Tracheobronchial involvement of mantle cell lymphoma

Abstract

Mantle cell lymphoma (MCL) is a rare type of B‐cell non‐Hodgkin’s lymphoma that commonly affects extranodal sites; however, tracheobronchial involvement is rare. We report the case of a 65‐year‐old male who presented with cough and dyspnoea. A chest computed tomography (CT) revealed irregular wall thickening of the trachea and bilateral bronchi and bilateral bronchiectasis. A bronchoscopy revealed a diffuse irregular surface of the tracheal and bilateral bronchial mucosa and polyposis‐like lesions. He was diagnosed with MCL based on an endobronchial biopsy, and then, the diagnosis was confirmed with a biopsy of the fluorodeoxyglucose (FDG)‐avid nasal mucosal soft tissue.

Mantle cell lymphoma with endobronchial involvement: A case report

“…MCL is a kind of B cell aggressive NHL with the feature of hyperplasia of B-cells. These B-cells is a subset arising from antigen-experienced B cells resembling those found in the follicular mantle zones [ 1 ]. Immunohistochemical staining was positive for Bcl-2, CD5, CD19, CD20 and cyclin D1 and negative for Bcl-6, CD10 and CD23[ 9 ].…”

“…Although MCL was more likely to have extranodal involvement, endobronchial involvement is uncommon[ 5 , 6 ]. As far as we know, only 5 cases of MCL with tracheobronchial involvement have been represented in the literature (Table 1 )[ 1 , 2 , 10 - 12 ]. Lymphoma with endobronchial involvement is divided into two types: Diffuse submucosal infiltration (type I) and localized solitary mass (type II)[ 13 ].…”

“…MCL is one of the most difficult-to-treat B-cell lymphomas[ 1 ]. In previously untreated patients, conventional chemotherapy is the most common treatment and the remission rates is high.…”

“…Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin's lymphoma (NHL). Over expression of cyclin D1 and reciprocal chromosomal translocation t(11;14)(q13;q32) are the distinguishing features of MCL[ 1 , 2 ]. MCL represents approximately 4%-6% of all NHL[ 3 , 4 ].…”

Endoscopic airway manifestations in a pediatric patient with activated PI3K‐delta syndrome

“…There are case reports of certain types of B-cell lymphomas inclusive of mantle cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue,that present as tiny nodules along the airways 4. However such lymphomas are rare and airway findings have not been reported in the pediatric population 5. We present a case of APDS with diffuse airway involvement in a pediatric patient, in which flexible bronchoscopy was crucial to determining her diagnosis.…”