“…81,82 Nevertheless, ALDH1L2 is highly expressed and presents as an independent prognostic factor for overall survival in melanoma, PDAC, and CRC. 77,78,83 Depletion of ALDH1L2 markedly decreases the NADPH/NADP + and GSH/GSSG ratios, reduces the circulating tumor cells in blood and alleviates the metastatic burden. 77,83,84 In addition, the expression of ALDH1L2 is upregulated by some certain drugs, such as thapsigargin and tunicamycin, endoplasmic reticulum stress inducers in immortalized human B cells, 85 mitotane, an adjuvant monotherapy used for treating adrenocortical carcinoma, 86 and the indomethacin, an anti-inflammatory agent in breast cancer cells.…”