30 Years of Study of
 Kingella Kingae
 :
 Post Tenebras
 ,
 Lux

Ceroni, Dimitri; Dubois-Ferrière, Victor; Cherkaoui, Abdessalam; Lamah, Léopold; Renzi, Gesuèle; Lascombes, P.; Belaieff, Wilson; Schrenzel, Jacques

doi:10.2217/fmb.12.144

Cited by 27 publications

(35 citation statements)

References 102 publications

(212 reference statements)

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“…The list of genomes that contain HKIII genes is enriched with plant, animal, and human pathogens, providing additional support for a hypothesis that these signal transduction systems control TFP-mediated motility, a well-known virulence factor (41)(42)(43)(44)(45)(46). Many of the species that contain HKIIIs are associated with infections in cystic fibrosis and immunocompromised patients, including Burkholderia cepacia (47), B. cenocepacia (48), B. contaminans (49), B. gladioli (50), B. multivorans (50,51), B. vietnamiensis (50), Pandoraea apista (50), P. pulmonicola (50), P. sputorum (52), and Ralstonia pickettii (50), among others.…”

Section: Class III Histidine Kinasesmentioning

confidence: 91%

Class III Histidine Kinases: a Recently Accessorized Kinase Domain in Putative Modulators of Type IV Pilus-Based Motility

et al. 2017

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Histidine kinases are key components of regulatory systems that enable bacteria to respond to environmental changes. Two major classes of histidine kinases are recognized on the basis of their modular design: classical (HKI) and chemotaxis specific (HKII). Recently, a new type of histidine kinase that appeared to have features of both HKIs and HKIIs was identified and termed HKIII; however, the details of HKIII's relationship to other two classes of histidine kinases, their function, and evolutionary history remain unknown. Here, we carried out genomic, phylogenetic, and protein sequence analyses that allowed us to reveal the unusual evolutionary history of this protein family, formalize its distinctive features, and propose its putative function. HKIIIs are characterized by the presence of sensory domains and the lack of a dimerization domain, which is typically present in all histidine kinases. In addition to a single-domain response regulator, HKIII signal transduction systems utilize CheX phosphatase and, in many instances, an unorthodox soluble chemoreceptor that are usual components of chemotaxis signal transduction systems. However, many HKIII genes are found in genomes completely lacking chemotaxis genes, thus decoupling their function from chemotaxis. By contrast, all HKIIIcontaining genomes also contain pilT, a marker gene for bacterial type IV pilus-based motility, whose regulation is proposed as a putative function for HKIII. These signal transduction systems have a narrow phyletic distribution but are present in many emerging and opportunistic pathogens, thus offering an attractive potential target for future antimicrobial drug design.IMPORTANCE Bacteria adapt to their environment and their hosts by detecting signals and regulating their cellular functions accordingly. Here, we describe a largely unexplored family of signal transduction histidine kinases, called HKIII, that have a unique modular design. While they are currently identified in a relatively short list of bacterial species, this list contains many emerging pathogens. We show that HKIIIs likely control bacterial motility across solid surfaces, which is a key virulence factor in many bacteria, including those causing severe infections. Full understanding of this putative function may help in designing effective drugs against pathogens that will not affect the majority of the beneficial human microbiome.KEYWORDS chemotaxis, evolution, genomics, histidine kinase, motility, pathogens, signal transduction, type IV pili T he transmission of molecular signals in prokaryotes is carried out by the specialized cellular machinery. The simplest signal transduction systems consist of a single protein that is capable of both sensing a signal and directly affecting a cellular

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Section: Class III Histidine Kinasesmentioning

confidence: 91%

Class III Histidine Kinases: a Recently Accessorized Kinase Domain in Putative Modulators of Type IV Pilus-Based Motility

et al. 2017

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“…[1][2][3] We report a boy with extensive fasciitis of both lower limbs and pelvis detected by magnetic resonance imaging in a setting of K. kingae infective endocarditis and femoral osteomyelitis. We found no similar cases in the literature.…”

Section: Fasciitis In a Boy With Kingella Kingae Infective Endocarditismentioning

confidence: 99%

“…3 It is associated with bacteraemia, musculoskeletal infections in children aged 6 months to 4 years and is a rare cause of endocarditis and meningitis. [1][2][3] Endocarditis is the most severe manifestation of K. kingae infection. Reports of soft tissue infections due to K. kingae are rare in the medical literature.…”

