30 years on from the molecular cloning of interferon-tau

Roberts, R. Michael

doi:10.1530/rep-17-0585

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…In cattle, endometrial gene expression between cyclic and pregnant animals did not differ until pregnant days 15-17 (Walker et al 2010, Forde et al 2011, Bauersachs et al 2012, but transcriptomic differences between cyclic and pregnant animals become apparent at the time of pregnancy recognition. Interferon tau (IFNT) is the major factor essential for the process of maternal recognition of pregnancy (Bazer & Thatcher 2017, Ealy & Wooldridge 2017, Forde & Lonergan 2017, Roberts 2017. It has been reported that sufficient concentrations of IFNT must be released by the elongating conceptus between pregnant days 15 and 17 (P15 and P17, respectively), inducing the expression of a large number of interferon-stimulated genes in the endometrium, which leads to the establishment of uterine receptivity to conceptus implantation in ruminant ungulates (Spencer et al 2013, Wiltbank et al 2016.…”

Section: Introductionmentioning

confidence: 99%

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

Nakamura

Kusama

Ideta³

et al. 2020

Reproduction

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Extracellular vesicles (EVs) present in uterine lumen are involved in conceptus-endometrial interactions during the pre-implantation period. Despite numerous studies conducted on interferon tau (IFNT), a major protein of maternal recognition of pregnancy, the effect of intrauterine EVs on the endometrium during pre-implantation periods has not been well-characterized. To characterize conceptus-derived intrauterine EVs independent of IFNT, transcripts found from RNA-seq analysis in RNAs extracted from primary bovine endometrial epithelial cells (EECs) treated with cyclic day 17 (C17) EVs, pregnant day 17 (P17) EVs or IFNT were analyzed. These analyses identified 82 transcripts uniquely induced by IFNT-independent P17 EVs, of which a large number of transcripts were associated with ‘the TNF signaling pathway’ and ‘Inflammatory response’. Moreover, high expression of CD40L, a member of the TNF superfamily, and its receptor CD40 were found in P17 EVs and in EECs, respectively. Furthermore, the expression of TNF signaling pathway-related genes was up-regulated by the treatment with P17 EVs, but these increases were down-regulated by NF-kB signaling inhibitor. These findings suggest that P17 EVs could induce a pro-inflammatory response in the endometrium, independent of IFNT, to regulate uterine receptivity, facilitating conceptus implantation.

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Section: Introductionmentioning

confidence: 99%

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

Nakamura

Kusama

Ideta³

et al. 2020

Reproduction

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“…During the preimplantation period, the hatched bovine blastocyst undergoes significant morphological changes, passing sequentially from a spherical-to ovoid-, then tubular-and finally filamentous-shaped structure that primarily involves proliferation of the conceptus trophectoderm cells. During this time, the elongating conceptus secretes interferon tau (IFNT), the maternal pregnancy recognition signal in ruminants [4,5]. In contrast to pre-hatching development, elongation is predominantly maternally driven, dependent on substances in the uterine lumen fluid (or histotroph) [6]; blastocysts do not elongate in vitro [7] and the absence of uterine glands in vivo results in failure of blastocysts to elongate following embryo transfer [8].…”

Section: Introductionmentioning

confidence: 99%

Bovine endometrium responds differentially to age-matched short and long conceptuses†

Sánchez

Mathew

Behura

et al. 2019

Biology of Reproduction

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This study combined in vitro production of bovine blastocysts, multiple embryo transfer techniques, and a conceptus-endometrial explant co-culture system to test the hypothesis that bovine endometrium exposed to long vs. short day 15 conceptuses would exhibit a different transcriptome profile reflective of potential for successful pregnancy establishment. Bovine endometrial explants collected at the late luteal stage of the estrous cycle were cultured in RPMI medium for 6 h with nothing (control), 100 ng/mL recombinant ovine interferon tau (IFNT), a long day 15 conceptus, or a short day 15 conceptus. Transcriptional profiling of the endometrial explants found that exposure of endometrium to IFNT, long conceptuses, or short conceptuses altered (P < 0.05) expression of 491, 498, and 230 transcripts, respectively, compared to the control. Further analysis revealed three categories of differentially expressed genes (DEG): (i) commonly responsive to exposure to IFNT and conceptuses, irrespective of size (n = 223); (ii) commonly responsive to IFNT and long conceptuses only (n = 168); and genes induced by the presence of a conceptus but independent of IFNT (n = 108). Of those 108 genes, 101 were exclusively induced by long conceptuses and functional analysis revealed that regulation of molecular function, magnesium-ion transmembrane transport, and clathrin coat assembly were the principal gene ontologies associated with these DEG. In conclusion, bovine endometrium responds differently to age-matched conceptuses of varying size in both an IFNT-dependent and -independent manner, which may be reflective of the likelihood of successful pregnancy establishment.

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“…As a lineage evolves from multiples to singletons, mutations that target either manner of sustaining the corpus luteum can generate gestational drivers, and novel drivers could end up becoming what appear to be novel signals of early pregnancy. In ruminants, the signal of early pregnancy is interferon-τ, which is unique to their lineage and is encoded by the IFNT gene, a tandem duplicate of the gene for IFN-ω (IFNW) [ 29 , 30 ]. IFN-τ serves an anti-luteolytic function by blocking the action of prostaglandin F2α, which itself causes regression of the corpus luteum.…”

Section: Predictions Of the Gestational Drive Hypothesismentioning

confidence: 99%

Selfish evolution of placental hormones

Keegan

Patten

2022

Evolution, Medicine, and Public Health

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We hypothesize that some placental hormones—specifically those that arise by tandem duplication of genes for maternal hormones—may behave as gestational drivers, selfish genetic elements that encourage the spontaneous abortion of offspring that fail to inherit them. Such drivers are quite simple to evolve, requiring just three things: a decrease in expression or activity of some essential maternal hormone during pregnancy; a compensatory increase in expression or activity of the homologous hormone by the placenta; and genetic linkage between the two effects. Gestational drive may therefore be a common selection pressure experienced by any of the various hormones of mammalian pregnancy that have arisen by tandem gene duplication. We examine the evolution of chorionic gonadotropin in the human lineage in light of this hypothesis. Finally, we postulate that some of the difficulties of human pregnancy may be a consequence of the action of selfish genes.

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30 years on from the molecular cloning of interferon-tau

Cited by 9 publications

References 8 publications

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle

Bovine endometrium responds differentially to age-matched short and long conceptuses†

Selfish evolution of placental hormones

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