Effective antioxidant, antimicrobial and anticancer activities of essential oils of horticultural aromatic crops in northern Egypt

Elansary, Hosam O.; Abdelgaleil, Samir A. M.; Mahmoud, Eman A.; Yessoufou, Kowiyou; Elhindi, Khalid M.; El-Hendawy, Salah

doi:10.1186/s12906-018-2262-1

Cited by 76 publications

(65 citation statements)

References 58 publications

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“…Studies with Origanum officinale, a plant in the same family as C. angustifolia, showed high cytotoxicity to MCF-7 cell lines (IC 50 = 8.11 μg mL À 1 ), associated with the presence of pulegone in high concentration (77.5 %) in the essential oil. [8] Mentha pulegium essential oil, rich in pulegone (68.7 %), was tested in A549 cell lines by MTT assay, and low cytotoxicity was observed (IC 50 = 253.4 μg mL À 1 ) after 48 h of treatment, [9] which demonstrated the low activity of the main component to A549 cells and corroborated the results obtained in this study. Essential oils are a very complex mixture and should be considered that also the minor components with high cytotoxic activity identified could contribute to the cytotoxic activity observed.…”

Section: Effects Of Essential Oil On the Viability Of Cancer Cell Linessupporting

confidence: 84%

“…The MTS assay demonstrates that the essential oil is highly effective in breast cancer cell lines, with the lowest IC 50 obtained in this study. Studies with Origanum officinale , a plant in the same family as C. angustifolia , showed high cytotoxicity to MCF‐7 cell lines (IC 50 =8.11 μg mL −1 ), associated with the presence of pulegone in high concentration (77.5 %) in the essential oil . Mentha pulegium essential oil, rich in pulegone (68.7 %), was tested in A549 cell lines by MTT assay, and low cytotoxicity was observed (IC 50 =253.4 μg mL −1 ) after 48 h of treatment, which demonstrated the low activity of the main component to A549 cells and corroborated the results obtained in this study.…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxic Activity of Cunila angustifolia Essential Oil

Sousa

Morgan

Cesca

et al. 2020

Chemistry & Biodiversity

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The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC‐FID and GC‐MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF‐7) and skin melanoma (SK‐Mel‐28). The assay showed the highest selectivity, to MCF‐7 cell lines, with IC50 equal to 34.0 μg mL−1, low selectivity for SK‐Mel‐28 cell lines, with IC50 equal to 279.9 μg mL−1, and no mortality to A549 cell lines.

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Section: Effects Of Essential Oil On the Viability Of Cancer Cell Linessupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Cytotoxic Activity of Cunila angustifolia Essential Oil

Sousa

Morgan

Cesca

et al. 2020

Chemistry & Biodiversity

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“…where AB is the absorbance, and (AB 570nm ) C and (AB 570nm ) s are Abs.570 nm of control and sample, respectively. By plotting the percentage of viable cells against extract concentration, the IC 50 values were calculated in µg mL −1 using flow cytometry (FAC Scan, Becton Dickinson, Iowa, USA) as described in [2,33,56], and untreated cells were considered control.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

Malus baccata var. gracilis and Malus toringoides Bark Polyphenol Studies and Antioxidant, Antimicrobial and Anticancer Activities

et al. 2020

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Exploring new sources of polyphenols with biological activities that work against human diseases is the target of natural product studies. This study determined the polyphenol composition of the bark of Malus species M. baccata var. gracilis (Rehder) T.C.Ku and M. toringoides (Rehder) Hughes, using high-performance liquid chromatography with a diode-array detector (HPLC-DAD) analysis. The antiproliferative, cytotoxic, antioxidant and antimicrobial applications of these extracts, as well as the identified phenol, were studied. The HPLC-DAD analysis confirmed three polyphenols in the extracts out of the 21 screened compounds: protocatechuic acid, gallic acid, and catechin. The major constituents in M. baccata and M. toringoides were protocatechuic acid, at 3.16 and 7.15 mg 100 g−1 dry weight (DW), respectively, and catechin, at 5.55 and 6.80 mg 100 g−1 DW, respectively. M. baccata and M. toringoides bark extracts showed antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric-reducing antioxidant power (FRAP) assays, which were attributed to the dominance of protocatechuic acid. The highest antiproliferative and cytotoxic effects were against Jurkat cells. Against MCF-7 and Hela cells, there was necrotic cell accumulation in the early apoptotic as well as the late apoptotic phase. The bark extracts showed noticeable antibacterial effects against Listeria monocytogenes, Bacillus cereus, and Escherichia coli. Protocatechuic acid showed comparable results to bark extracts. There were antifungal effects against Aspergillus ochraceus, A. niger, and Candida albicans, and the activities were higher than the commercial reagent. M. baccata and M. toringoides could be considered as a new source of phenolic acids, including protocatechuic acid with anticancer, antibacterial antifungal, and antioxidant-promising effects.

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“…Furthermore, IC 50 values were obtained by plotting the percentage of cell viability against extract concentration and expressed in µg/mL. The IC 30 and IC 50 were determined in the apoptotic cell population (flow cytometry, FAC Scan, Becton Dickinson, Iowa, USA) following [1, 15,16]. Control cells were untreated with extracts or methanol standards.…”

Section: Anti-cancer Activitiesmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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Discovering new natural resources of polyphenols is the aim of many recent studies in the field of natural product research. This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The dominant compounds were: gentisic acid in M. rhodantha and M. spinosissima; chlorogenic acid in M. muehlenpfordtii, M. crucigera, and M. rhodantha; and caffeic acid in M. rhodantha, M. crucigera, and M. spinosissima. Stems of Mammillaria sp. showed antiproliferative effects against HeLa, MCF-7, and Jurkat cells. In HeLa and MCF-7 cells, the best antiproliferative activities were found in the treatments with M. rhodantha, M. spinosissima, and M. muehlenpfordtii. The apoptotic assay of M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed accumulation of necrotic cells in the early and late apoptotic phase. M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed the highest anti-oxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric reducing anti-oxidant power (FRAP) assays. M. rhodantha was the best source of antioxidants. Mammillaria sp. showed moderate anti-bacterial effects against bacteria and the highest effects were found using the extracts of M. rhodantha, M. spinosissima, M. crucigera and M. muehlenpfordtii against most bacteria. The anti-bacterial activities were attributed to other phenolic compounds (e.g., chlorogenic acid) than gentisic acid, which was not active against most bacteria. Mammillaria sp. could be considered to be an important natural source of phenolic acids with anti-cancer, anti-bacterial, and anti-oxidant activities.

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Effective antioxidant, antimicrobial and anticancer activities of essential oils of horticultural aromatic crops in northern Egypt

Cited by 76 publications

References 58 publications

Cytotoxic Activity of Cunila angustifolia Essential Oil

Cytotoxic Activity of Cunila angustifolia Essential Oil

Malus baccata var. gracilis and Malus toringoides Bark Polyphenol Studies and Antioxidant, Antimicrobial and Anticancer Activities

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

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