Section: Fasciitis In a Boy With Kingella Kingae Infective Endocarditismentioning

confidence: 99%

“…[1][2][3] It is included in the HACEK group of organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens and Kingella species) that are collectively responsible for up to 5% of cases of bacterial endocarditis. 3 It is associated with bacteraemia, musculoskeletal infections in children aged 6 months to 4 years and is a rare cause of endocarditis and meningitis. [1][2][3] Endocarditis is the most severe manifestation of K. kingae infection.…”

Section: Dear Editor Fasciitis In a Boy With Kingella Kingae Infectimentioning

confidence: 99%

“…Reports of soft tissue infections due to K. kingae are rare in the medical literature. 1,3 Fasciitis is inflammation of the fascia surrounding muscles, blood vessels and nerves. Necrotising fasciitis is rare in children but is associated with a high morbidity and mortality, even with prompt medical and surgical intervention.…”

Section: Dear Editor Fasciitis In a Boy With Kingella Kingae Infectimentioning

confidence: 99%

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Fasciitis in a Boy with Kingella Kingae Infective Endocarditis

Yazidi

Hameed

Isaacs

et al. 2018

J Paediatrics Child Health

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Dear Editor, FASCIITIS IN A BOY WITH KINGELLA KINGAE INFECTIVE ENDOCARDITISKingella kingae is a known cause of infective endocarditis. [1][2][3] We report a boy with extensive fasciitis of both lower limbs and pelvis detected by magnetic resonance imaging in a setting of K. kingae infective endocarditis and femoral osteomyelitis. We found no similar cases in the literature. In October 2015, a previously healthy 16-month-old boy was admitted to The Children's Hospital at Westmead with clinical signs of right-sided distal femoral osteomyelitis. He presented with a 2-week history of refusal to walk and daily fevers of 39 C. He had a pansystolic murmur in the mitral area and shortness of breath. Magnetic resonance imaging of the lower limbs demonstrated enhancement of the right proximal tibia and the distal right femoral epiphysis, suggestive of early osteomyelitis. It also showed extensive subcutaneous and fascial oedema involving the pelvis and lower legs bilaterally, without a discrete collection suggestive of fasciitis in T1-weighted sequence (Fig. 1). Clinically, the boy had no signs or symptoms suggestive of necrotising fasciitis like erythema, swelling or extreme pain in his lower limbs. We cultured K. kingae sensitive to penicillin from his blood once; this result and his pansystolic murmur prompted investigations for infective endocarditis. The echocardiogram revealed a large mitral valve vegetation, and he underwent surgical removal of the vegetation together with a mitral valve repair. He was treated with 4 weeks of intravenous ceftriaxone and was well at 1-year follow-up.Kingella kingae is a Gram-negative coccobacillus that commonly colonises the oropharynx of young children and is readily transmitted from person to person. [1][2][3] It is included in the HACEK group of organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens and Kingella species) that are collectively responsible for up to 5% of cases of bacterial endocarditis. 3 It is associated with bacteraemia, musculoskeletal infections in children aged 6 months to 4 years and is a rare cause of endocarditis and meningitis. [1][2][3] Endocarditis is the most severe manifestation of K. kingae infection. Reports of soft tissue infections due to K. kingae are rare in the medical literature. 1,3 Fasciitis is inflammation of the fascia surrounding muscles, blood vessels and nerves. Necrotising fasciitis is rare in children but is associated with a high morbidity and mortality, even with prompt medical and surgical intervention. Staphylococcus aureus and Streptococcus pyogenes are the most common causes of infective fasciitis. 4 Our patient did not have clinical findings suggestive of infective fasciitis but the fascial oedema is most likely related to the invasive K. kingae infection in the absence of other possible causes. Extensive fasciitis in children with K. kingae endocarditis has not been reported in the literature before.

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Septic Sequelae in the Pediatric Shoulder Girdle

Steiger

Ceroni

2022

Congenital and Acquired Deformities of the Pediatric Shoulder Girdle

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30 Years of Study of Kingella Kingae : Post Tenebras , Lux

Cited by 27 publications

References 102 publications

Class III Histidine Kinases: a Recently Accessorized Kinase Domain in Putative Modulators of Type IV Pilus-Based Motility

Class III Histidine Kinases: a Recently Accessorized Kinase Domain in Putative Modulators of Type IV Pilus-Based Motility

Fasciitis in a Boy with Kingella Kingae Infective Endocarditis

Septic Sequelae in the Pediatric Shoulder Girdle

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