Arzneimitteltherapiesicherheit bei Kindern

Neubert, Antje; Rascher, Wolfgang

doi:10.1007/s00103-018-2792-1

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…The present study was part of the KiDSafe project. 23 We collected data from all patients who were nonelectively admitted to the pediatric department including pediatric intensive care excluding pediatric oncology and neonatology. Data assessment and evaluation was performed anonymously.…”

Section: Setting and Patientsmentioning

confidence: 99%

Adverse Drug Reactions at Nonelective Hospital Admission in Children and Adolescents: Comparison of 4 Causality Assessment Methods

et al. 2022

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ObjectivesThis study aimed to compare assessment methods to determine adverse drug reactions (ADRs) at nonelective hospital admission in pediatric patients, to investigate the interrater reliability of assessment methods in pediatric care, and to analyze symptoms related to ADRs and (suicidal) drug intoxications.MethodsFor 1 year, the medical records of nonelective patients admitted to a university pediatric department were evaluated for potential ADRs using 4 assessments methods by 1 experienced rater. Krippendorff α was calculated from a sample of 14 patients evaluated by 4 experienced raters to determine interrater reliability.ResultsIn 1831 nonelective hospital admissions, 63.4% (1161 of 1831) of patients had received at least one drug before admission. We found a potential causal relationship between drugs and symptoms documented at admission and thus potential ADRs according to Naranjo in 23.3% (271 of 1161) of those patients, World Health Organization - Uppsala Monitoring Centre (WHO-UMC) in 22.5% (261 of 1161), Koh in 21.7% (252 of 1161), and Begaud in 16.5% (192 of 1161). The probability rating of the potential causal relationships varied considerably between the methods (Naranjo-Begaud, P < 0.01; Naranjo-Koh, P < 0.001; Koh-Begaud, P < 0.01; Begaud-WHO-UMC, P < 0.01). Acceptable interrater reliability (α ≥ 0.667) was only obtained for WHO-UMC (α = 0.7092). The most frequently identified definite ADR was sedation in 1.5% of all nonelective patients with medication before hospital admission. In 1.2% (22 of 1831) of all nonelective admissions, we found drug intoxications with suicidal intent.ConclusionsThe assessment methods showed a high variability in the determination of a potential causal relationship between drug and documented symptom, in the classification of the probability of ADRs, and suboptimal interrater reliability. Thus, their feasibility in pediatric patients is limited.

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Section: Setting and Patientsmentioning

confidence: 99%

Adverse Drug Reactions at Nonelective Hospital Admission in Children and Adolescents: Comparison of 4 Causality Assessment Methods

et al. 2022

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“…Die im Rahmen des KiDSafe-Projekts angebotenen Qualitätszirkel zu verschiedenen Themen der Arzneimitteltherapie wurden von den Ärztinnen und Ärzten sehr gut angenommen. Knapp zwei Drittel der Teilnehmenden gaben an, dass sich durch den Besuch der Seminare die eigene Sicherheit bei der Medikamentenverordnung verändert hat (KiDSafe, unveröffentlichte Daten; Neubert et al 2019).…”

Section: Fort-und Weiterbildungunclassified

Arzneimittelversorgung von Kindern

Toni

Moritz

Zahn

et al. 2022

Arzneimittel-Kompass 2022

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“…The lack of age-appropriate medicinal products in the market is closely related to high off-label use [20]. Age, health condition, and individual abilities play a significant role in selecting the appropriate dosage form [21].…”

Section: Evaluation Of the Prototype Pdismentioning

confidence: 99%

Development and Evaluation of a Web-Based Paediatric Drug Information System for Germany

et al. 2021

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Background: Off-label use is frequent in paediatrics but that does not necessarily mean that the risk-benefit ratio is negative. Nevertheless, evidence-based data is essential for safe drug therapy. In Germany, there is no publicly available compendium providing transparent, evidence-based information for paediatric pharmacotherapy to date. This work describes the development of a web-based paediatric drug information system (PDIS) for Germany and its evaluation by health care professionals (HCP). Methods: Since 2012, a PDIS is being developed by the authors and is supported by the Federal Ministry of Health since 2016. Dosing recommendations were established based on systematic literature reviews and subsequent evaluation by clinical experts. The prototype was evaluated by HCP. Based on the results, the further development was concluded. Results: 92% of HCP believed that the PDIS could improve the quality of prescribing, as currently available information is deficient. Besides the license and formulations, dosing recommendations were the most relevant modules. A dosage calculator was the most wanted improvement. To facilitate sustainability of future development, a collaboration with the Dutch Kinderformularium was established. As of 2021, the database will be available to German HCP. Conclusion: The fundamentals for a German PDIS were established, and vital steps were taken towards successful continuation.

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Arzneimitteltherapiesicherheit bei Kindern

Cited by 7 publications

References 41 publications

Adverse Drug Reactions at Nonelective Hospital Admission in Children and Adolescents: Comparison of 4 Causality Assessment Methods

Adverse Drug Reactions at Nonelective Hospital Admission in Children and Adolescents: Comparison of 4 Causality Assessment Methods

Arzneimittelversorgung von Kindern

Development and Evaluation of a Web-Based Paediatric Drug Information System for Germany

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