30 Hz Theta-burst Stimulation Over Primary Somatosensory Cortex Modulates Corticospinal Output to the Hand

Jacobs, Mark F.; Tsang, Philemon; Lee, Kevin G.H.; Asmussen, Michael J.; Zapallow, Christopher M.; Nelson, Aimee J.

doi:10.1016/j.brs.2013.12.009

Cited by 33 publications

(30 citation statements)

References 54 publications

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“…[94] Different findings were observed in modulating ICF with TBS, where ICF remained unchanged with cTBS, [87,95] or showed decrease in ICF. [65,96] There was no effect in modulation of ICF with iTBS. [65,87] These varied results may be due to the opposite current direction used in two studies as responses in these paradigms are dependent on stimulation parameters.…”

Section: Motor Versus Nonmotormentioning

confidence: 91%

“…One reason could be that the TBS effects on SICI are highly intensity dependent . Different findings were observed in modulating ICF with TBS, where ICF remained unchanged with cTBS, or showed decrease in ICF . There was no effect in modulation of ICF with iTBS .…”

Section: Motor Versus Nonmotormentioning

confidence: 92%

“…Remote suppression of M1 excitability can be caused by cTBS on premotor cortex, [102] and when cTBS was applied to the primary somatosensory cortex, an increase in MEPs was seen with no change in SICI or ICF on M1 circuitry. [96] In addition, the evidence of cerebellar efferent modulation to the motor cortex was observed when the induction of cTBS over lateral cerebellum caused a reduction in SICI within the contralateral M1. [103] However, evaluation of TBS effects in other brain regions, such as parietal cortex and PFC, requires different approaches.…”

Section: Motor Versus Nonmotormentioning

confidence: 99%

“…TBS influences on the modulation of corticocortical and intracortical circuits have been demonstrated in other brain regions with respect to M1. Remote suppression of M1 excitability can be caused by cTBS on premotor cortex, and when cTBS was applied to the primary somatosensory cortex, an increase in MEPs was seen with no change in SICI or ICF on M1 circuitry . In addition, the evidence of cerebellar efferent modulation to the motor cortex was observed when the induction of cTBS over lateral cerebellum caused a reduction in SICI within the contralateral M1 …”

Section: Motor Versus Nonmotormentioning

confidence: 99%

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Theta-Burst Stimulation: A New Form of TMS Treatment for Depression?

2014

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Major depressive disorder (MDD) is a common debilitating condition where only one third of patients achieve remission after the first antidepressant treatment. Inadequate efficacy and adverse effects of current treatment strategies call for more effective and tolerable treatment options. Transcranial magnetic stimulation (TMS) is a noninvasive approach to manipulate brain activity and alter cortical excitability. There has been more than 15 years of research on the use of repetitive form of TMS (rTMS) for the treatment of patients with depression, which has shown it to be an effective antidepressant treatment. Even though rTMS treatment has shown efficacy in treating depression, there is a high degree of interindividual variability in response. A newer form of rTMS protocol, known as theta-burst stimulation (TBS), has been shown to produce similar if not greater effects on brain activity than standard rTMS. TBS protocols have a major advantage over standard rTMS approaches in their reduced administration duration. Conventional rTMS procedures last between 20 and 45 min, as compared to TBS paradigms that require 1 to 3 min of stimulation. Recently, a small number of studies have suggested that TBS has similar or better efficacy in treating depression compared to rTMS. Optimization, identification of response predictors, and clarification of neurobiological mechanisms of TBS is required if it is to be further developed as a less time intensive, safe, and effective treatment for MDD.

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Section: Motor Versus Nonmotormentioning

confidence: 91%

Section: Motor Versus Nonmotormentioning

confidence: 92%

Section: Motor Versus Nonmotormentioning

confidence: 99%

Section: Motor Versus Nonmotormentioning

confidence: 99%

See 2 more Smart Citations

Theta-Burst Stimulation: A New Form of TMS Treatment for Depression?

2014

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“…This strategy may be even superior in the case of extensive damage to motor pathways. In healthy individuals, repetitive TMS and tDCS of PM and of SI can indeed increase the excitability of the ipsilateral MI (Boros, Poreisz, Münchau, Paulus, & Nitsche, 2008; Jacobs et al, 2014; Rizzo et al, 2004). Cortico-cortical paired TMS stimuli to PPC and MI potentiate ipsilateral corticospinal excitability (Koch et al, 2007), facilitate neuroplasticity in MI and modulate PPC-MI connectivity (Chao et al, 2015), as compared with unconditioned MI stimulation.…”

Section: Sensory-based Strategies To Enhance Post-stroke Motor Recmentioning

confidence: 98%

The sensory side of post-stroke motor rehabilitation

Bolognini

Russo

Edwards

2016

RNN

142

136

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Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therapy and reintegration is implied, but seldom targeted. However, the planning and execution of voluntary movement requires that the brain extracts sensory information regarding body position and predicts future positions, by integrating a variety of sensory inputs with ongoing and planned motor activity. Neurological patients who have lost one or more of their senses may show profoundly affected motor functions, even if muscle strength remains unaffected. Following stroke, motor recovery can be dictated by the degree of sensory disruption. Consequently, a thorough account of sensory function might be both prognostic and prescriptive in neurorehabilitation. This review outlines the key sensory components of human voluntary movement, describes how sensory disruption can influence prognosis and expected outcomes in stroke patients, reports on current sensory-based approaches in post-stroke motor rehabilitation, and makes recommendations for optimizing rehabilitation programs based on sensory stimulation.

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Neuroplasticity Protocols

Pedapati

2016

Pediatric Brain Stimulation

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30 Hz Theta-burst Stimulation Over Primary Somatosensory Cortex Modulates Corticospinal Output to the Hand

Cited by 33 publications

References 54 publications

Theta-Burst Stimulation: A New Form of TMS Treatment for Depression?

Theta-Burst Stimulation: A New Form of TMS Treatment for Depression?

The sensory side of post-stroke motor rehabilitation

Neuroplasticity Protocols

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