30 μg de clonidine en intrathécal prolonge l'analgésie du travail, mais augmente l'incidence des hypotensions et des anomalies du rythme cardiaque fœtal

Amor, M. Belhadj; Draief, A.; Ouezini, R.; Dhahri, S.; Jebali, A.; Lamine, Khaled; Ferjani, Mustapha

doi:10.1016/j.annfar.2007.09.009

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…Dexmedetomidine, as an adjuvant, can prolong the duration of analgesia of a local anesthetic in spinal anesthesia [8]. Hemodynamic effects such as bradycardia or hypotension of the α2 adrenergic agonists, as well as their effects on the fetal outcome, depend on the dose [9][10][11]. The use of intrathecal adjuvants, with doses that the literature has shown to be safe, did not affect neonates.…”

Section: Introductionmentioning

confidence: 99%

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Coviello

Iacovazzo

D’Abrunzo

et al. 2022

JCM

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Spinal anesthesia is the best choice for caesarean delivery. This technique is characterized by a complete and predictable nerve block with a fast onset and few complications. Several intrathecal adjuvants are used in order to improve the quality and duration of anesthesia and reduce its side effects. Sixty-two patients who underwent caesarean delivery under spinal anesthesia were included in this medical records review. In this retrospective study, after adopting exclusion criteria, we assessed 24 patients who received Hyperbaric Bupivacaine 0.5% 10 mg and dexmedetomidine 10 μg (G1), and 28 patients who received an institutional standard treatment with Hyperbaric Bupivacaine 0.5% 10 mg and sufentanil 5 μg (G2). We evaluated the difference in terms of motor and sensory block, postoperative pain, and adverse effects during the first 24 h following delivery and neonatal outcome. Our study found that the sufentanil group had a significantly lower requirement for analgesia than the dexmedetomidine group. Postoperative pain, assessed with the VAS scale, was stronger in G1 than in G2 (4 ± 2 vs. 2 ± 1, p-value < 0.01). Differences between the two groups regarding the intraoperative degree of motor and sensory block, motor recovery time, and neonatal Apgar scores were not noticed. Pruritus and shivering were observed only in G2. Itching and shivering did not occur in the dexmedetomidine group. Postoperative analgesia was superior in the sufentanil group, but the incidence of side effects was higher. Adjuvant dexmedetomidine prevented postoperative shivering.

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Section: Introductionmentioning

confidence: 99%

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Coviello

Iacovazzo

D’Abrunzo

et al. 2022

JCM

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Pharmacodynamics of intrathecal and epidural fadolmidine, an α2-adrenoceptor agonist, after bolus and infusion in dogs—comparison with clonidine

Leino

Yaksh

Horais

et al. 2020

Naunyn-Schmiedeberg's Arch Pharmacol

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Terminal cancer pain intractable by conventional pain management can be effectively relieved by intrathecal administration of a local anaesthetic plus an opioid and an alfa₂-agonist into the cerebro-spinal-fluid

Breivik

2017

Scandinavian Journal of Pain

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30 μg de clonidine en intrathécal prolonge l'analgésie du travail, mais augmente l'incidence des hypotensions et des anomalies du rythme cardiaque fœtal

Cited by 6 publications

References 22 publications

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Pharmacodynamics of intrathecal and epidural fadolmidine, an α2-adrenoceptor agonist, after bolus and infusion in dogs—comparison with clonidine

Terminal cancer pain intractable by conventional pain management can be effectively relieved by intrathecal administration of a local anaesthetic plus an opioid and an alfa₂-agonist into the cerebro-spinal-fluid

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30 μg de clonidine en intrathécal prolonge l'analgésie du travail, mais augmente l'incidence des hypotensions et des anomalies du rythme cardiaque fœtal

Cited by 6 publications

References 22 publications

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Sufentanil vs. Dexmedetomidine as Neuraxial Adjuvants in Cesarean Section: A Mono-Centric Retrospective Comparative Study

Pharmacodynamics of intrathecal and epidural fadolmidine, an α2-adrenoceptor agonist, after bolus and infusion in dogs—comparison with clonidine

Terminal cancer pain intractable by conventional pain management can be effectively relieved by intrathecal administration of a local anaesthetic plus an opioid and an alfa2-agonist into the cerebro-spinal-fluid

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Product

Resources

About

Terminal cancer pain intractable by conventional pain management can be effectively relieved by intrathecal administration of a local anaesthetic plus an opioid and an alfa₂-agonist into the cerebro-spinal-fluid