15][16][17][18][19][20][21]. These studies are about the organ involvement of mycobacterium tuberculosis infection while none of these papers have presented data concerning miliary tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic utility of PET/CT in a patient with miliary tuberculosis

Tetikkurt

Inci²,

Yanardag³

2019

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

A 63-year-old male presented with loss of appetite, subfebrile fever, swelling of the right hand and dyspnea on exertion for three months. Past medical history revealed methotrexate treatment of six months for rheumatoid arthritis. Chest radiography and computed tomography (CT) revealed diffuse miliary nodules. PET/CT scan demonstrated diffuse FDG uptake in both lungs, in the spleen, in the right hand, the mediastinal and the axillary lymph nodes. MR of the right hand showed inflammatory arthritis. Histopathology of the right hand tru-cut biopsy revealed degenerative changes. Culture of the hand biopsy tissue was positive for mycobacterium tuberculosis. PET/CT may determine the biopsy and the sampling sites for the early diagnosis of patients with suspected miliary tuberculosis where lesion identification on other modalities may be difficult or unfeasible. High sensitivity for inflammatory diseases makes PET/CT a useful diagnostic utility for enabling early diagnosis in miliary tuberculosis which is a diagnostic predicament.

show abstract

Prospective Serial FDG PET/CT During Treatment of Extrapulmonary Tuberculosis in HIV-Infected Patients

Abstract: In difficult-to-treat entities such as extrapulmonary TB in HIV patients, FDG PET/CT is a potential tool in monitoring TB treatment response and should be explored in larger studies.

Cited by 15 publications

References 26 publications

Genitourinary Tuberculosis: A Comprehensive Review of a Neglected Manifestation in Low-Endemic Countries

Genitourinary Tuberculosis: A Comprehensive Review of a Neglected Manifestation in Low-Endemic Countries

Sequential 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan findings in patients with extrapulmonary tuberculosis during the course of treatment—a prospective observational study

Diagnostic utility of PET/CT in a patient with miliary tuberculosis

Contact Info

Product

Resources

About