Long-term shedding of Canine alphaherpesvirus 1 in naturally infected newborn pups

Losurdo, Michele; Dowgier, Giulia; Lucente, Maria Stella; Cinone, Mario; Camero, Michele; Colaianni, Maria Loredana; Passantino, Giuseppe; Ventriglia, Gianluca; Buonavoglia, Domenico; Decaro, Nicola

doi:10.1016/j.rvsc.2018.07.001

Cited by 9 publications

(18 citation statements)

References 20 publications

(19 reference statements)

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“…Compared to our results, other researchers have reported various prevalence of CHV-1 using molecular assays. Using real-time PCR technique, Losurdo reported that not only CHV-1 developed a fatal systemic illness clinically and histologically, but also it could result in long-term shedding of the virus through the nasal and ocular secretions and the faeces [3]. So, infected puppies pose a threat for other animals in the colony.…”

Section: Discussionmentioning

confidence: 99%

“…Canine herpesvirus-1 (CHV-1), an alpha herpesvirus, is considered as a significant cause of neonatal deaths and reproductive problems in bitches with a widespread distribution [1][2][3]. In 1965, Carmichael et al described this pathogen for the first time [4].…”

Section: Introductionmentioning

confidence: 99%

“…CHV-1 infection causes various clinical presentations based on the age of infected animals [5]. Newborn puppies are susceptible to manifest an acute fatal generalized systemic illness which is characterized by progressive multifocal hemorrhagic necrosis in multiple organs [3,9,10] Mild subclinical infection or inapparent clinical illness is observed in puppies older than 3 weeks [11]. Adult domestic dogs can be clinically asymptomatic or display canine infectious respiratory disease complex and genital papulovesicular lesions [12].…”

Section: Introductionmentioning

confidence: 99%

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The first molecular detection of Canine herpesvirus-1 in reproductive specimens of adult dogs in Iran

Rezaei

Jajarmi

Alizadeh

et al. 2019

Preprint

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Background Canine herpesvirus-1 (CHV-1) is recognized to be enzootic in the dog population with a widespread distribution. This pathogen leads to a lethal generalized illness in newborn puppies and is associated with reproductive disorders. CHV-1 should be considered as an important pathogen of neonatal death and infertility; so, it appears to pose a threat for breeding kennels. Although serologic data point to the circulation of CHV-1 among dogs of Iran, not definitive diagnosis has been conducted based on the molecular assay. So, this research was done to detect the prevalence of CHV-1 in dogs of Kerman. In this study, the presence of CHV-1 in vaginal specimens and biopsies of the uterus of dogs referring to the Veterinary Hospital of Shahid Bahonar University of Kerman was determined. Samples were collected and evaluated using real-time PCR.Results Viral DNA was detected in 21 samples from a total of 140 (15%) collected samples which were related to 14 uterine samples (20%) and 7 (10%) vaginal specimens. The association of this virus with age, breed, housing, pregnancy and reproductive disorders was not significant.Conclusions This study is the first molecular detection of CHV-1 in reproductive samples of dogs in Iran. Considering the significant prevalence of this virus, it is necessary to carry out management measures in controlling and preventing this disease. Tracing CHV-1 requires further research on this virus in dogs of this region.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The first molecular detection of Canine herpesvirus-1 in reproductive specimens of adult dogs in Iran

Rezaei

Jajarmi

Alizadeh

et al. 2019

Preprint

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“…The virus is responsible for fetal death, abortion, mummification, or stillbirth in pregnant bitches [11]. Moreover, respiratory disease, ocular signs, and genital lesions are also documented [5, [12][13][14]. Lifelong latent infection is associated with localization of CHV-1 to nerve ganglia following recovery [1].…”

Section: Introductionmentioning

confidence: 99%

“…Kapil, 2015 demonstrated the shedding of CHV-1 in the vaginal canal during parturition as a risk factor for newborn puppies[23]. Long-term shedding of CHV-1 in neonatal puppies was documented by Losurdo et al in 2018[13]. Immunosuppression following administration of systemic prednisolone to the latently infected adult dogs can also reactive the virus[5].ConclusionsConsidering the results of this study, it is demonstrated that CHV-1 is present in the southeast of Iran.CHV-1 is common in farm and breeding kennels and could pose a threat.…”

mentioning

confidence: 99%

Detection of Canine herpesvirus 1 in the breeding kennel and farm dogs by Real-time PCR

Rezaei¹,

Jajarmi²,

Kamani³

et al. 2020

Preprint

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Background: Canine herpesvirus 1 (CHV-1) is known as a causal agent of death in newborn puppies and fertility problems in adults with a widespread distribution. There has been an increasing concern among dog breeders in Iran regarding CHV-1. This study is the first molecular detection of CHV-1 in breeding kennels and farm dogs in Iran using real-time PCR and investigation of various predisposing factors. Results: A total of 63 vaginal samples collected from 47 breeding kennels and 16 farm dogs were evaluated. In general, 21 out of 63 (33.3%) of vaginal samples were CHV-1-positive. The percentage of infection was higher in farm dogs, which was statistically significant. There was no significant association regarding other probable predisposing factors, including age, breed, pregnancy, and reproductive disorders. Conclusions: Considering the results of this study, CHV-1 is common in farm and breeding kennels and could pose a threat. Further studies are required to better understanding the distribution of the virus within Iran to advise dog breeders to more appropriate measures for management of CHV-1.

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Prevalence of canine herpesvirus 1 and associated risk factors among bitches in Iranian breeding kennels and farms

Rezaei,

Jajarmi,

Kamani

et al. 2023

Veterinary Medicine & Sci

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BackgroundCanine herpesvirus 1 (CHV‐1) is an important cause of death in newborn puppies and of fertility problems in adult dogs. Identification of risk factors may help to reduce infection rates and alleviate concerns for dog owners and breeders. This study was designed to screen for CHV‐1 infection in bitches of breeding kennels and farms in Iran and relate this to possible risk factors.MethodsA total of 63 vaginal samples were collected from dogs in 5 breeding kennels (n = 47) and from 7 farms (n = 16). Real‐time polymerase chain reaction was used to detect the CHV‐1 specific glycoprotein B (gB) gene. Prevalence rates were evaluated in relation to various risk factors, including region, housing, vaccination, deworming, pregnancy, reproductive problems, number of dogs living together and hygiene conditions.ResultsIn total, 21 (33.3%) of 63 vaginal samples were positive for CHV‐1 DNA. The prevalence rate in farms (7/16; 43.7%) was higher than in kennels (14/47; 29.7%). No association was found between CHV‐1 prevalence and potential risk factors.ConclusionsCHV‐1 is highly prevalent in dogs in Iranian farms and kennels. Since the CHV1 vaccine is unlicensed in Iran, effective management strategies are essential to reduce the consequences of this pathogen.

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Long-term shedding of Canine alphaherpesvirus 1 in naturally infected newborn pups

Cited by 9 publications

References 20 publications

The first molecular detection of Canine herpesvirus-1 in reproductive specimens of adult dogs in Iran

The first molecular detection of Canine herpesvirus-1 in reproductive specimens of adult dogs in Iran

Detection of Canine herpesvirus 1 in the breeding kennel and farm dogs by Real-time PCR

Prevalence of canine herpesvirus 1 and associated risk factors among bitches in Iranian breeding kennels and farms

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