A closely-related clade of globally distributed bloom-forming cyanobacteria within the Nostocales

Driscoll, Connor B.; Meyer, Kevin A.; Šulčius, Sigitas; Brown, Nathan; Dick, Gregory J.; Cao, Huansheng; Gasiūnas, Giedrius; Timinskas, Albertas; Yin, Yanbin; Landry, Zachary C.; Otten, Timothy G.; Davis, Timothy W.; Watson, Susan B.; Dreher, Theo W.

doi:10.1016/j.hal.2018.05.009

Cited by 33 publications

(47 citation statements)

References 136 publications

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“…The Anabaena, Aphanizomenon and Dolichospermum genera form a phylogenetically closely related genera complex (ADA clade) of filamentous, nitrogen-fixing cyanobacteria, which is known for the production of an array of toxins [5,6]. Cyanobacteria assigned to the genus Anabaena have been reported to produce more different toxins than any other cyanobacteria group, including hepatotoxic microcystin [7,8], cytotoxic cylindrospermopsin [9], neurotoxic anatoxin-a [10], guanitoxin [11,12], and saxitoxin [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Cyanobacteria assigned to the genus Anabaena have been reported to produce more different toxins than any other cyanobacteria group, including hepatotoxic microcystin [7,8], cytotoxic cylindrospermopsin [9], neurotoxic anatoxin-a [10], guanitoxin [11,12], and saxitoxin [13,14]. Some Dolichospermum and Aphanizomenon strains also produce geosmin, a volatile odorous metabolite, which frequently causes taste and odor problems in drinking water production [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Benthic and planktonic strains of Anabaena were shown to constitute phylogenetically separate entities a decade ago despite their morphological similarity and planktonic strains were reclassified as a new genus, Dolichospermum [17]. Aphanizomenon is morphologically distinct from Anabaena and Dolichospermum [18], but all these three genera are intermixed phylogenetically in what has been called the ADA clade [6,19]. Anabaena and Aphanizomenon strains are also found outside the ADA clade, and some of these strains have been reassigned to other genera, for instance Sphaerospermum and Chrysosporum [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Although cyanobacterial natural products are studied intensively, the obscurity of nomenclature and taxonomy of these organisms makes it difficult to determine the genuine distribution of bioactive compounds in the taxa [23]. Two recent studies on 15 [6] and 17 ADA genomes [19] revealed an array of natural product BGCs and established four phylogenetic subgroups within the clade. These subgroups were proposed to represent four species in which toxin BGCs were sporadically present [6].…”

Section: Introductionmentioning

confidence: 99%

“…Two recent studies on 15 [6] and 17 ADA genomes [19] revealed an array of natural product BGCs and established four phylogenetic subgroups within the clade. These subgroups were proposed to represent four species in which toxin BGCs were sporadically present [6]. However, the number of genomes was insufficient to determine which traits would define these species and these subgroups were not consistent with division to Anabaena, Dolichospermum and Aphanizomenon genera.…”

Section: Introductionmentioning

confidence: 99%

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Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

Österholm

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et al. 2020

Toxins

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Cyanobacteria produce an array of toxins that pose serious health risks to humans and animals. The closely related diazotrophic genera, Anabaena, Dolichospermum and Aphanizomenon, frequently form poisonous blooms in lakes and brackish waters around the world. These genera form a complex now termed the Anabaena, Dolichospermum and Aphanizomenon (ADA) clade and produce a greater array of toxins than any other cyanobacteria group. However, taxonomic confusion masks the distribution of toxin biosynthetic pathways in cyanobacteria. Here we obtained 11 new draft genomes to improve the understanding of toxin production in these genera. Comparison of secondary metabolite pathways in all available 31 genomes for these three genera suggests that the ability to produce microcystin, anatoxin-a, and saxitoxin is associated with specific subgroups. Each toxin gene cluster was concentrated or even limited to a certain subgroup within the ADA clade. Our results indicate that members of the ADA clade encode a variety of secondary metabolites following the phylogenetic clustering of constituent species. The newly sequenced members of the ADA clade show that phylogenetic separation of planktonic Dolichospermum and benthic Anabaena is not complete. This underscores the importance of taxonomic revision of Anabaena, Dolichospermum and Aphanizomenon genera to reflect current phylogenomic understanding.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

Österholm

Popin

Fewer

et al. 2020

Toxins

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First report about toxic cyanobacterial bloom occurrence in Lake Sevan, Armenia

et al. 2020

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Lake Sevan, Armenia, is the largest freshwater body in the Caucasus region. Cyanobacteria have become increasingly dominant in summer in Lake Sevan, reflecting the eutrophication of the lake and formed a massive bloom event in 2018. These recent observations mark the transition of this previously oligotrophic high mountain lake into an eutrophic lake with scum-forming cyanobacterial blooms. A bloom of Dolichospermum in July caused a sudden increase in chlorophyll-a concentrations up to, on average, 20 µg/L and a strong decrease in water transparency. The cyanobacterial genera Dolichospermum, Aphanizomenon, Anabaena, Cyanobium, and Synechococcus were detected by metagenomic analysis of the lake bacterioplankton. A qualitative and quantitative assessment of peptide-based secondary metabolites revealed the first detection of cyanotoxins in Lake Sevan. Ten types of microcystin congeners were found in Lake Sevan. The total concentration of microcystins in the phytoplankton varied from 0.34 to 2.49 µg/L. This first record of cyanotoxins in the largest lake in the Caucasus region calls for an urgent need for sustainable nutrient management and a systematic assessment of the ultimate causes that lead to the reoccurrence of scum-forming Cyanobacteria in this large Alpine lake.

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Mortality of Endangered Juvenile Lost River Suckers Associated with Cyanobacteria Blooms in Mesocosms in Upper Klamath Lake, Oregon

et al. 2020

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Unsustainably high mortality within the first 2 years of life prevents endangered Lost River Suckers Deltistes luxatus in Upper Klamath Lake, Oregon, from recruiting to spawning populations. Massive blooms of the cyanobacterium Aphanizomenon flos-aquae and their subsequent death and decay in the lake (bloom-crashes) are associated with high pH, low percent oxygen saturation, high total ammonia concentrations, and spikes in the cyanotoxin microcystin. Poor water quality within the lake is considered the most likely cause of juvenile sucker mortality, but mechanisms causing the high mortality are not known. We introduced PIT-tagged age-1 Lost River suckers into three continuously monitored mesocosms in Upper Klamath Lake to determine the timing of juvenile sucker mortality relative to pH, temperature, and dissolved oxygen. Mortality was inferred from a lack of movement detected on remote PIT tag detection equipment within each mesocosm. Mortality was compared among mesocosms and an indoor tank-held control group. We fitted time-varying Cox hazard models to test hypotheses about short-term and chronic effects of single

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A closely-related clade of globally distributed bloom-forming cyanobacteria within the Nostocales

Cited by 33 publications

References 136 publications

Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

Phylogenomic Analysis of Secondary Metabolism in the Toxic Cyanobacterial Genera Anabaena, Dolichospermum and Aphanizomenon

First report about toxic cyanobacterial bloom occurrence in Lake Sevan, Armenia

Mortality of Endangered Juvenile Lost River Suckers Associated with Cyanobacteria Blooms in Mesocosms in Upper Klamath Lake, Oregon

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